Over‐diagnosis of hydatidiform mole in early tubal ectopic pregnancy

Burton, Julian; Lidbury, E. A.; Gillespie, Alan; Tidy, John; Smith, O. Watkins; Lawry, J; Hancock, Barry W.; Wells, Michael

doi:10.1046/j.1365-2559.2001.01151.x

Cited by 80 publications

(89 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hydatidiform moles are abnormal gestations characterised by the presence of hydropic changes affecting some or all of the placental villi associated with circumferential proliferation of trophoblast tissue [1]. They arise due to abnormal fertilisation.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Partial mole in ectopic pregnancy

Ghazi

Donovan

2006

Gynecol Surg

View full text Add to dashboard Cite

Objective: To evaluate the incidence of molar pregnancy in the fallopian tube pregnancy. Setting: Outpatient clinic. Patient: 32-year-old Asian woman. Intervention: Left salpingectomy. Outcome: Molar ectopic pregnancy. Result: Ectopic partial mole pregnancy. Conclusion: Molar pregnancy can occur in ectopic pregnancy. Clinically, molar pregnancy mimics normal tubal ectopic pregnancy.Keywords Tubal ectopic pregnancy . Molar pregnancy Case reportA 32-year-old Asian woman with four children was referred to the early pregnancy unit in January 2005. She was 11 weeks pregnant and was having vaginal bleeding that had started 7 days before admission and had included the passing of clots, which had settled. She had no associated pelvic or shoulder pain. Her past medical and surgical history was not significant. She was not a smoker and had no allergies.On examination her pulse was 88, blood pressure 120/68, and temperature 36.9ºC. High vaginal and chlamydia swabs were taken. The chest examination was clear, and the heart examination showed S1, S2. Abdominal examination showed tenderness over the left iliac fossa with no guarding or rigidity. The vulva was smeared with blood, and there was brown blood in the vagina. Internal examination revealed a bulky anteverted uterus with no adnexal masses. No tenderness over the pelvic area or cervical excitation could be identified.The pregnancy test in the hospital was positive. An ultrasound scan was arranged, which showed a bulky anteverted uterus with thin (4 mm) endometrium. No evidence of intrauterine pregnancy was seen, and both ovaries appeared normal. In the left adnexa there was a 44×25×38-mm complex mass. It appeared to be in the fallopian tube, and there was also a hydrosalpinx at the medial section. No free fluid was identified. The findings were consistent with ectopic pregnancy. The patient's beta human chorionic gonadotropin (BHCG) level on the day of admission was 12,894 U/l, and her haemoglobin level was 13 g/dl. She was RH-positive.A diagnosis of left tubal pregnancy was made, and the patient was prepared for surgery on the same day of admission. She was grouped and saved, and a diagnostic laparoscopy was done. Both ovaries and the right tube were normal, but a left tubal pregnancy could be seen actively bleeding in the tube. Laparotomy was performed, and the laparoscopic findings were confirmed. The left tube was found to be ruptured. A left salpingectomy was done and the specimen sent to histopathology. The patient recovered uneventfully and was discharged home on the 3rd day after admission. Her haemoglobin level on discharge was 10.3 g/dl. The swab results came back positive only for Candida, and the patient's general practitioner was informed.The histopathology report suggested partial hydatidiform mole of ectopic pregnancy (Fig. 1). Therefore, the patient was notified to be seen in the gynaecology clinic 6 weeks from the procedure for follow-up of the partial molar pregnancy. She was advised to refrain from getting pregnant until her HCG levels had been normal...

show abstract

Section: Resultsmentioning

confidence: 99%

“…They arise due to abnormal fertilisation. In a complete mole, the chromosomal component is 46XX, with a genome that is entirely paternal in origin [1,2]. This usually occurs when an empty ovum is fertilised by a haploid spermatozoon, which subsequently duplicates.…”

Section: Resultsmentioning

confidence: 99%

Partial mole in ectopic pregnancy

Ghazi

Donovan

2006

Gynecol Surg

View full text Add to dashboard Cite

show abstract

“…The chromosomal component is 46 XX while a partial mole occurs with fertilization of two sperms with a haploid ovum resulting in a triploid genome. [3][4][5][6] Molar pregnancy is seen in 1 in 500-1000 pregnancies. 7 Molar pregnancy at an ectopic site is a rare occurence.…”

Section: Discussionmentioning

confidence: 99%

Ectopic tubal pregnancy with partial mole: a rare case

Patil

Nazeer

Tele

2018

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Hydatidiform moles are abnormal gestations characterised by the presence of hydropic changes in the placental villi associated with circumferential trophoblastic proliferation. They arise due to abnormal fertilization. Molar gestation commonly develops within the uterus but presence of molar changes in ectopic pregnancy is extremely rare. Author present a rare case of ectopic molar pregnancy in fallopian tube in a 20 years old female patient to highlight its clinicopathological features. Ectopic molar pregnancy in a fallopian tube is very rare and histopathological study is the gold standard for the exact diagnosis and further management.

show abstract

“…Se encuentran en la literatura ciertos factores de riesgo asociados como lo son: la edad materna, edad gestacional al momento del diagnóstico, complicaciones posteriores a tratamiento quirúrgico, enfermedad pélvica inflamatoria, embarazo molar previo, nivel educativo, alta ingesta de vitamina A y tabaquismo. (1,2,3,4,5) Los síntomas presentes en estas pacientes son metrorragia (97%), náuseas, vómitos e hiperémesis (30%), preeclampsia (25%), expulsión de vesículas (11%) es patognomónico pero es un signo tardío y poco frecuente, hipertiroidismo (7%), insuficiencia respiratoria (2%), y desproporción del tamaño uterino con la edad gestacional (60%). (1) El embarazo molar lo podemos clasificar en dos tipos, parcial y completo que se diferencian según su presentación clínica, cariotipo, histología (edema de vellosidades, tejido fetal, hiperplasia), y desenlaces.…”

Section: Introductionunclassified