Ovarian Sertoli-Leydig cell tumors. A retrospective MITO study

Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists

“…The most important prognostic factors are the stage and degree of histologic differentiation (3,13,48). In a previous report by Sigismondi et al (49), five-year survival rates of 92.3% and 33.3% were reported for patients with stage I and stage ≥2 disease, respectively. In the same report, patients with well-differentiated tumors had a five-year survival rate of 100% versus 77.8% for patients with moderately and poorly differentiated tumors.…”

“…In contrast to GCTs, which tend to recur late, malignant SLCTs usually recur early in the pelvic and abdominal cavity, with a reported relapse rate of 71.4% within two years after diagnosis (49).…”

Poorly Differentiated Ovarian Sertoli-Leydig Cell Tumor in a Postmenopausal Woman: Case Report

“…1 Son çalışmalara göre, iyi diferansiye SLHT'ler benign ve beş yıllık yaşam oranı %100; orta ve az diferansiye SLHT'ler ise malign olarak kabul edilmektedir ve beş yıllık yaşam oranları %77,8'dir. 17 Bu nedenle genç hastalarda gelişen iyi diferansiye SLHT'de tek taraflı salpingo-ooferektomi ile fertilitenin korunması önemlidir. Az diferansiye SLHT'de salpingoooferektomiye ilaveten omentektomi ve pelvikparaaortik lenf nodu diseksiyonu ile beraber yine fertilite koruyucu evreleme cerrahisi önerilmekte-dir.…”

Large moderately-differentiated ovarian Sertoli-Leydig cell tumor in a 13-year-old female: A case report

“…The prognosis of ovarian Sertoli-Leydig cell tumors is significantly correlated with the degree of tumor differentiation and the tumor extent. The overall 5-year survival rate for moderately-differentiated (grade 2) and poorly-differentiated (grade 3) Sertoli-Leydig cell tumors is 80% (14). Long-term follow-up is highly advised in such patients.…”