Ovarian Tumors in Children and Adolescents

Breen, James; Maxson, Wayne S.

doi:10.1097/00003081-197709000-00010

Cited by 157 publications

(60 citation statements)

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“…The percentage of sex-stromal tumours in our series (5%) is lower than suggested in previous series (Breen & Maxson, 1977). However, their percentage seems likely to be an overestimate, possibly because of misclassification of some germ cell tumours (mainly dysgerminomas) as poorlydifferentiated granulosa cell tumours, or to the inclusion of benign tumours of the fibromathecoma group.…”

Section: Histopathological Findingscontrasting

confidence: 81%

“…Among the 13 epithelial cancers, the overall 73% survival rate appears higher than the 30-35% commonly reported in adult-onset cancers, and in other small series of epithelial neoplasms in children (Breen & Maxson, 1977). This is probably attributable both to the clinical stage (9/13 patients were Stage I), and to the high proportion of mucinous adenocarcinoma of borderline malignancy in the cases in our series.…”

Section: Survivalcontrasting

confidence: 65%

“…The few series reporting greater numbers of patients are mostly based on hospital case lists (Breen & Maxson, 1977), from which only unreliable estimates of the relative frequency can be derived, and often include both benign and tPresent address:…”

mentioning

confidence: 99%

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Malignant ovarian tumours in childhood in Britain, 1962-78

Vecchia¹,

Morris²,

Draper³

1983

Br J Cancer

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Less than 10% of the neoplasms occurred at age <5 years, -20% from 5-9, and >70% from 10-14 years. Germ cell neoplasms of greater malignancy (immature teratomas, endodermal sinus tumours) occurred in a significantly higher proportion at younger age ( < 10 years) than dysgerminomas (P =0.01).The overall incidence (- Ovarian tumours are extremely rare in infants and children, representing a small proportion of all ovarian neoplasms (-0.2-0.3% of such tumours occur in girls under 15 years, OPCS, 1980-82). The childhood tumours do, however, include many distinct pathological and clinical entities, with differing epidemiology, therapeutic approach and prognosis.The great variety of types and the structural complexity of the pathological classification have hindered efforts at analytical studies on appropriate numbers: although a considerable number of papers dealing with this subject have been published over the last few years, the great majority are single-case reports. The few series reporting greater numbers of patients are mostly based on hospital case lists (Breen & Maxson, 1977), from which only unreliable estimates of the relative frequency can be derived, and often include both benign and tPresent address:

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Section: Histopathological Findingscontrasting

confidence: 81%

Section: Survivalcontrasting

confidence: 65%

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Malignant ovarian tumours in childhood in Britain, 1962-78

Vecchia¹,

Morris²,

Draper³

1983

Br J Cancer

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“…Dentro del diagnóstico diferencial de estas le- (3,9,11). Las condiciones no neoplá-sicas incluyen los quistes foliculares, quistes del cuerpo lúteo, endometriomas y lesiones vasculares como torsión o infarto hemorrágico (17).…”

Section: Discussionunclassified

“…Tradicionalmente se considera que el 35% de las lesiones ováricas a esta edad son malignas, correspondiendo aproximadamente entre 1% y 1,5% de todos los cánceres infantiles (2)(3)(4)(5). Estas lesiones pueden manifestarse tanto por dolor abdominal, como por el hallazgo al examen de un tumor palpable o por alteraciones endocrinas como la pubertad precoz (6).…”

Section: Introductionunclassified

Tumores Anexiales en Niñas Y Adolescentes: Experiencia Del Hospital Clínico De La Universidad Católica De Chile, 1991-2003

et al. 2006

Rev. chil. obstet. ginecol.

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RESUMENSe analiza retrospectivamente la experiencia de los últimos 13 años en el manejo de la patología anexial quirúrgica en niñas y adolescentes menores de 19 años. Se revisa la forma de presentación clínica y los hallazgos anatopatológicos de 106 pacientes. Del total de lesiones anexiales, un 62% correspondieron a lesiones neoplásicas benignas y malignas, la mayoría de ellas originadas en el ovario. El riesgo de malignidad para las lesiones neoplásicas fue de un 26,7%. La neoplasia ovárica benigna más frecuente fue el teratoma maduro (31,1%). Las neoplasias malignas más frecuentes fueron las originadas en el estroma gonadal específico y en el tejido germinal (en conjunto 37,5% del total de neoplasias malignas). La forma de presentación clínica más frecuente fue el dolor abdominal habitualmente como manifestación de complicación de una neoplasia benigna. La vía de abordaje más frecuente fue por laparotomía y se privilegió la cirugía conservadora para preservar el potencial reproductivo. PALABRAS CLAVES: Adolescencia, infancia, tumores ováricos, patología anexial SUMMARYA retrospective analysis of a thirteen years experience in the surgical management of adnexal mass in girls and teenagers younger than 19 years old was done. We reviewed the clinical course and pathological findings of 106 patients. A 62% of adnexal masses were due to neoplasic formation, the majority of them originated in the ovary. Among the neoplasic lesions, the risk of malignacy was 26.7%. The most frequent benign ovarian neoplasia was the mature teratoma (31.1%). The two more frequent malignant neoplasias were those originated at the specific gonadal stroma and at germinal tissues (together representing 37.5% of malignant tumors). The most frequent symptom of clinical presentation was abdominal pain, as manifestation of a complicated benign neoplasic lesion. The most frequently used surgical approach was laparotomy. The main goal was privileging conservative management to preserve the reproductive potential.

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