Ovarian yolk sac tumor

Iscar, Teresa; Areán, Carolina; Chiva, Luis; Sanz, Julian

doi:10.1136/ijgc-2021-002538

Cited by 3 publications

(1 citation statement)

References 2 publications

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“…Yolk sac tumour (YST) is the second most common ovarian germ cell tumour and usually occurs in infants and adolescents [1,2]. These tumours are typically found in the gonads and areas with a primitive extraembryonic morphology, but YSTs involving the endometrium and combined with epithelial ovarian carcinoma are extremely rare [3,4]. There are no guidelines for the treatment of malignant gynaecological tumours with YST components.…”

Section: Introductionmentioning

confidence: 99%

Cases of Yolk sac tumor associated with gynecological malignant tumor

Wang

Chen

et al. 2023

Preprint

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Background: Yolk sac tumour (YST) is the second most common ovarian germ cell tumour and usually presentsin children and young women. However, tumours rarely occur as malignant gynaecological tumourswith YST components. Case presentation: We present one case of endometrioid carcinoma and clear cell carcinoma with YST components and two other cases of YSTs associated with high-grade serous carcinoma of the ovary in females. After surgery and adjuvant chemotherapy, the patient withendometrioid carcinoma had progressive disease and died 20 months later,and the other two were still alive at thelast follow-up. Conclusions: To our knowledge, these mixed neoplasm associations areunusual,and these cases illustrate the diagnosis and prognosis of YST associated with malignant gynaecological tumours, emphasizing early recognition and aggressive treatment.

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Section: Introductionmentioning

confidence: 99%

Cases of Yolk sac tumor associated with gynecological malignant tumor

Wang

Chen

et al. 2023

Preprint

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First case of endometrial cancer after yolk sac tumor in a patient with Li-Fraumeni syndrome

Liu

et al. 2023

BMC Women's Health

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Background Li-Fraumeni syndrome (LFS) is a rare autosomal dominant disease with high penetrance caused by a germline variant of TP53 gene. We report the first case of endometrial cancer after yolk sac tumor with LFS. Case presentation The presented female patient underwent right adnexectomy at age 23 because of a yolk sac tumor of the ovary. At the age of 27, the patient was diagnosed with endometrial adenocarcinoma, received cytoreductive surgery and chemotherapy. Given that her personal cancer history along with a strong family history of cancer, her father passing away from lung cancer at age 48 and her grandmother dying of ovarian cancer at age 50, the patient was referred for genetic counseling and testing. Genetic screening revealed a heterozygous pathogenic TP53 c.844C > T, p.( R282 W) with NM_000546.5 variant, a class 5 (C5) variant. This is the first reported case of a yolk sac tumor accompanied by subsequent endometrial cancer that is associated with LFS. Conclusions We reported a first case of an endometrial cancer after yolk sac tumor patient with a tumor family history of harboring the germline TP53 pathogenic variation which expanded types of tumor that can be presented in patients with LFS. This case highlights the importance of genetic testing for patients with malignant tumors, as well as patients with a family history of malignant tumors. And our case highlights the necessity of screening for gynecologic tumor in LFS patients.

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Cases of Yolk sac tumor associated with gynecological malignant tumor

Wang

Chen

et al. 2023

BMC Women's Health

View full text Add to dashboard Cite

Background Yolk sac tumour (YST) is the second most common ovarian germ cell tumour and usually presents in children and young women. However, tumours rarely occur as malignant gynaecological tumours with YST components. Case presentation We present one case of endometrioid carcinoma and clear cell carcinoma with YST components and two other cases of YSTs associated with high-grade serous carcinoma of the ovary in females. After surgery and adjuvant chemotherapy, the patient with endometrioid carcinoma had progressive disease and died 20 months later, and the other two were still alive at the last follow-up. Conclusions To our knowledge, these mixed neoplasm associations are unusual, and these cases illustrate the diagnosis and prognosis of YST associated with malignant gynaecological tumours, emphasizing early recognition and aggressive treatment.

show abstract

Ovarian yolk sac tumor

Cited by 3 publications

References 2 publications

Cases of Yolk sac tumor associated with gynecological malignant tumor

Cases of Yolk sac tumor associated with gynecological malignant tumor

First case of endometrial cancer after yolk sac tumor in a patient with Li-Fraumeni syndrome

Cases of Yolk sac tumor associated with gynecological malignant tumor

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