Ovarian stromal tumors containing leydig cells.I. Stromal-leydig cell tumor and non-neoplastic transformation of ovarian stroma to leydig cells

Sternberg, William H.; Roth, Lawrence M.

doi:10.1002/1097-0142(197310)32:4<940::aid-cncr2820320428>3.0.co;2-5

Cited by 56 publications

(1 citation statement)

References 13 publications

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“…This supposition is supported by the finding of LCH in postmenopausal patients with hyperandrogenism, however, it does not account for all cases, such as our second patient. [ 8 , 9 , 10 , 11 ] It has also been postulated that hyperplasia may be triggered in response to increased pressure from adjacent ovarian tumors or cysts [ 12 , 6 , 13 ]. There have been at least five case reports of LCH in association with serous cystadenomas or fibromas.…”

Section: Discussionmentioning

confidence: 99%

Varying Phenotypes of Leydig Cell Hyperplasia of the Ovary: Two Case Reports

Caulkins

Ricciuti

Desouki

et al. 2023

Case Reports in Obstetrics and Gynecology

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Leydig cell hyperplasia (LCH) is a rare cause of hyperandrogenism that has been described only in case reports. The cases presented herein contrast the traditional presentation of LCH with an affected asymptomatic individual. The first case involves a 74-year-old woman presenting with symptomatic hyperandrogenism, whose symptoms resolved after bilateral salpingo-oophorectomy (BSO). The second patient presented with postmenopausal bleeding and an abdominal mass. Following total abdominal hysterectomy (TAH) and BSO, pathology showed ovarian LCH with concomitant endometrial cancer. The diagnosis of LCH is complex and requires careful investigation of many differential diagnoses. Incidentally discovered LCH may shed light on evolution and disease progression. Cases of LCH found in the setting of endometrial pathology may have implications on other states of testosterone excess.

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Section: Discussionmentioning

confidence: 99%

Varying Phenotypes of Leydig Cell Hyperplasia of the Ovary: Two Case Reports

Caulkins

Ricciuti

Desouki

et al. 2023

Case Reports in Obstetrics and Gynecology

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Evidence that Leydig cells in Sertoli-Leydig cell tumors have a reactive rather than a neoplastic profile

Mooney

Man

Bratthauer

et al. 1999

Cancer

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Ovarian stromal tumors containing leydig cells.II. Pure leydig cell tumor, non-hilar type

Roth

Sternberg

1973

Cancer

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Rare benign neoplasms occur which are composed solely of Leydig cells derived from ovarian stroma rather than from preexisting hilus cells of the mesovarium. Two such tumors are described and two are noted in the literature although others, difficult to identify, undoubtedly exist. They are closely related to the stromal-Leydig cell tumor but are not multifocal and lack the thecoma-like stromal component. Both types of neoplasm occur in menopausal or post-menopausal women and are likely to be associated with masculinization. They are related to each other as the stromal luteoma is related to the partly luteinized theca cell tumor. The presence of crystalloids of Reinke in some of the lipid cells identifies the lipid cell component of the tumor as Leydig cells. Similar tumors lacking crystalloids, in fact, may be Leydig cell tumors but in the absence of definitive diagnostic criteria are best classified as lutein cell tumors. DISTINCTIVE FORM OF OVARIAN LEYDICA cell tumor appears to be derived from the specific ovarian stroma and does not originate in preexisting hilus cells. It can be distinguished from the usual form of ovarian Leydig cell tumor that arises from the hilus,lo from the Sertoli-Leydig cell tumor, and also from another recently described ovarian tumor containing Leydig cells known as the stromal-Leydig cell tumor.1' In both of our cases, characteristic crystalloids of Reinke were identified within the tumor cells. T h e non-neoplastic portions of the ovaries showed stromal hyperplasia and contained foci of lutein-like stromal cells. We refer to this lesion as a pure Leydig cell tumor, nonhilar type.

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Ovarian stromal tumors containing leydig cells.I. Stromal-leydig cell tumor and non-neoplastic transformation of ovarian stroma to leydig cells

Cited by 56 publications

References 13 publications

Varying Phenotypes of Leydig Cell Hyperplasia of the Ovary: Two Case Reports

Varying Phenotypes of Leydig Cell Hyperplasia of the Ovary: Two Case Reports

Evidence that Leydig cells in Sertoli-Leydig cell tumors have a reactive rather than a neoplastic profile

Ovarian stromal tumors containing leydig cells.II. Pure leydig cell tumor, non-hilar type

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