2002
DOI: 10.1016/s0923-1811(01)00171-2
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Overactivation of IL-4-induced activator protein-1 in atopic dermatitis

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Cited by 20 publications
(19 citation statements)
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“…We have previously shown that AP-1 is a prominent transcription factor in T cells in response to IL-4 [4, 20]. Therefore, we next checked modulations of AP-1 activation by rolipram.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…We have previously shown that AP-1 is a prominent transcription factor in T cells in response to IL-4 [4, 20]. Therefore, we next checked modulations of AP-1 activation by rolipram.…”
Section: Resultsmentioning
confidence: 99%
“…Th2-derived IL-4 is mandatory for the production of antigen-specific IgE from B cells, a best-known mediator in allergic disorders such as asthma or atopic dermatitis. Owing to the pivotal role of IL-4 in immediate allergies, we previously reported that in patients with atopic dermatitis T cell reactivity to IL-4 may play a pathogenic role [4]. In light of this view, mechanisms controlling the augmented IL-4 reactivity could be a target of pharmacological intervention.…”
Section: Introductionmentioning
confidence: 99%
“…IL-13 and IL-4 are known to induce isotype switching to IgE synthesis. IL-4 was detected immunohistochemically in several skin lesions of AD patients 55) , and that hyperreactivity plays a pathogenic role 56) . The mRNA expression of IL-4 was increased in DNCB group, whereas TJ treatment significantly suppressed IL-4 levels in DNCB-induced CD mice (Fig.…”
Section: ⅳ Discussionmentioning
confidence: 99%
“…IgE synthesis by B cells is regulated by Th2 cytokines, particularly IL-4 and IL-13. In humans, overproduction of IL-4 is a critical factor in AD development (22). Sensitization to an allergen reflects the allergen's ability to elicit a Th2 cell response, in which IL-4 and IL-13 drive IgE production by promoting class-switch recombination in B cells (17).…”
Section: A B C D Discussionmentioning
confidence: 99%