Ovarian toxicity of benzo(a)pyrene and metabolites in mice

Ovarian reserve and in vitro fertilization cycles outcome according to women smoking status and stimulation regimen

“…However, some studies based on animal models yielded some confluent results. Indeed, smoke components, such as benzopyrene or cadmium, have been shown to cause follicle loss in ovaries [12,13,[17][18][19]. Then, it can be hypothesized that tobacco has two main deleterious effects on ovaries: one direct via direct follicular atresia, another indirect through hormonal impairment with early FSH rise leading to accelerated recruitment of follicles, these two mechanisms being intricate.…”

The Gulf Oil Spill

“…Data from animal studies indicate that oocyte and follicle destruction occurs following dosing with PAHs (Mattison et al 1989;Miller et al 1992;Urso and Gengozian 1980;Urso and Johnson 1987 (Swartz and Mattison 1985). However, the doses that produced the effects discussed above are high relative to expected environmental exposures to PAHs.…”

Molecular interactions of the aryl hydrocarbon receptor and its biological and toxicological relevance for reproduction

“…It has been known for over two decades now that exposure of female mice to AhR ligands causes a rapid depletion of primordial and primary oocytes (Mattison et al 1989) and these ovotoxic effects can be prevented by selective AhR antagonists (Shiromizu & Mattison 1985). Thus, it is tempting to suggest that in the ovary genes involved in the regulation of cell death are prime targets for the transcriptional regulation by the activated AhR.…”