Over-expression of inositol 1,4,5-trisphosphate receptor type 3 in human endometrial cancer.

Abstract

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified inositol 1,4,5-trisphosphate receptor type 3, encoded by ITPR3, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. ITPR3 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of ITPR3 was correlated with overall survival in white patients with low mutational burden. ITPR3 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.