Over expression of HSP70 and HSF1 in endothelial cells during pre-eclamptic placental stress

Perumal, Ekambaram; Lavanya, S.

doi:10.1111/j.1479-828x.2010.01246.x

Cited by 9 publications

(5 citation statements)

References 33 publications

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“…The increased expression of HSF1 in endothelial cells from term PE suggests a possible protective role as stress specific natural adaptive response against the generated stress [75,76]. CRH, CYP11A1, TEAD3 showed an increased DNAm in preeclamptic placentas, suggesting a hormonal involvement in PE [25].…”

Section: Role Of Dna Methylation In the Pathophysiology Of Pementioning

confidence: 90%

Global DNA methylation in placental tissues from pregnant with preeclampsia: A systematic review and pathway analysis

et al. 2020

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Section: Role Of Dna Methylation In the Pathophysiology Of Pementioning

confidence: 90%

Global DNA methylation in placental tissues from pregnant with preeclampsia: A systematic review and pathway analysis

et al. 2020

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“…Hsp70 represents an antioxidative stress marker. The overexpression of Hsp70 and the heat shock transcription factor (Hsf1) seen in the pre-eclamptic endothelial cells suggests its possible protective role as stress-specific natural adaptive response against the generated stress30. As proposed by Molvarec et al 15, we hypothesise that haemodynamic stress, oxidative stress (placental or systemic), placental ischaemia, ischaemia of other organs as well as maternal systemic inflammatory response may contribute to the overexpression of Hsp70, resulting in elevated circulating Hsp70 levels.…”

Section: Discussionmentioning

confidence: 65%

Circulating heat shock protein mRNA profile in gestational hypertension, pre-eclampsia & foetal growth restriction

Hromadníková¹,

Dvořáková²,

Kotlabova³

et al. 2016

Indian J Med Res

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Background & objectives:Heat shock proteins (Hsp) are ubiquitously distributed phylogenetically conserved molecules that regulate cellular homeostasis and maintain the integrity and function of cellular proteins. Increased levels of Hsp in maternal circulation have been shown to be associated with increased risk of pregnancy related complications. The objective of this study was to explore extracellular Hsp mRNA levels in maternal circulation and quantified Hsp27, Hsp60, Hsp70, Hsp90 and Hsp70 binding protein 1 (HspBP1) mRNAs in maternal plasma samples using real-time reverse-transcriptase polymerase chain reaction.Methods:Pregnancies with gestational hypertension (GH) (n = 33), pre-eclampsia (PE) with or without foetal growth restriction (FGR) (n = 78) and FGR (n = 25) were involved in the study. Hsp gene expression was analysed in relation to the severity of the disease with respect to the degree of clinical signs, requirements for the delivery and Doppler ultrasound parameters.Results:Upregulation of Hsp70 was observed in patients with mild and severe PE (P = 0.004 and P = 0.005, respectively) and in pregnancies complicated with PE delivering before and after 34 wk of gestation regardless of the degree of clinical signs (P = 0.015 and P = 0.009, respectively). No difference in the expression of other Hsp genes among the studied groups was observed. No association between Hsp gene expression and Doppler ultrasonography parameters was found.Interpretation & conclusions:These data support that maternal circulation can reflect both maternal and foetal pathologic conditions. Hsp70 represents the sole plasmatic marker, and increased Hsp70 mRNA levels reflect maternal and placental stress response to pregnancy-related complications such as GH and PE, irrespective of the severity of the disease.

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“…Studies have demonstrated that oxidative stress is one of the key factor in complicating preeclampsia which results in preterm birth (Padmini et al 2009b;Padmini & Lavanya, 2011;Padmini & Lavanya, 2009a). The first line of defense for oxidative stress is not sufficient enough to combat with the generated stress.…”

Section: Discussionmentioning

confidence: 99%

“…HSP70 chaperones regulate important physiological processes such as cell cycle, cell differentiation and programmed cell death (Mayer & Bukau, 2005;Cobreros et al 2008). The over expression of HSP70 in relation to the oxidative stress generated in preeclamptic condition suggest their protective role in stress management prolonging the cell survival in the placental endothelial cells during preeclampsia (Padmini et al 2009b;Padmini & Lavanya, 2011).…”

Section: Introductionmentioning

confidence: 99%

Tea and Mint Extracts Modulate the HSP70 Expression in Preeclamptic Placental Explant

Padmini¹

2012

J. App. Pharm. Sci.

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Heat shock protein 70 is a molecular chaperone which expressed during oxidative stress to protect the cell from damage. Preeclampsia is a hypertensive disorder with an oxidative stress imbalance. Antioxidant defenses appear to be depleted during preeclampsia resulting in increased oxidative stress. Various alternative medicines are employed to increase the endogenous antioxidant level during preeclampsia. The aim of the present study was to determine the modulatory effect of medicinal plants, Camellia sinensis and Mentha spicata on oxidative stress, antioxidant and thiol status using placental explant as the model system. Placental explants were cultured from the placental tissues of both normotensive and preeclamptic subjects. The lipid peroxide, total antioxidant capacity, glutathione redox ratio, HSP70 levels were measured in the placental explants with and without incubation with tea, mint and mint-tea. The addition of these three extracts increased the TAC and GRR in both placental explants with decrease in the LPO level. The expression of HSP70 also decreased more significantly in preeclamptic explants on addition of tea and mint extracts due to the restoration of cell homeostasis via maintaining the antioxidant status. In view of the above results, mint-tea may emerge as an effective antioxidant, preventing cell damage during stress condition.

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Over expression of HSP70 and HSF1 in endothelial cells during pre-eclamptic placental stress

Abstract: The over expression of HSP70 and HSF1 seen in the pre-eclamptic endothelial cells suggests its possible protective role as stress specific natural adaptive response against the generated stress.

Cited by 9 publications

References 33 publications

Global DNA methylation in placental tissues from pregnant with preeclampsia: A systematic review and pathway analysis

Global DNA methylation in placental tissues from pregnant with preeclampsia: A systematic review and pathway analysis

Circulating heat shock protein mRNA profile in gestational hypertension, pre-eclampsia & foetal growth restriction

Tea and Mint Extracts Modulate the HSP70 Expression in Preeclamptic Placental Explant

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