Ovarian Transplantation between Monozygotic Twins Discordant for Premature Ovarian Failure

Abstract

Monozygotic 24-year-old twins presented with discordant ovarian function. One had had premature ovarian failure at the age of 14 years, whereas her sister had normal ovaries and three naturally conceived children. After unsuccessful egg-donation therapy, the sterile twin received a transplant of ovarian cortical tissue from her sister by means of a minilaparotomy. Within three months after transplantation, the recipient's cycles resumed and serum gonadotropin levels fell to the normal range. During the second cycle, she conceived, and her pregnancy progressed uneventfully. At 38 weeks' gestation, she delivered a healthy-appearing female infant.

Premature Ovarian Failure

“…Cryopreserved embryos have also been used to achieve pregnancy in POF with a high pregnancy rate of 30% per transfer [55]. Recently Silber et al [56] described a successful pregnancy following ovarian transplantation between monozygotic twins discordant for POF.…”

Alginate scaffold for organ culture of cryopreserved-thawed human ovarian cortical follicles

“…However, many have ovarian failure and premature menopause as a consequence of the radiation and chemotherapy [1]. Among the limited options currently available for fertility preservation in these patients is cryopreservation of ovarian cortical tissue containing immature primordial follicles followed by autotransplantation [2][3][4][5]. However, this procedure carries the risk of reintroducing hematological or other malignancies [6][7][8][9].…”

Live birth after allografting of ovarian cortex between monozygotic twins with Turner syndrome (45,XO/46,XX mosaicism) and discordant ovarian function

“…Allotransplantation of ovarian cortex between genetically identical or nonidentical sisters has yielded pregnancies and live births (4)(5)(6)(7)(8)(9). In this report, we report the first live birth after allografting between monozygotic twins with 45,XO/46,XX mosaicism and discordant ovarian function.…”