Ovarian tissue remodeling: role of matrix metalloproteinases and their inhibitors

Smith, Michael F.; Ricke, William A.; Bakke, Leanne J.; Dow, Mark P.D.; Smith, George W.

doi:10.1016/s0303-7207(02)00054-0

Cited by 115 publications

(106 citation statements)

References 86 publications

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“…Perhaps first among those is timp3, which had an 8.5-fold difference in expression between the vtg and prevtg histoclasses and an overall p-value of 0.000019. Functionally, matrix metalloproteinases are known to play a key role in the extracellular matrix remodeling that accompanies follicular growth, atresia, and/or ovulation (Smith et al, 2002). Tissue inhibitors of metalloproteinases, like TIMP3, modulate the activity matrix metalloproteinases (Smith et al, 2002).…”

Section: Notable Differentially Expressed Genesmentioning

confidence: 99%

“…Functionally, matrix metalloproteinases are known to play a key role in the extracellular matrix remodeling that accompanies follicular growth, atresia, and/or ovulation (Smith et al, 2002). Tissue inhibitors of metalloproteinases, like TIMP3, modulate the activity matrix metalloproteinases (Smith et al, 2002). In rats, TIMP3 has been specifically implicated in regulation of fatty acid synthesis, steroidogenesis, and protein turnover in granulosa cells through siRNA modulation of its expression (Li and Curry, 2009).…”

Section: Notable Differentially Expressed Genesmentioning

confidence: 99%

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Influence of ovarian stage on transcript profiles in fathead minnow (Pimephales promelas) ovary tissue

et al. 2010

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Section: Notable Differentially Expressed Genesmentioning

confidence: 99%

Section: Notable Differentially Expressed Genesmentioning

confidence: 99%

Influence of ovarian stage on transcript profiles in fathead minnow (Pimephales promelas) ovary tissue

et al. 2010

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“…There is a shift from estrogen to progesterone synthesis, thinning and folding of the follicle wall, and dispersion of the granulosa cell layer (Smith et al 1994, Murphy et al 2001. Growth factors, proteases, and protease inhibitors coordinate tissue remodeling and angiogenesis that are essential for ovulation and the formation of the corpus luteum (Smith et al 2002, Tamanini & DeAmbrogi 2004. Perhaps, the most notable morphological change occurs within the microvasculature of the theca cell layer where there is hyperemia, edema, and extravagination of erythrocytes (Smith et al 1994, Murphy et al 2001.…”

Section: Introductionmentioning

confidence: 99%

Luteinization of porcine preovulatory follicles leads to systematic changes in follicular gene expression

Ağca

Ries²,

Kolath³

et al. 2006

Reproduction

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The LH surge initiates the luteinization of preovulatory follicles and causes hormonal and structural changes that ultimately lead to ovulation and the formation of corpora lutea. The objective of the study was to examine gene expression in ovarian follicles (nZ11) collected from pigs (Sus scrofa domestica) approaching estrus (estrogenic preovulatory follicle; nZ6 follicles from two sows) and in ovarian follicles collected from pigs on the second day of estrus (preovulatory follicles that were luteinized but had not ovulated; nZ5 follicles from two sows). The follicular status within each follicle was confirmed by follicular fluid analyses of estradiol and progesterone ratios. Microarrays were made from expressed sequence tags that were isolated from cDNA libraries of porcine ovary. Gene expression was measured by hybridization of fluorescently labeled cDNA (preovulatory estrogenic or -luteinized) to the microarray. Microarray analyses detected 107 and 43 genes whose expression was decreased or increased (respectively) during the transition from preovulatory estrogenic to -luteinized (P!0.01). Cells within preovulatory estrogenic follicles had a gene-expression profile of proliferative and metabolically active cells that were responding to oxidative stress. Cells within preovulatory luteinized follicles had a gene-expression profile of nonproliferative and migratory cells with angiogenic properties. Approximately, 40% of the discovered genes had unknown function.

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“…MMPs are involved in the turnover of extracellular matrix structural proteins, and appear to play roles in cell matrix remodeling, cell growth and apoptosis during both normal developmental and pathological processes of tissue restructuring such as wound healing. TIMPs are the major regulators of the activities of MMPs and the balance between MMPs and TIMPs is considered to be a major factor determining the turnover of extracellular matrix proteins (Gomez et al, 1997;Smith et al, 2002). TIMP-1 over-expression is associated with attenuated tumor growth, reduced metastasis and suppression of angiogenesis (Bloomston et al, 2002;Ikenaka et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

ACTH induces TIMP-1 expression and inhibits collagenase in adrenal cortex cells

Reichenstein

Reich

Lehoux

et al. 2004

Molecular and Cellular Endocrinology

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To identify genes that are induced by corticotropin (ACTH) in adrenal cortex cells, we carried out a differential hybridization screening of adrenal cortex cDNA libraries. Some of the clones we identified represented tissue inhibitor of metalloproteinase 1 (TIMP-1) mRNA. We examined ACTH dependence of the expression of TIMP-1 in vitro in cultured bovine adrenocortical cells, and in ACTH-treated rats. Northern blot analysis of total RNA from cells showed that the level of TIMP-1 mRNA increases sharply within 3 h after ACTH stimulation. Since TIMP-1 inhibits some cell matrix metalloproteinases (MMPs) of the collagenase type, we examined the effect of ACTH on collagenase activity in bovine adrenocortical cells. Exposure of confluent cultures to ACTH for 24 h showed dose-dependent inhibition of collagenase activity. Northern blot analysis of total RNA from rat adrenal zona fasciculata-reticularis and zona glomerulosa showed that in both of these zones TIMP-1 expression was induced within 12 h after ACTH injection. Long-term (9 days) treatment with ACTH increased TIMP-1 mRNA levels nearly sixfold in zona fasciculata-reticularis. Overall, our results show that ACTH causes induction of TIMP-1 and suppression of collagenase activity, and suggest that ACTH may modulate the activities of MMPs and hence cell matrix remodeling.

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Ovarian tissue remodeling: role of matrix metalloproteinases and their inhibitors

Cited by 115 publications

References 86 publications

Influence of ovarian stage on transcript profiles in fathead minnow (Pimephales promelas) ovary tissue

Influence of ovarian stage on transcript profiles in fathead minnow (Pimephales promelas) ovary tissue

Luteinization of porcine preovulatory follicles leads to systematic changes in follicular gene expression

ACTH induces TIMP-1 expression and inhibits collagenase in adrenal cortex cells

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