Ovaric physiology in the first oestral cycle: Influence of noradrenergic and cholinergic neural stimuli from coeliac ganglion

Delgado, Silvia Marcela; Escudero, Consuelo; Casais, Marilina; Gordillo, Mauricio; Anzulovich, Ana Cecilia; Sosa, Zulema; Rastrilla, Ana María

doi:10.1016/j.steroids.2010.04.005

Cited by 19 publications

(11 citation statements)

References 64 publications

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“…These results suggest that the mechanisms regulating the synthesis of each hormone are not regulated by the same signals [36]. Using the ex vivo coeliac ganglion–superior ovarian nerve–ovary (CG–SON–O) model, Delgado et al [8] described that the expression of 3 beta - hydroxysteroid dehydrogenase (3-HSD) and P450 aromatase are modulated by noradrenergic or cholinergic vias.…”

Section: Discussionmentioning

confidence: 99%

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Effects on steroid hormones secretion resulting from the acute stimulation of sectioning the superior ovarian nerve to pre-pubertal rats

Morales‐Ledesma¹,

Vieyra²,

Ramírez³

et al. 2012

Reprod Biol Endocrinol

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In the adult rat, neural signals arriving to the ovary via the superior ovarian nerve (SON) modulate progesterone (P4), testosterone (T) and estradiol (E2) secretion. The aims of the present study were to analyze if the SON in the pre-pubertal rat also modulates ovarian hormone secretion and the release of follicle stimulating hormone (FSH) and luteinizing (LH) hormone. P4, T, E2, FSH and LH serum levels were measured 30 or 60 minutes after sectioning the SON of pre-pubertal female rats. Our results indicate that the effects on hormone levels resulting from unilaterally or bilaterally sectioning the SON depends on the analyzed hormone, and the time lapse between surgery and autopsy, and that the treatment yielded asymmetric results. The results also suggest that in the pre-pubertal rat the neural signals arriving to the ovaries via the SON regulate the enzymes participating in P4, T and E2 synthesis in a non-parallel way, indicating that the mechanisms regulating the synthesis of each hormone are not regulated by the same signals. Also, that the changes in the steroids hormones are not explained exclusively by the modifications in gonadotropins secretion. The observed differences in hormone levels between rats sacrificed 30 and 60 min after surgery reflect the onset of the compensatory systems regulating hormones secretion.

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Section: Discussionmentioning

confidence: 99%

“…The SON is one of the neural pathways involved in the control of ovarian functions, including puberty onset [3], ovulation [4-6] steroidogenesis, and compensatory ovarian hypertrophy [7,8]. …”

Section: Introductionmentioning

confidence: 99%

Effects on steroid hormones secretion resulting from the acute stimulation of sectioning the superior ovarian nerve to pre-pubertal rats

Morales‐Ledesma¹,

Vieyra²,

Ramírez³

et al. 2012

Reprod Biol Endocrinol

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“…ACh addition on D1 resulted in lower progesterone secretion, which was later followed by its increase. The secretion of androstenedione and estradiol also increased with cholinergic stimulation, while NO secretion decreased [91].…”

Section: Using Sophisticated In Vitro Methodologies Aguado's Groupmentioning

confidence: 86%

The Ovarian Innervation Participates in the Regulation of Ovarian Functions

Cruz-Morales¹

2012

Endocrinol Metabol Syndrome

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The release of gonadotropins is the main endocrine signal regulating ovulation and the release of hormones by the ovaries. Several types of growth factors modulate the effects of gonadotropins on the follicular, luteal and interstitial compartments of the ovaries. During the last 30 years, numerous studies have indicated that the ovarian innervations play a role in modulating the effects that gonadotropin have on the ovaries' ability to ovulate and secrete steroid hormones. This literature review presents a summary of the experimental results obtained by analyzing the effects of stimulating or blocking the well-known neural pathways participating in the regulation of ovulation and secretion of steroid hormones. Together, the results suggest that various neurotransmitter systems modulate the effects of gonadotropins on ovulation and the ovaries capacity to secrete steroid hormones. In addition, the ovaries asymmetric capacity for ovulation and hormone secretion could be explained by the asymmetries in their innervations.

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“…It has been reported that under physiological conditions, ACh acting by muscarinic receptor modulates the ovarian blood flow (Dynarowicz and Dzięgielewski 1987), the follicular development and steroidogenesis (Delgado et al 2010; Daneri et al 2013) as well as takes part in the ovulation (Walles et al 1976). In addition, NO (Masuda et al 2001; Barszczewska and Jaroszewski 2004), VIP (Miyamoto et al 1993; Hulshof et al 1994) and SOM (Panconesi et al 1987; Andreani et al 1995) may participate in the ovarian blood flow and/or steroidogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…Besides acetylcholine (ACh), these fibres synthesize and release also nitric oxide (NO), vasoactive intestinal peptide (VIP) and somatostatin (SOM; Majewski 1997). The involvement of ACh and the aforementioned substances in the regulation of ovarian function has been demonstrated (Trzeciak et al 1986; Dynarowicz and Dzięgielewski 1987; Masuda et al 2001; Barszczewska and Jaroszewski 2004; Nestorović et al 2008; Delgado et al 2010). …”

Section: Introductionmentioning

confidence: 99%

Changes in the Cholinergic Innervation Pattern of Porcine Ovaries with Cysts Induced by Dexamethasone Administration

2014

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We revealed earlier that induction of ovarian cysts in gilts by dexamethasone phosphate disodium salt (DXM) administration from the follicular phase of the estrous cycle (EC) changed the cholinergic innervation of the gonad. In the present study, the innervation of porcine ovaries by vesicular acetylcholine transporter (VAChT)-, neuronal nitric oxide synthase (nNOS)-, vasoactive intestinal peptide (VIP)- and somatostatin (SOM)-immunoreactive (IR) fibres, after induction of cystic changes from the middle luteal phase of the EC, was determined. The cystic changes were induced by DXM injections from days 7 to 21 of the EC, and 11 days later, the ovaries were collected. In the cystic ovaries, VAChT-, nNOS- and SOM-IR fibres were found around cysts and small tertiary follicles; nNOS-IR and also VAChT-IR fibres were observed near secondary follicles and veins; and VAChT- and nNOS-IR fibres were not found around cortical arteries. The number of VIP-IR fibres increased near the cysts and within the ground plexus, while the number of VAChT-IR fibres decreased within the medullar part of this structure. Thus, our study showed changes in the cholinergic innervation pattern of the porcine cystic ovaries induced from the middle phase of the cycle and confirmed that cystic ovary innervation depends partly on the phase of the EC in which the induction of cysts was started.

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Ovaric physiology in the first oestral cycle: Influence of noradrenergic and cholinergic neural stimuli from coeliac ganglion

Cited by 19 publications

References 64 publications

Effects on steroid hormones secretion resulting from the acute stimulation of sectioning the superior ovarian nerve to pre-pubertal rats

Effects on steroid hormones secretion resulting from the acute stimulation of sectioning the superior ovarian nerve to pre-pubertal rats

The Ovarian Innervation Participates in the Regulation of Ovarian Functions

Changes in the Cholinergic Innervation Pattern of Porcine Ovaries with Cysts Induced by Dexamethasone Administration

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