Ovarian tumors during infancy and childhood

Groeber, Walter R.

doi:10.1016/s0002-9378(16)35289-9

Cited by 64 publications

(14 citation statements)

References 44 publications

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“…The histotype distribution if the present series appears in broad agreement with previous work (Groeber, 1963;Lindfors, 1971;Norris & Jensen, 1972;De Palo et al, 1978;Lucraft et al, 1980) germ cell tumours representing by far the majority (>80%) of all childhood ovarian cancers.…”

Section: Histopathological Findingssupporting

confidence: 92%

“…That a genetic component represents an important aspect of the risk of developing germ cell neoplasms finds support in three other sets of data: the reported familial occurrence of benign teratomas in women (Hecht et al, 1976); the clustering of germ cell testicular tumours in twins and sibs (Levey & Grabstald, 1975), and their association with HLA DW7 and AIO (De Wolf et al, 1979); and the animal models of germ cell tumours (Graham, 1982).…”

Section: Risk and Associatedfactorsmentioning

confidence: 92%

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Malignant ovarian tumours in childhood in Britain, 1962-78

Vecchia¹,

Morris²,

Draper³

1983

Br J Cancer

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Less than 10% of the neoplasms occurred at age <5 years, -20% from 5-9, and >70% from 10-14 years. Germ cell neoplasms of greater malignancy (immature teratomas, endodermal sinus tumours) occurred in a significantly higher proportion at younger age ( < 10 years) than dysgerminomas (P =0.01).The overall incidence (- Ovarian tumours are extremely rare in infants and children, representing a small proportion of all ovarian neoplasms (-0.2-0.3% of such tumours occur in girls under 15 years, OPCS, 1980-82). The childhood tumours do, however, include many distinct pathological and clinical entities, with differing epidemiology, therapeutic approach and prognosis.The great variety of types and the structural complexity of the pathological classification have hindered efforts at analytical studies on appropriate numbers: although a considerable number of papers dealing with this subject have been published over the last few years, the great majority are single-case reports. The few series reporting greater numbers of patients are mostly based on hospital case lists (Breen & Maxson, 1977), from which only unreliable estimates of the relative frequency can be derived, and often include both benign and tPresent address:

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Section: Histopathological Findingssupporting

confidence: 92%

Section: Risk and Associatedfactorsmentioning

confidence: 92%

Malignant ovarian tumours in childhood in Britain, 1962-78

Vecchia¹,

Morris²,

Draper³

1983

Br J Cancer

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“…This finding is at variance with reports from areas of both high and low frequencies of ovarian cancer [11][12][13][14][15]. This seeming departure from the global experience may, however, simply be due to the very small number of ovarian tumors in this group of patients.…”

Section: Discussioncontrasting

confidence: 78%

Ovarian Tumors in Kuwait

Junaid¹,

Hashad²

1996

Med Principles Pract

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After examination of the case histories of 301 primary ovarian neoplasms in the surgical pathology files of four hospitals in Kuwait from 1984 to 1989, we have reviewed and classified these cases as recommended by the WHO Ovarian Tumors Panel. Standard histopathological techniques were supplemented with special stains in order to increase diagnostic accuracy. Benign cystic teratoma was the single most common tumor in the series. Overall, germ cell tumors were more common than epithelial tumors. However, 75.7% of malignant tumors were epithelial. A higher proportion of epithelial tumors, relatively rare in children and adolescents worldwide, was found in patients under 20 years.

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“…6 However, the incidence of adnexal torsion is higher in young girls. 7,8 This is because, in young girls, the oviduct is relatively long due to the small uterus and the position of the ovary is high with underdeveloped supporting connective tissue surrounding the ovary.…”

Section: Discussionmentioning

confidence: 99%