Over-the-Counter Supplements and Men's Health

El‐Khatib, Farouk M.; Yafi, Natalie R.; Yafi, Faysal A.

doi:10.1016/b978-0-12-816665-9.00015-9

Cited by 5 publications

(6 citation statements)

References 73 publications

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“…We found the genetic liability for two taxa, genus Oxalobacter and genus Fusicatenibacter , reached a statistical significance after FDR correction. Oxalobacter is one of the key taxa involved in the gut microbiome diversity of individuals [59], and previous studies showed that Oxalobacter formigenes plays an important role in oxalate absorption and secretion pathways in the gut [60]. Observational studies found controversial associations between the genus Oxalobacter and cognitive ability.…”

Section: Discussionmentioning

confidence: 99%

Mendelian Randomization analyses identify causal associations of human gut microbiome composition on intelligence

Yao,

Han,

Wang

et al. 2023

Preprint

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BackgroundGrowing evidence indicates that dynamic changes in the gut microbiome can affect intelligence; however, whether the relationships are causal is unknown.MethodsWe conducted a bidirectional two-sample Mendelian randomization (MR) analysis using the summary statistics from the largest GWAS meta-analysis of gut microbiota composition (n = 18,340) and intelligence (n = 269,867). Inverse-variance weighted method was used to conduct the MR analyses complemented by a range of sensitivity analyses to validate the robustness of the results. We further applied a two-step MR analysis to evaluate whether the effect of identified taxa on intelligence was mediated by regulating the brain volume.ResultsMR evidence suggested a risk effect of the genusOxalobacteron intelligence (β = -0.032; 95% confidence interval, -0.049 to -0.015;P= 1.88×10-4) and a protective effect of the genusFusicatenibacteron intelligence (β = 0.051; 95% confidence interval, 0.023 to 0.079;P= 3.03×10-4). In the other direction, we did not find causal evidence of intelligence on gut microbiome composition. The mediation analysis showed that the effect of genusFusicatenibacteron intelligence was partly mediated by regulating the brain volume, with a mediated proportion of 26.7% (95% confidence interval, 4.9% to 48.5%).ConclusionsOur findings may help reshape our understanding of the microbiota-gut-brain axis and development of novel intervention approaches for preventing cognitive impairment.

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Section: Discussionmentioning

confidence: 99%

Mendelian Randomization analyses identify causal associations of human gut microbiome composition on intelligence

Yao,

Han,

Wang

et al. 2023

Preprint

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“…Patients taking the anti-asthmatic medication without a doctor's prescription [refilling anti-asthmatic medications without physician visit] [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

Factors Associated with Suboptimal Control of Asthma among Adult Asthma Patients: A Cross-sectional Study

Lual¹,

Yizengaw²

2021

TORMJ

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Introduction: Asthma is a major public health problem that negatively impacts patients, families, and the community. Identifying risk factors for poor asthma control may greatly enhance the establishment of more effective treatment of asthma. The level of asthma control and risk factors for poor asthma control is relatively unknown in Ethiopia. Methods: A cross-sectional study was conducted on 150 adult asthma patients at the Outpatient Department (OPD) chest clinic of Jimma Medical Center (JMC), from February 15 –March 20, 2019. The Statistical Package for Social Science (SPSS) 21.0 was used for data analysis. Multivariate logistic regression was conducted to analyze the potential associated factors of suboptimal control of asthma. Results and Discussion: Of 150 adults diagnosed with asthma recruited in this study, 81 [54.0%] of them were females, and the mean age of the patients was 41.1 ± 12.4 years. Inhaled corticosteroid (ICS) plus short-acting beta-agonist (SABA) (64, 42.7%) was the most frequently used anti-asthmatic medication. Over one-fourth (26.0%) (95% CI, 19.2-33.8) of study participants had suboptimal asthma control. On multivariate logistic regression, being an urban dweller (AOR=3.70, p=0.025) and not applying proper inhalation technique (AOR=16.23, p=0.022) were increased the risk of suboptimal asthma control, while non-prescription anti-asthmatic drugs taking habit (AOR=0.25, p=0.010) reduces the odds of having suboptimal asthma control. Conclusion: Suboptimal asthma control is high among adult asthma patients. Being an urban dweller and not applying proper inhalation techniques were increased the likelihood of suboptimal asthma control, while non-prescription anti-asthmatic drugs taking habits had lower odds of suboptimal asthma control. The authors recommend large sample size studies on the comparative status of asthma control using prescription versus non-prescription anti-asthmatic medication.

