Ovarian tumours, their characterisation and origins and ovarian screening

Maclean, Angus

doi:10.3109/01443615.2012.656159

Cited by 4 publications

(4 citation statements)

References 34 publications

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“…Diagnosis of ovarian cancer at an early stage enables the clinicians to plan an effective treatment; hence a better prognosis can be achieved before the spread of the disease [18]. Despite the widespread use of conventional screening tests, ovarian cancer still has a high mortality rate [19]. More than 80% of the cases are diagnosed at an advanced stage, leading to a low 10% -20% survival rate [20].…”

Section: Discussionmentioning

confidence: 99%

Human Epididymis Protein-4 Gene Expression as a Biomarker in Patients with Ovarian Cancer in Iran

Shahi¹,

Bahrami²,

Fakharian³

et al. 2017

OJCD

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Introduction: Ovarian cancer is one of the most common malignancies in women and the fifth cause of cancer-related deaths in women worldwide. Contrary to the challenges in developing new clinical markers using the conventional methods, recent advances in genomics and proteomics have led to identification of candidate and promising biomarkers for the diagnosis of ovarian cancer. Human epididymis protein 4 (HE4) is such a marker that has recently been reported to correlate with recurrence or progression of epithelial ovarian cancer. The purpose of this study was to measure the expression level of HE4 gene in women with ovarian cancer. Methodology: We evaluated and compared paraffin-embedded tissue samples of 20 ovarian cancer patients with 10 samples from healthy individuals. RNA was initially extracted from the samples and cDNA was synthetized. Gene expression level was then measured using real-time polymerase chain reaction (PCR). Results: Our results demonstrated that HE4 gene expression level was significantly higher in How to cite this paper: samples of patients with ovarian cancer compared with samples from healthy individuals. Moreover, higher levels of HE4 gene expression were associated with more advanced disease and larger tumor size. Conclusion: HE4 gene over-expression has the potential to be used as a biomarker for detecting earlystage ovarian cancer in women. Future more comprehensive studies are needed to confirm our findings.

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Section: Discussionmentioning

confidence: 99%

Human Epididymis Protein-4 Gene Expression as a Biomarker in Patients with Ovarian Cancer in Iran

Shahi¹,

Bahrami²,

Fakharian³

et al. 2017

OJCD

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“…165,275,276 Following a description by Pache and colleagues, 277 the total count of 2 to 10 mm follicles in each ovary constitutes the antral follicle count (AFC). 278 Remarkably, the AFC shows little intracycle variation, 279 and is not affected by hormonal treatments such as the OC pill.…”

Section: Ovariesmentioning

confidence: 99%

Pelvic Imaging in Reproductive Endocrinology

Ziegler¹,

Streuli²,

Santulli³

et al. 2014

Yen &Amp; Jaffe's Reproductive Endocrinology

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“…Гистогенез опухолей яичников, в том числе доброкачественных, до конца не изучен, чем и объясняются разногласия в отношении происхождения той или иной опухоли. Покровный эпителий яичников, яйцеклетки на разных этапах созревания, гранулезные клетки, тека-ткань, лейдиговские клетки, рудиментарные эмбриональные струк туры, тканевые дистопии, неспецифическая соединительная ткань, сосуды, нервы -все эти компоненты могут быть источ никами разнообразных опухолей [4,13].…”

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“…Дизурические явления обусловлены давлением опухоли на мочевой пузырь. Вторым по частоте симптомом можно считать нарушение менструального цикла (29,8%), выражающееся в виде менометроррагии или альгодисменореи [13].…”

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