Ovariectomy influences the circadian rhythm of locomotor activity and the photic phase shifts in the volcano mouse

Juárez-Tapia, Cinthia; Miranda‐Anaya, Manuel

doi:10.1016/j.physbeh.2017.10.002

Cited by 12 publications

(3 citation statements)

References 74 publications

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“…Nevertheless, in line with an anxious phenotype, OVX also decreased locomotion, which was mainly detectable in controls. In support, volcano mice presented a scalloped pattern of daily activity during the estrous cycle and OVX reduced the total movement ( 115 ). Moreover, in estrogen receptor knockout mice (on C57BL6 background), E2 injection to OVX animals increased total activity and amplitude ( 116 ).…”

Section: Discussionmentioning

confidence: 95%

Ovariectomy-induced hormone deprivation aggravates Aβ1-42 deposition in the basolateral amygdala and cholinergic fiber loss in the cortex but not cognitive behavioral symptoms in a triple transgenic mouse model of Alzheimer’s disease

et al. 2022

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Alzheimer’s disease is the most common type of dementia, being highly prevalent in elderly women. The advanced progression may be due to decreased hormone synthesis during post-menopause as estradiol and progesterone both have neuroprotective potentials. We aimed to confirm that female hormone depletion aggravates the progression of dementia in a triple transgenic mouse model of Alzheimer’s disease (3xTg-AD). As pathological hallmarks are known to appear in 6-month-old animals, we expected to see disease-like changes in the 4-month-old 3xTg-AD mice only after hormone depletion. Three-month-old female 3xTg-AD mice were compared with their age-matched controls. As a menopause model, ovaries were removed (OVX or Sham surgery). After 1-month recovery, the body composition of the animals was measured by an MRI scan. The cognitive and anxiety parameters were evaluated by different behavioral tests, modeling different aspects (Y-maze, Morris water maze, open-field, social discrimination, elevated plus maze, light–dark box, fox odor, operant conditioning, and conditioned fear test). At the end of the experiment, uterus was collected, amyloid-β accumulation, and the cholinergic system in the brain was examined by immunohistochemistry. The uterus weight decreased, and the body weight increased significantly in the OVX animals. The MRI data showed that the body weight change can be due to fat accumulation. Moreover, OVX increased anxiety in control, but decreased in 3xTg-AD animals, the later genotype being more anxious by default based on the anxiety z-score. In general, 3xTg-AD mice moved less. In relation to cognition, neither the 3xTg-AD genotype nor OVX surgery impaired learning and memory in general. Despite no progression of dementia-like behavior after OVX, at the histological level, OVX aggravated the amyloid-β plaque deposition in the basolateral amygdala and induced early cholinergic neuronal fiber loss in the somatosensory cortex of the transgenic animals. We confirmed that OVX induced menopausal symptoms. Removal of the sexual steroids aggravated the appearance of AD-related alterations in the brain without significantly affecting the behavior. Thus, the OVX in young, 3-month-old 3xTg-AD mice might be a suitable model for testing the effect of new treatment options on structural changes; however, to reveal any beneficial effect on behavior, a later time point might be needed.

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Section: Discussionmentioning

confidence: 95%

Ovariectomy-induced hormone deprivation aggravates Aβ1-42 deposition in the basolateral amygdala and cholinergic fiber loss in the cortex but not cognitive behavioral symptoms in a triple transgenic mouse model of Alzheimer’s disease

et al. 2022

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“…40,41 Although this study did not directly assess circadian rhythms, others have reported on the importance of sex hormones in circadian rhythms and patterns. [42][43][44][45] The effect of sex hormone disruption on circadian rhythms, therefore, may be another factor to consider when developing individualized physical activity interventions in transgender individuals receiving treatment that disrupt sex hormone levels. It is possible that the ''typical'' approaches to promoting physical activity may not apply to individuals with possible circadian rhythm disruption.…”

Section: Discussionmentioning

confidence: 99%

Sex Hormone Suppression and Physical Activity: Possible Implications for Transgender Individuals

