Ovariectomy hinders the early stage of bone-implant integration: histomorphometric, biomechanical, and molecular analyses

Ozawa, Shogo; Ogawa, Takahiro; Iida, Keisuke; Sukotjo, Cortino; Hasegawa, Hideki; Nishimura, Robert N.; Nishimura, Ichiro

doi:10.1016/s8756-3282(01)00646-9

Cited by 101 publications

(92 citation statements)

References 39 publications

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“…Postmenopausal osteoporosis is a skeletal disease characterized by reduced bone mass and deterioration of the bone micro-architecture, mainly due to increased bone resorption elicited by estrogen deficiency [3]. This medical condition is an important risk factor for implant failure in orthopedic and oral surgery, both during the healing as well as during the implant functional status [4][5][6]. Anti-resorption drugs, such as bisphosphonates, selective estrogen receptor modulators, and hormone therapy have been used to treat osteoporosis for years.…”

Section: Introductionmentioning

confidence: 99%

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

et al. 2014

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Summary High-frequency loading via whole body vibration promotes bone formation and increases bone strength. Whether this translates to positive titanium implant osseointegration in osteoporotic bone was explored in this animal study. An anabolic effect of not only bisphosphonate treatment but also high-frequency loading on implant osseointegration in osteoporotic bone was observed. Introduction The present study investigated the impact of high-frequency (HF) loading, applied via whole body vibration (WBV), on titanium implant osseointegration in healthy versus ovariectomyinduced compromised versus pharmacologically treated compromised bone. Methods A custom-made Ti implant was inserted into the metaphyseal tibia of 59 rats and left to heal for either 4 or 14 days. Rats were divided into six groups according to their hormonal and mechanical status. WBV, consisting of 10 consecutive frequency steps at an acceleration of 0.3g, was applied daily for either 4 or 14 days. Tissue samples were processed for quantitative histology at the tibial cortical and medullar level. Data were analyzed by three-way ANOVA and by post hoc pairwise comparisons. Results The bone healing response at the interface and surrounding titanium implants was negatively influenced by osteoporotic bone conditions, mainly at the trabecular bone level. Furthermore, the administration of bisphosphonates for preventing the ovariectomy-induced impaired periimplant response was successful. Finally, the effect of HF WBV loading on the peri-implant bone healing was dependent on the bone condition and was anabolic solely in untreated osteoporotic trabecular bone when applied for an extended period of time. ConclusionsThe bone healing response to implant installation is compromised in osteoporotic bone conditions, in particular at the trabecular bone compartment. Meanwhile, not only pharmacological treatment but also mechanical loading via HF WBV can exert a positive effect on implant osseointegration in this specific bone micro-environment. The peri-implant cortical bone, however, seems to be less sensitive to HF WBV loading influences.

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Section: Introductionmentioning

confidence: 99%

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

et al. 2014

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“…37,38 These changes have been observed in different animal studies by a decrease of trabecular bone volume as well as bone-to-implant contact around implants. 39,40 Bone regeneration techniques such sinus augmentation and autogenous onlay bone blocks have been reported to be a predictable treatment for the management of the atrophic maxilla, however, this anatomic challenge could be even more difficult in osteoporotic patients who need implant therapy.…”

Section: Discussionmentioning

confidence: 90%

Management of atrophic maxilla in severe osteoporosis treated with bisphosphonates: a case report

Torres

Tamimi

García

et al. 2008

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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“…Some studies have shown significant bone loss around these biomaterials, whereas others reported no difference in bone growth in the recipient areas of ovariectomized animals (Fini et al, 1997;Hayashi et al, 1994;Pan et al, 2000). This divergence might be due to the difficulty in standardizing methods for the correct quantification of bone tissue formed on the implant (Ozawa et al, 2002). In addition, few studies have characterized hydroxyapatite biomaterials introduced into bone defects created in ovariectomized rats in terms of the quantity and mechanical strength of the bone formed in the recipient area.…”

Section: Discussionmentioning

confidence: 99%

“…However, the authors cited above did not study any type of implant. However, Ozawa et al (2002) implanted titanium into bone defects created in the femur of ovariectomized rats. Biomechanical tests performed after 2 weeks showed that the mechanical strength in the recipient area of ovariectomized rats was half that found in nonovariectomized animals.…”

Section: Discussionmentioning

confidence: 99%

Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats

Ribeiro

Figueira

Issa

et al. 2011

Microscopy Res & Technique

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2012Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats MICROSCOPY RESEARCH AND TECHNIQUE, MALDEN, v. 75, n. 2, pp. 133-137, FEB, 2012 http://www.producao.usp.br/handle/BDPI/42523 ABSTRACT Osteoporosis is a global public health that affects postmenopausal women due to the deficiency of estrogen, a hormone that plays an important role in the microarchitecture of bone tissue. Osteoporosis predisposes to pathological bone fracture that can be repaired by conventional methods. However, depending on the severity and quantity of bone loss, the use of autogenous grafts or biomaterials such as hydroxyapatite might be necessary. The latter has received increasing attention in the medical field because of its good biological properties such as osteoconductivity and biocompatibility with bone tissue. The objective of this study was to evaluate using histologic and radiographic analyses, the osteogenic capacity of hydroxyapatite implanted into the femur of rats with ovariectomy-induced osteoporosis. Eighteen rats were divided into three groups with six animals in each: group nonovariectomized, bilaterally ovariectomized not receiving estrogen replacement therapy, and bilaterally ovariectomized submitted to estrogen replacement therapy. Defects were created experimentally in the distal epiphysis of the femur with a surgical drill and filled with porous hydroxyapatite granules. The animals were sacrificed 8 weeks after surgery. The volume of newly formed bone in the implant area was quantified by morphometrical methods. The results were analyzed by ANOVA followed by the Tukey test (P < 0.05). The hydroxyapatite granules showed good radiopacity. Histological analysis revealed less quantity of newly formed bone in the ovariectomized group not submitted to hormone replacement therapy. In conclusion, bone neoformation can be expected even in bones compromised by estrogen deficiency, but the quantity and velocity of bone formation are lower. Microsc. Res. Tech. 75:133-137, 2012. V

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Ovariectomy hinders the early stage of bone-implant integration: histomorphometric, biomechanical, and molecular analyses

Cited by 101 publications

References 39 publications

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

Management of atrophic maxilla in severe osteoporosis treated with bisphosphonates: a case report

Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats

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