Ovarian tumor and glomerulopathies: case report and review of the literature

Abstract

We describe a patient who developed nephrotic syndrome in the setting of ovarian tumor. A kidney biopsy showed minimal change nephropathy (MCN). CT scan and MR imaging followed by surgery lead to diagnostic of ovarian dermoid cyst. Surgery combined with corticosteroids resulted in a complete remission of nephrotic syndrome with disappearance of proteinuria after 3 weeks. Ten other cases of ovarian tumor associated with glomerulopathy are reviewed. This is the second case of an ovarian teratoma associated with MCN. Accurate history, physical examination, laboratory data, and kidney biopsy are highlighted in establishing the correct diagnosis in such patients.

A Case Report of Mediastinal Teratoma in a Pediatric Patient With Nephrotic Syndrome: Paraneoplastic Syndrome or Incidental Finding?

“…4 A third case reports a 55-year-old female with NS in the context of mature cystic teratoma of the ovary who achieved complete remission of the NS with steroids within 3 weeks of surgical removal of the tumor. 6 Renal biopsies of the latter two cases confirmed MCD. The last case describes a 16-year-old female with NS and ovarian mature teratoma.…”

“…A second case reports a 36-year-old female with NS in the context of a mature ovarian teratoma who responded briskly to prednisone treatment and tumor resection 4 . A third case reports a 55-year-old female with NS in the context of mature cystic teratoma of the ovary who achieved complete remission of the NS with steroids within 3 weeks of surgical removal of the tumor 6 . Renal biopsies of the latter two cases confirmed MCD.…”

“…NS associated with malignancies is uncommon but well documented, with membranous nephropathy being the most common histologic finding seen in patients with solid tumors and MCD seen more commonly in association with Hodgkin Lymphoma 4 . The literature documents 4 cases of mature teratomas associated with NS, and all 4 cases were associated with ovarian mature teratomas 4–7 . The earliest case published in 1989 describes a 7 year-old female who presented with NS refractory to steroids.…”

“…4 The literature documents 4 cases of mature teratomas associated with NS, and all 4 cases were associated with ovarian mature teratomas. [4][5][6][7] The earliest case published in 1989 describes a 7 year-old female who presented with NS refractory to steroids. She was ultimately found to have an ovarian mass proven to be mature teratoma.…”

Renal dysfunction in individuals with ovarian cancer; a review on current concepts

“…In addition to metastatic lesions and direct extension, other findings on renal histopathology can include chronic kidney disease such as glomerulonephritis or interstitial fibrosis, infectious processes like pyelitis or abscesses, and benign conditions such as angiomyolipoma or oncocytoma. However, these are less common in patients with ovarian cancer (9,18).…”