Hydock

2022

Transgender Health

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Transgender individuals tend to be less physically active than cisgender individuals, and the primary focus of these physical activity barriers have been psychosocial in nature. Very little attention has been given to the role that changes in the sex hormone milieu (such as that occurring during gender-affirming hormone therapy) play on physical activity. The purpose of this study was to explore the effects of sex hormone suppression using a gonadotropin-releasing hormone agonist (GnRHa) on physical activity levels and patterns. Methods: Female and male rats received 4 weeks of sex hormone suppression using the GnRHa goserelin acetate (GA) or received a placebo as a control (CON). Animals were then allowed free access to voluntary running wheels, and activity was recorded throughout the treatment period. Results: Female rats receiving GA (F GA) had a significantly lower total wheel running distance than female CON (F CON, 53 -11 km vs. 113 -28 km, respectively, p = 0.042), and male rats receiving GA (M GA) had a significantly lower total wheel running distance when compared with male CON (M CON, 31 -7 km vs. 69 -18 km, respectively, p = 0.037). Differences in daily wheel running distances were first observed at day 18 between F GA and F CON ( p = 0.037) and at day 2 between M GA and M CON ( p = 0.021). Conclusion: Reduced sex hormone availability reduced wheel running activity in female and male rats. Understanding the role that sex hormone manipulation has on physical activity may be an important consideration in promoting physical activity in transgender individuals receiving treatments that reduce sex hormone availability.

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“…Yet, the fitness consequences of hyperthermia may be greater in females, where the embryo cannot be thermally isolated and damage is irreversible (Greenwood and Wheeler, 1985). In consequence, the actions of sexspecific selection may lead to differences in traits that may not, initially, appear to be directly associated with sexual competitiveness, such as growth rate, thermoregulation, metabolic biorhythms, and environmental sensory (Glucksman, 1974;McPherson and Chenoweth, 2012;Juárez-Tapia and Miranda-Anaya, 2017;Calisi et al, 2018). Difference in lipid kinetics are hypothesized to maintain sexually dimorphic metabolic phenotypes (Mittendorfer, 2005).…”

Section: Metabolic Sexual Dimorphismmentioning

confidence: 99%

Disentangling environmental drivers of circadian metabolism in desert-adapted mice

Colella

Blumstein

MacManes

2020

Preprint

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Metabolism is a complex phenotype shaped by natural environmental rhythms, as well as behavioral, morphological, and physiological adaptations. Although historically studied under constant environmental conditions, continuous metabolic phenotyping through environmental transitions now offers a window into the physiological responses of organisms to changing environments. Here, we use flow-through respirometry to compare metabolic responses of the desert-adapted cactus mouse (Peromyscus eremicus) between diurnally variable and constant environmental conditions. We contrast metabolic responses to circadian cycles in photoperiod, temperature, and humidity, against those recorded under constant hot-and-dry and constant cold-and-wet conditions. We found significant sexual dimorphism in metabolic responses, despite no measurable difference in body weight. Males seem to be more heat tolerant and females more cold tolerant. Under circadian environmental cycling, the ratio of CO2 produced to O2 consumed (the respiratory quotient or respiratory exchange ratio) reached greater than one, a pattern that strongly suggests that lipogenesis is contributing to the production of energy and endogenous water in this species. This hypothesis is consistent with the results of previous dehydration experiments in this species, which documented significant weight loss in response to dehydration, without other physiological impairment. Our results are also consistent with historical descriptions of circadian torpor in this species (torpid by day, active by night), but reject the hypothesis that this pattern is driven by food restriction or negative water balance, as both resources were available to animals throughout the experiments.SUMMARY STATEMENTContinuous metabolic phenotyping of desert-adapted cactus mice (Peromyscus eremicus) identifies significant metabolic differences between the sexes and circadian patterning consistent with lipogenesis and environmental entrainment.

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Ovariectomy influences the circadian rhythm of locomotor activity and the photic phase shifts in the volcano mouse

Cited by 12 publications

References 74 publications

Ovariectomy-induced hormone deprivation aggravates Aβ1-42 deposition in the basolateral amygdala and cholinergic fiber loss in the cortex but not cognitive behavioral symptoms in a triple transgenic mouse model of Alzheimer’s disease

Ovariectomy-induced hormone deprivation aggravates Aβ1-42 deposition in the basolateral amygdala and cholinergic fiber loss in the cortex but not cognitive behavioral symptoms in a triple transgenic mouse model of Alzheimer’s disease

Sex Hormone Suppression and Physical Activity: Possible Implications for Transgender Individuals

Disentangling environmental drivers of circadian metabolism in desert-adapted mice

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