Ovarian tissue cryopreservation in girls undergoing haematopoietic stem cell transplant: experience of a single centre

Biasin, Eleonora; Salvagno, Francesca; Berger, Massimo; Nesi, Francesca; Quarello, Paola; Vassallo, Elena; Evangelista, Francesca; Marchino, Gian Luigi; Revelli, Alberto; Benedetto, Chiara

doi:10.1038/bmt.2015.111

Cited by 24 publications

(23 citation statements)

References 62 publications

(69 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Follicular count at the time of preservation is another important factor influencing ovarian tissue transplantation outcome. Biasin et al confirmed that the functionality of ovarian tissue transplants with enough follicle counts was continued for almost 7 years with an average of 4–5 years [25]. In line with these findings, Silber reported that the duration of the ovarian function is directly linked to the ovarian reserve (primordial and antral follicle count) at the time of preservation [11].…”

Section: Discussionmentioning

confidence: 88%

“…These findings clearly illustrate that ovarian preservation at early ages with a high follicular reserve will increase the probability of success after transplantation. Indeed ovarian tissue preservation is believed to be the foremost clinical procedure for saving fertility in patients with pre-pubertal cancer, in which egg or embryo freezing is not possible [25].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ovarian function and reproductive outcome after ovarian tissue transplantation: a systematic review

et al. 2019

View full text Add to dashboard Cite

The aim of this systematic review study is to summarize the current knowledge of ovarian tissue transplantation and provide insight on ovarian function, fertility and reproductive outcome following ovarian tissue transplantation. Relevant studies were identified by searching through PubMed, Cochrane Library, Embase, ProQuest, and Scopus databases until August 2018. Ovarian function by examination of the hormonal level was evaluated, together with follicular growth, the return of menstrual cycle and assessment of reproductive consequences: pregnancy, miscarriage rates and live birth after transplantation. Studies including female patients aged between 22 and 49 years that were subjected to ovarian tissue transplantation were considered. A total of 1185 studies were identified in the primary search. Titles and abstracts were screened for assessment of the inclusion criteria. Finally, twenty-five articles met the criteria and were included in this study. In general, 70% of patients that underwent ovarian tissue transplantation had ovarian and endocrine function restoration as well as follicular growth. Pregnancy was reported with 52% of the patients. The available evidence suggests that ovarian tissue transplantation is a useful and an applied approach to restore hormonal function, endocrine balance and eventually fertility outcomes in patients that are predisposed to lose their fertility, diagnosed with premature ovarian failure (POF), as well as women undergoing cancer treatments. Identification of the techniques with the lowest invasions for follicular and oocyte development after ovarian tissue transplantation aiming to reduce probable adverse effects after treatment is indispensable.

show abstract

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Ovarian function and reproductive outcome after ovarian tissue transplantation: a systematic review

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The majority of these pregnancies occurred after natural conception, which is the main advantage of the ovarian tissue cryopreservation compared to oocyte and embryo cryopreservation [205]. Besides the restoration of fertility, the endocrine function of ovarian tissue was also successfully restored with the main duration of about 4-5 years after transplantation, with graft functioning up to several years [206], making this procedure an option to delay menopause [207].…”

Section: Methods For Female Fertility Preservationmentioning

confidence: 99%

Winter is coming: the future of cryopreservation

et al. 2021

View full text Add to dashboard Cite

The preservative effects of low temperature on biological materials have been long recognised, and cryopreservation is now widely used in biomedicine, including in organ transplantation, regenerative medicine and drug discovery. The lack of organs for transplantation constitutes a major medical challenge, stemming largely from the inability to preserve donated organs until a suitable recipient is found. Here, we review the latest cryopreservation methods and applications. We describe the main challenges—scaling up to large volumes and complex tissues, preventing ice formation and mitigating cryoprotectant toxicity—discuss advantages and disadvantages of current methods and outline prospects for the future of the field.

show abstract

“…In literature, only a few reports described IVF treatment in patients undergoing autotransplantation of frozenthawed ovarian tissue to orthotopic or heterotopic sites for fertility preservation (Biasin et al, 2015;Burmeister et al, 2013;Dolmans et al, 2009;Donnez et al, 2011;Kim, 2012;Revel et al, 2011;Revelli et al, 2013;Schmidt et al, 2011). To date, there is no information regarding reproductive outcomes of IVF treatment in POI women with intermittent follicular development.…”

Section: Introductionmentioning

confidence: 99%

Retrospective analysis of reproductive outcomes in women with primary ovarian insufficiency showing intermittent follicular development

Chen¹,

Chen²,

et al. 2016

Reproductive BioMedicine Online

View full text Add to dashboard Cite

The aim of this retrospective study was to explore the reproductive outcomes of IVF treatment in women with primary ovarian insufficiency (POI) showing intermittent follicular development. A total of 44 POI women with normal karyotype and absent autoimmunity, attending the centre for fertility treatment at Nanfang Hospital, Guangzhou from March 2009 to March 2011, were identified as suitable for inclusion in this study. Out of 44 women, 20 (20/44; 45.5%) had growing follicles and 13 underwent 27 oocyte retrievals. The empty follicle rate per oocyte retrieval was 70.4% (19/27); eight oocytes were recovered: one (12.5%) germinal vesicle (GV), two (25.0%) metaphase I (MI), one (12.5%) metaphase II (MII), and four (50.0%) atretic. One MI oocyte matured in vitro and two women had embryo transfer. Only the woman with the MI oocyte matured in vitro conceived, giving birth to a healthy baby at term. These results suggest that intermittent follicular development is common in women with POI but most of the developed follicles are empty or contain atretic oocytes. The pregnancy rate remains very low for IVF treatment.

show abstract

Ovarian tissue cryopreservation in girls undergoing haematopoietic stem cell transplant: experience of a single centre

Cited by 24 publications

References 62 publications

Ovarian function and reproductive outcome after ovarian tissue transplantation: a systematic review

Ovarian function and reproductive outcome after ovarian tissue transplantation: a systematic review

Winter is coming: the future of cryopreservation

Retrospective analysis of reproductive outcomes in women with primary ovarian insufficiency showing intermittent follicular development

Contact Info

Product

Resources

About