Ovarian tissue cryopreservation: a committee opinion

doi:10.1016/j.fertnstert.2014.02.052

Cited by 206 publications

(110 citation statements)

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“…At the time of this study, no IRB approved protocol for ovarian tissue cryopreservation, an experimental technique for fertility preservation [22], was available at our institution. Patients were counseled that this option was available elsewhere, however to our knowledge none chose to pursue it.…”

Section: Stimulation Cryopreservation Thaw and Embryo Transfer Protmentioning

confidence: 99%

Ovarian stimulation and in-vitro fertilization outcomes of cancer patients undergoing fertility preservation compared to age matched controls: a 17-year experience

Cardozo

Thomson

Karmon

et al. 2015

J Assist Reprod Genet

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Purpose To compare the in-vitro fertilization (IVF) outcomes of cancer patients who underwent oocyte retrieval and embryo/ oocyte cryopreservation prior to gonadotoxic therapy to those of age and time-matched controls with tubal factor infertility. Methods All cancer patients who underwent embryo/oocyte cryopreservation at our institution from 1997 to 2014 were reviewed. Primary outcomes were total dose of gonadotropins used, number of oocytes retrieved, and number of 2pn embryos obtained. Outcomes were compared to age-matched controls with tubal-factor infertility who underwent a fresh embryo transfer within the same relative time period as the IVF cycle of the cancer patient. Results Sixty-three cancer patients underwent 65 IVF cycles, and 21 returned for frozen embryo transfer. One hundred twenty-two age-matched controls underwent IVF cycles with fresh transfer, and 23 returned for frozen embryo transfer. No difference was seen between cancer patients and controls with respect to total ampules of gonadotropin used (38.0 vs. 35.6 respectively; p=0.28), number of oocytes retrieved (12.4 vs. 10.9 respectively; p=0.36) and number of 2pn embryos obtained (6.6 vs. 7.1 respectively; p=0.11). Cumulative pregnancy rate per transfer for cancer patients compared to controls was 37 vs. 43 % respectively (p=0.49) and cumulative live birth rate per transfer was 30 vs. 32 % respectively (p=0.85). Cancer patients had a higher likelihood of live birth resulting in twins (44 vs. 14 %; p=0.035). Conclusions Most IVF outcomes appear comparable for cancer patients and age-matched controls. Higher twin pregnancy rates in cancer patients may reflect lack of underlying infertility or need for cancer-specific transfer guidelines.

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Section: Stimulation Cryopreservation Thaw and Embryo Transfer Protmentioning

confidence: 99%

Ovarian stimulation and in-vitro fertilization outcomes of cancer patients undergoing fertility preservation compared to age matched controls: a 17-year experience

Cardozo

Thomson

Karmon

et al. 2015

J Assist Reprod Genet

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“…Two additional available methods include 1) ovarian tissue cryopreservation with the intent of future implantation, and 2) retrieval of immature oocytes, in-vitro maturation, and vitrification (rapid cooling to avoid ice formation) (4, 9). While still undergoing refinement, these are the only approaches available to pre-pubertal girls as they obviate the need for ovarian stimulation and sexual maturity (4, 9).…”

Section: Part I: Fertility-sparing Using Assisted Reproductive Technomentioning

confidence: 99%

Section: Part I: Fertility-sparing Using Assisted Reproductive Technomentioning

confidence: 99%

“…While still undergoing refinement, these are the only approaches available to pre-pubertal girls as they obviate the need for ovarian stimulation and sexual maturity (4, 9). The potential concern is reintroduction of cancer cells during implantation (4, 9). Thus, this approach is avoided in patients with an inherent predisposition to ovarian cancer or malignancies with moderate-to-high risk of ovarian metastases (e.g., leukemia, Ewing’s sarcoma, neuroblastoma, gastric, colon, and breast cancers) (9, 10).…”

Section: Part I: Fertility-sparing Using Assisted Reproductive Technomentioning

confidence: 99%

“…The potential concern is reintroduction of cancer cells during implantation (4, 9). Thus, this approach is avoided in patients with an inherent predisposition to ovarian cancer or malignancies with moderate-to-high risk of ovarian metastases (e.g., leukemia, Ewing’s sarcoma, neuroblastoma, gastric, colon, and breast cancers) (9, 10). …”

Section: Part I: Fertility-sparing Using Assisted Reproductive Technomentioning

confidence: 99%

See 2 more Smart Citations

Fertility-sparing for young patients with gynecologic cancer: How MRI can guide patient selection prior to conservative management

et al. 2017

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Historically, cancer treatment has emphasized measures for the “cure” regardless of the long-term consequences. Advances in cancer detection and treatment have resulted in improved outcomes bringing to the fore various quality of life considerations including future fertility. For many young cancer patients, fertility preservation is now an integral component of clinical decision-making and treatment design. Optimal fertility-sparing options for young patients with gynecologic cancer are influenced by patient age, primary cancer, treatment regimens, and patient preferences. Possible approaches include embryo or oocyte cryopreservation, ovarian transposition, conservative surgery, and conservative medical treatment to delay radical surgery. These may be used alone or in combination to maximize fertility preservation. Awareness of the various fertility-sparing options, eligibility criteria, and the central role of Magnetic Resonance Imaging (MRI) in the proper selection of patients will enable radiologists to produce complete clinically relevant imaging reports and serve as effective consultants to referring clinicians. Knowledge of the potential imaging pitfalls is essential to avoid misinterpretation and guide appropriate management.

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