Over-expression of protein tyrosine phosphatase 4A2 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma

Gao, Ying; Zhang, Mengping; Zheng, Zhaohui; Zhu, Yujia; Cheng, Qing; Rong, Jian; Weng, Hui-Wen; Xu, Yi; Miao, Yun; Zhang, Jiaxing

doi:10.18632/oncotarget.20550

Cited by 6 publications

(4 citation statements)

References 28 publications

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“…Similar observations were reported in esophageal squamous cell carcinoma . In nasopharyngeal cancer, high expression of both PRL‐2 and PRL‐3 was closely associated with poor survival outcome in patients.…”

Section: Prl Expression In Tumors and Metastases: Emerging Biomarker supporting

confidence: 85%

“…Also, in intrahepatic cholangiocarcinoma, which is the second most common liver malignant tumor type after the hepatocellular carcinoma, the expression of those two PRLs were associated with worse survival leading to a negative prognostic impact [104]. Similar observations were reported in esophageal squamous cell carcinoma [105][106][107] cancer, high expression of both PRL-2 [108] and PRL-3 [109] was closely associated with poor survival outcome in patients.…”

Section: Prl Expression In Tumors and Metastases: Emerging Biomarker supporting

confidence: 67%

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Physiological and oncogenic roles of the PRL phosphatases

et al. 2018

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The human Phosphatase of Regenerative Liver (PRL) family comprises three members (PRL-1, -2, -3; gene name PTP4A1, PTP4A2, PTP4A3) that are highly expressed in a majority of cancers. This review summarizes our current understanding of PRL biology, including an overview of their evolutionary relationships and the regulatory mechanisms controlling their expression. We provide an updated view on our current knowledge on the PRL functions in solid tumors, hematological cancer, and normal physiology, particularly emphasizing on the use of in vivo mouse models. We also highlight a novel relationship positioning PRL as a central node controlling magnesium homeostasis through an association with the CNNM proteins, which are involved in magnesium transport.

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Section: Prl Expression In Tumors and Metastases: Emerging Biomarker supporting

confidence: 85%

Section: Prl Expression In Tumors and Metastases: Emerging Biomarker supporting

confidence: 67%

Physiological and oncogenic roles of the PRL phosphatases

et al. 2018

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“…2). We also found that the gene expression of TMBIM6, AP2M1, and PTP4A2, which are correlated with cancer progression and the cell cycle [30][31][32] , was significantly increased by PPMP incubation in MDA-MB-231 human breast cancer cells, suggesting that PPMPs regulate the transcriptional activity of cancer cells.…”

Section: Ppmps Did Not Show Cytotoxicitymentioning

confidence: 62%

Polypropylene microplastics promote metastatic features in human breast cancer

Park

Hong

Kim

et al. 2023

Sci Rep

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Microplastics (MPs) are now a global issue due to increased plastic production and use. Recently, various studies have been performed in response to the human health risk assessment. However, these studies have focused on spherical MPs, which have smooth edges and a spherical shape and account for less than 1% of MPs in nature. Unfortunately, studies on fragment-type MPs are very limited and remain in the initial stages. In this study, we studied the effect that 16.4 µm fragment type polypropylene (PP) MPs, which have an irregular shape and sharp edges and form naturally in the environment, had on breast cancer. The detrimental effects of PPMPs on breast cancer metastasis were examined. Here, 1.6 mg/ml of PPMP, which does not induce cytotoxicity in MDA-MB-231, was used, and at this concentration, PPMP did not induce morphological changes or cellular migrating in the MDA-MB-231 and MCF-7 cells. However, PPMP incubation for 24 hours in the MDA-MB-231 cells significantly altered the level of cell cycle-related transcripts in an RNA-seq analysis. When confirmed by qRT-PCR, the gene expression of TMBIM6, AP2M1, and PTP4A2 was increased, while the transcript level of FTH1 was decreased. Further, secretion of the pro-inflammatory cytokine IL-6 from cancer cells was elevated with the incubation of PPMP for 12 hours. These results suggest that PPMP enhances metastasis-related gene expression and cytokines in breast cancer cells, exacerbating breast cancer metastasis.

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“…For example (28-30), CKS1, P27, and CENP-F have been found to be involved in the regulation of an abnormal cell cycle. Some oncoproteins and tumor suppressor genes, such as RAP2A, PTP4A2, and ECRG4 (31)(32)(33), are closely related to cell proliferation. Although many oncogenes and carcinogenic factors have been found to affect the occurrence and development of NPC, the exact mechanism is still unknown.…”

Section: Discussionmentioning

confidence: 99%

Potential Role of The Upregulation of The Zinc Finger Protein of The Cerebellum 2 In Nasopharyngeal Carcinoma

Peng

Li²,

Ding

et al. 2021

Preprint

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Background: Nasopharyngeal carcinoma (NPC) is a common type of cancer mainly caused by EB virus infection in southern China and Southeast Asia. Zinc finger protein of the cerebellum 2 has been reported to be dysregulated in numerous cancers. However, its role in NPC has not yet been completely investigated. Methods: ZIC2 mRNA expression and clinical role of NPC was explored by Gene Expression Omnibus (GEO) databases and tissue microarrays. Immunohistochemical (IHC) staining was used to assessed the protein expression level of ZIC2 in NPC. Moreover, functional enrichment analyses were performed by the overlapping genes of differentially expressed genes in NPC and ZIC2 related co-expressed genes. Cistrome Data Browser (Cistrome DB) and scatter diagrams displayed the possibility of ATAD2 as a target gene of ZIC2. Last, characteristic phenotype was identified by weighted gene co-expression network analysis (WGCNA).Results: The mRNA expression levels of ZIC2 were significantly increased in NPC within genechips and tissue microarrays (SMD = 2.14; 95% CI = 1.85–2.44). Increased ZIC2 correlated with poor prognosis in NPC patients. The IHC results also showed that ZIC2 protein expression in NPC tissues was remarkably higher than in control tissues. Enrichment analysis showed that genes positively related to ZIC2 are mainly enriched in cell division and in the cell cycle. WGCNA analysis discovered that NPC dataset GSE12452 may be positive correlated with N stage and nagetive correlated with grade. Conclusion: ZIC2 upregulation may promote NPC tumorigenesis through cancer cell proliferation and cell cycle regulation. ATAD2 may produce a marked effect as the downstream target of ZIC2.

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Over-expression of protein tyrosine phosphatase 4A2 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma

Cited by 6 publications

References 28 publications

Physiological and oncogenic roles of the PRL phosphatases

Physiological and oncogenic roles of the PRL phosphatases

Polypropylene microplastics promote metastatic features in human breast cancer

Potential Role of The Upregulation of The Zinc Finger Protein of The Cerebellum 2 In Nasopharyngeal Carcinoma

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