Overall and peripheral lung function assessment by spirometry and forced oscillation technique in relation to asthma diagnosis and control

Abstract

Resistance FOT measures were equally informative as spirometry, related to asthma diagnosis, and, furthermore, offered additive information to FEV /FVC, supporting a complementary role for FOT. Asthma control was related to FOT measures of peripheral airways, suggesting a potential use in identifying such involvement. Further studies are needed to determine a clinical value and relevant reference values in children, for the multifrequency FOT measurements.

Small airway function in children with mild to moderate asthmatic symptoms

“…Studies on the association between small airway dysfunction and asthma control questionnaires are conflicting and mainly restricted to adults. 4,26,40 We found no association between the investigated lung function indexes and C-ACT scores. However, only 22% of the study participants reported an uncontrolled disease on the C-ACT, which complicates segregation based on the questionnaire.…”

“…In accordance with our findings, the postulated small airway IOS indexes have been found to correlate with midexpiratory flow spirometric parameters, 41 whereas CALV seems unrelated to IOS and spirometry. 40 However, CALV has been found to correlate with Scond and Sacin in children with asthma. 34 We found an association between CALV and Scond but not with Sacin.…”

Identifying pediatric lung disease: A comparison of forced oscillation technique outcomes

“…Similarly, the impact of salmeterol on baseline lung function can not be excluded despite being withheld on the day of measurement. However, Fres has been shown to be altered in both controlled and uncontrolled asthma, with differences from healthy controls greater in uncontrolled asthma . Finally, although we only examined the ability of FOT outcomes to identify asthma from healthy controls, others have suggested that Fres may be able to predict a 10% change in FEV1, further supporting the suggestion of Fres displaying strong clinical relevance in young children with asthma.…”

Application of the Forced Oscillation Technique in Diagnosing and Monitoring of Asthma in Preschool Children

“…In the Heijkenskjöld et al [28] study, resistance assessment by FOT was not only equal to spirometry in the evaluation of patients with asthma but also, together with the assessment of reactance, provided additional information on the condition of peripheral airways, the state of which correlated with the degree of asthma control.…”

“…Therefore, in the absence of control of asthma symptoms, it is important to assess the peripheral airways [42], which is possible by means of the FOT. FOT proved to be a complementary method to spirometry providing additional information about peripheral airways [28] and has been suggested to be more sensitive in detecting airway obstruction because of no "deep inspiration" effect on bronchial tone required with a forced manoeuvre [30].…”