Overactivation of the Endocannabinoid System in Adolescence Disrupts Adult Adipose Organ Function in Mice
Kwang-Mook Jung,
Lin Lin,
Daniele Piomelli
Abstract:Cannabis use stimulates calorie intake, but epidemiological studies show that people who regularly use it are leaner than those who don’t. Two explanations have been proposed for this paradoxical finding. One posits that Δ9-tetrahydrocannabinol (THC) in cannabis desensitizes adipose CB1 cannabinoid receptors, stopping their stimulating effects on lipogenesis and adipogenesis. Another explanation is that THC exposure in adolescence, when habitual cannabis use typically starts, produces lasting changes in the de… Show more
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