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“…A standardized mixture of pollen of S. cereale (92%), Phleum pratense (timothy; 5%) and Zea mays (corn; 3%) branded as Graminex [ 106 ] has been studied by Locatelli et al [ 219 ], and carvacrol, a monoterpenoid, was identified as the predominant phenolic compound, followed by polyphenols quercetin, rutin, chlorogenic acid and gallic acid [ 219 ]. The microbiologically digested extract of the pollen mixture branded as Cernilton ® contains a large portion (40%) of S. cereale pollen, in addition to timothy (26%), maize (26%), pine (5%), orchard grass (2%), and alder (1%) pollen, as specified by one of the manufacturers [ 220 , 221 ]. Cernilton ® is a tablet formulation prepared from the cernitin pollen extract, which consists of water-soluble and acetone-soluble fractions, and is known to contain hydroxamic acid and β-sterols [ 220 , 222 ].…”

Section: Medicinal Plants Widely Used In the Treatment Of Bphmentioning

confidence: 99%

“…The microbiologically digested extract of the pollen mixture branded as Cernilton ® contains a large portion (40%) of S. cereale pollen, in addition to timothy (26%), maize (26%), pine (5%), orchard grass (2%), and alder (1%) pollen, as specified by one of the manufacturers [ 220 , 221 ]. Cernilton ® is a tablet formulation prepared from the cernitin pollen extract, which consists of water-soluble and acetone-soluble fractions, and is known to contain hydroxamic acid and β-sterols [ 220 , 222 ].…”

Section: Medicinal Plants Widely Used In the Treatment Of Bphmentioning

confidence: 99%

“…Based on early toxicologic and clinical studies, in 1994, Commission E approved the use of S. cereale , P. pratense, and Z. mays pollen extract for treatment of micturition difficulties associated with Alken stage I–II benign prostate enlargement [ 106 , 223 ]. Cernilton ® has been used to treat BPH for nearly 40 years [ 220 ]. The mechanism of action of rye grass pollen is not yet well known.…”

Section: Medicinal Plants Widely Used In the Treatment Of Bphmentioning

confidence: 99%

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Treatment of Benign Prostatic Hyperplasia by Natural Drugs

et al. 2021

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Benign prostatic hyperplasia (BPH) is one of the most common urinary diseases affecting men, generally after the age of 50. The prevalence of this multifactorial disease increases with age. With aging, the plasma level of testosterone decreases, as well as the testosterone/estrogen ratio, resulting in increased estrogen activity, which may facilitate the hyperplasia of the prostate cells. Another theory focuses on dihydrotestosterone (DHT) and the activity of the enzyme 5α-reductase, which converts testosterone to DHT. In older men, the activity of this enzyme increases, leading to a decreased testosterone/DHT ratio. DHT may promote prostate cell growth, resulting in hyperplasia. Some medicinal plants and their compounds act by modulating this enzyme, and have the above-mentioned targets. This review focuses on herbal drugs that are most widely used in the treatment of BPH, including pumpkin seed, willow herb, tomato, maritime pine bark, Pygeum africanum bark, rye pollen, saw palmetto fruit, and nettle root, highlighting the latest results of preclinical and clinical studies, as well as safety issues. In addition, the pharmaceutical care and other therapeutic options of BPH, including pharmacotherapy and surgical options, are discussed, summarizing and comparing the advantages and disadvantages of each therapy.

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Over-the-Counter Supplements and Men's Health

Cited by 5 publications

References 73 publications

Mendelian Randomization analyses identify causal associations of human gut microbiome composition on intelligence

Mendelian Randomization analyses identify causal associations of human gut microbiome composition on intelligence

Factors Associated with Suboptimal Control of Asthma among Adult Asthma Patients: A Cross-sectional Study

Treatment of Benign Prostatic Hyperplasia by Natural Drugs

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