Ovarian Stockpiling in Polycystic Ovary Syndrome, Infertility, and the Combined Use of Rosiglitazone and Metformin

Elhadd, Tarik; Fiad, T. M.; Meer, Lorna

doi:10.2337/dc06-1114

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…Existen reportes de casos de embarazos exitosos logrados a partir de la incorporación de TZDs al esquema terapéutico de mujeres con diabetes y SOP 84,85 . Sin embargo, en el metaanálisis de Tang et al se informó la ausencia de datos disponibles sobre la tasa de embarazo y nacimientos para TZDs en estudios de calidad analizados.…”

Section: Tiazolidinedionas (Tzds)unclassified

Trastornos De La Fertilidad en La Mujer Con Diabetes Tipo 1 Y 2

Pomares

Martı́n

Maccio³

et al. 2014

Rev. Soc. Argent. Diabetes

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La fertilidad es la capacidad fisiológica de una mujer, de un hombre o de una pareja para producir un hijo vivo. Son múltiples los factores que pueden interferir en este complejo proceso. La diabetes mellitus -como enfermedad crónica que afecta el metabolismo- puede alterar dicho proceso en sus distintas etapas. En la siguiente revisión analizamos las evidencias existentes acerca de los distintos aspectos que relacionan la diabetes con las alteraciones de la fertilidad femenina.

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Section: Tiazolidinedionas (Tzds)unclassified

Trastornos De La Fertilidad en La Mujer Con Diabetes Tipo 1 Y 2

Pomares

Martı́n

Maccio³

et al. 2014

Rev. Soc. Argent. Diabetes

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“…Polycystic ovary syndrome (PCOS) is caused by the hormonal environment in utero, abnormal metabolism, and genetics, and its incidence is related to race and eating habits [1][2][3]. The disease is very common in women of childbearing age, and its common clinical symptoms include menstrual disorders, hirsutism, obesity, and infertility [4][5][6][7][8][9][10]. Among them, according to relevant statistics, obesity accounts for 30% to 60% of PCOS patients.…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics Analysis of ceRNA Network Related to Polycystic Ovarian Syndrome

Tan

2021

Computational and Mathematical Methods in Medicine

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Introduction. Polycystic ovary syndrome (PCOS) is caused by the hormonal environment in utero, abnormal metabolism, and genetics, and it is common in women of childbearing age. A large number of studies have reported that lncRNA is important to the biological process of cancer and can be used as a potential prognostic biomarker. Thus, we studied lncRNAs’ roles in PCOS in this article. Methods. We obtained mRNAs’, miRNAs’, and lncRNAs’ expression profiles in PCOS specimens and normal specimens from the National Biotechnology Information Gene Expression Comprehensive Center database. The EdgeR software package is used to distinguish the differentially expressed lncRNAs, miRNAs, and mRNAs. Functional enrichment analysis was carried out by the clusterProfiler R Package, and the lncRNA-miRNA-mRNA interaction ceRNA network was built in Cytoscape plug-in BiNGO and Database for Annotation, Visualization, and Integration Discovery (DAVID), respectively. Results. We distinguished differentially expressed RNAs, including 1087 lncRNAs, 14 miRNAs, and 566 mRNAs in PCOS. Among them, 410 lncRNAs, 11 miRNAs, and 185 mRNAs were contained in the ceRNA regulatory network. The outcomes from Gene Ontology (GO) analysis showed that the differentially expressed mRNAs (DEMs) were mainly enriched in response to the maternal process involved in female pregnancy, morphogenesis of embryonic epithelium, and the intracellular steroid hormone receptor signaling pathway. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis data showed that DEMs were primarily enriched in pathways related to the TGF-β signaling pathway, Type I diabetes mellitus, and glycolysis/gluconeogenesis. In addition, we chose NONHSAT123397, ENST00000564619, and NONHSAT077997 as key lncRNAs due to their high bearing on PCOS. Conclusion. ceRNA networks play an important role in PCOS. The research indicated that specific lncRNAs were related to PCOS development. NONHSAT123397, ENST00000564619, and NONHSAT077997 could be regarded as potential diagnostic mechanisms and biomarkers for PCOS. This discovery might provide more effective and more novel insights into the mechanisms of PCOS worthy of further exploration.

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Mosby's Guide to Women's Health

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Ovarian Stockpiling in Polycystic Ovary Syndrome, Infertility, and the Combined Use of Rosiglitazone and Metformin

Cited by 5 publications

References 6 publications

Trastornos De La Fertilidad en La Mujer Con Diabetes Tipo 1 Y 2

Trastornos De La Fertilidad en La Mujer Con Diabetes Tipo 1 Y 2

Bioinformatics Analysis of ceRNA Network Related to Polycystic Ovarian Syndrome

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