Ovarian Transposition in Cervical Cancer

Anderson, Barrie; LaPolla, James P.; Turner, Deborah; Chapman, George; Buller, Richard E.

doi:10.1006/gyno.1993.1109

Cited by 113 publications

(47 citation statements)

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“…This is one novel aspect of our study where we have used a random and substantially large control group from general gynaecology clinic to assess the prevalence. In our study, urinary symptoms were experienced by 52 % of patients following radiotherapy with the mean period of 14.14 weeks which was similar to studies done by Covens et al (1993), 13 Anderson et al (1997), 14 Klee et al (2000), 15 and Zola et al (2000). 16 …”

supporting

confidence: 90%

Prevalence of Urogynaecological Symptoms in Survivors of Cervical Cancer in a Tertiary Care Gynaecologic Oncology Clinic of a Developing Country

Pushpalatha¹,

Jb²,

Kumar³

et al. 2015

Women Health Open J

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Background: A lot of research has focussed on bowel symptoms but data is relatively scarce on exact burden of urinary subset of urogynaecological symptoms in survivors of cervical cancer. Aims and objectives: To find out the prevalence of urinary subset of urogynaecological symptoms, in women with advanced cervical carcinoma treated with surgery and/or radiotherapy and comparing same with a control group. Methods: A questionnaire incorporating demographic and urogynaecological (urinary) symptoms (IUGA terminology) was prepared and used to interview over 400 women between October 2008 and June 2010 in a case control observational design; 200 patients (study group) with history of treated cervical cancer, attending gynaecological cancer clinic and 200 patients (control group) with benign conditions attending Gynaecology outpatient clinic were interviewed. The frequency of various urinary problems was correlated with the demographic data and cystoscopic findings wherever appropriate and available. Results: Increased daytime frequency of urination (25% vs. 6%, p=0.0001), dysuria (25% vs. 3%, p= 0.0001) and hematuria (26% vs. 2%, p= 0.0001) were seen more in cervical cancer patients compared to the controls. Nocturia (30% vs. 6%, p=0.6) and urinary hesitancy (7% vs. 2%, p=0.09) did not show any statistically significant difference. Among urinary incontinence, 'any' urinary incontinence (38% vs. 3%, p=0.0001), urge incontinence was seen in 1% vs. 3 %, stress incontinence in 28% vs. 8%, p=0.0001, "continuous (extra urethral origin)" incontinence was seen in 8% vs. 0% and "mixed" incontinence in 1% vs. 2% (all cancer versus control group). Conclusions: There is a high burden of urogynaecological problems in women with carcinoma cervix treated with surgery and/or chemo-radiotherapy as compared to controls.

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supporting

confidence: 90%

Prevalence of Urogynaecological Symptoms in Survivors of Cervical Cancer in a Tertiary Care Gynaecologic Oncology Clinic of a Developing Country

Pushpalatha¹,

Jb²,

Kumar³

et al. 2015

Women Health Open J

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“…This procedure not only has the advantage of sparing fertility, but also of maintaining ovarian function and evading premature menopause 44 . However, it also carries risks, including those associated with surgery, increased ovarian cyst formation, postoperative adhesions, chronic pelvic pain, migration of the ovaries back to their native position, and premature ovarian failure [45][46][47] . Damaged or dysfunctional fallopian tubes may also preclude a spontaneous pregnancy.…”

Section: Ovarian Transposition and Gonadal Shieldingmentioning

confidence: 99%

Oncofertility in Canada: Gonadal Protection and Fertility-Sparing Strategies

Ronn

Holzer

2013

Current Oncology

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Background: Cancer can be a devastating diagnosis. In particular, malignancy and its indicated treatments have profoundly negative effects on the fertility of young cancer patients. Oncofertility has emerged as a new interdisciplinary field to address the issue of gonadotoxicity associated with cancer therapies and to facilitate fertility preservation. In Canada, fertility issues are often inadequately addressed despite the availability of resources. The goal of this four-part series is to facilitate systemic improvements in fertility preservation for adolescent and young adult Canadians with a new diagnosis of cancer. Methods: Here, we review the fertility preservation measures currently available. Medical and surgical strategies are both outlined. Results: Fertility-preserving strategies and gonadal protection have demonstrated variable success in a number of approaches. The value of hormone suppression is still in question for women. Progestins for endometrial cancer and alternative chemotherapies are other medical approaches. Gonadal shielding and protective surgical approaches have also been attempted. Conclusions: The techniques discussed here may be selectively considered and integrated into patient care in an attempt to preserve future fertility before initiating cancer treatment.

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“…5 Surgical techniques were hence devised to transpose the ovaries out of the radiation field in the pelvis and methods of abdominal shielding during RT were developed to reduce the damage to the ovaries. 6,7 This prospective observational study was done to objectively evaluate the ovarian function after lateral ovarian transposition (LOT) during radical hysterectomy (RH) in patients with operable ca cervix with and without RT over a period of 12 months.…”

Section: Introductionmentioning

confidence: 99%

Ovarian preservation with lateral ovarian transposition in operable Ca cervix: experience at a tertiary care center

Jose

Singh²,

Sinha³

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: The benefits of ovarian preservation during radical surgery for ca cervix in premenopausal patients far outweigh the risk of ovarian disease later. However, adjuvant pelvic radiotherapy damages retained ovaries. Mobilization and transposition of these ovaries during surgery outside the pelvis prevents or reduces radiation damage to these ovaries. A prospective observational study was conducted to objectively study the effect of ovarian preservation with Lateral Ovarian Transposition (LOT) on ovarian function on operated patients of Ca cervix.Methods: All pre-menopausal patients of Ca cervix <45 years, planned for surgery underwent FSH levels to assess ovarian function and were screened for ovarian disease. Eligible patients who consented underwent ovarian retention (OR) with LOT during surgery. Adjuvant treatments as indicated was administered and all patients were followed up at 3, 6 and 12 months after surgery for subjective (symptoms) and objective (FSH) evidence of ovarian failure.Results: LOT could be successfully performed in all patients. Though the mean FSH values did show a rise after surgery, this was more pronounced in patients receiving radiotherapy (RT). Ovarian function continued normally in 63% of all patients with 72% retaining ovarian function when RT was not administered. Hot flashes (HF) and Vaginal dryness(VD) were the most common symptoms but its onset was gradual and symptoms milder compared to surgical menopause.Conclusions: LOT is an oncologicaly safe, technically feasible and reasonably effective procedure for preserving ovarian function during surgical treatment and even after adjuvant RT in Ca Cervix and should be offered to eligible premenopausal patients.

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Ovarian Transposition in Cervical Cancer

Cited by 113 publications

References 0 publications

Prevalence of Urogynaecological Symptoms in Survivors of Cervical Cancer in a Tertiary Care Gynaecologic Oncology Clinic of a Developing Country

Prevalence of Urogynaecological Symptoms in Survivors of Cervical Cancer in a Tertiary Care Gynaecologic Oncology Clinic of a Developing Country

Oncofertility in Canada: Gonadal Protection and Fertility-Sparing Strategies

Ovarian preservation with lateral ovarian transposition in operable Ca cervix: experience at a tertiary care center

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