Ovarian seromucinous cystadenomas and adenofibromas: first report of a case series

Abstract

Aims To report a series of benign ovarian seromucinous neoplasms, an uncommon and hitherto poorly described category of tumours included in the current 2014 World Health Organisation classification of tumours of the female reproductive organs. Methods and results We report the clinicopathological features of a series of 22 benign ovarian seromucinous neoplasms (cystadenomas and adenofibromas or admixtures). The neoplasms occurred in patients aged 32–83 years (mean = 62, median = 65.5) and involved the left ovary (n = 14), the right ovary (n = 6) or both ovaries (n = 2). There was a common association with endometrioid elements (endometrioid differentiation within the cystadenoma/adenofibroma and/or endometriosis) and other endometriosis‐associated neoplasms. Conclusions We speculate that some of these represent benign ovarian endometrioid neoplasms with foci of mucinous and/or serous differentiation, while others represent true mixed neoplasms.

Bilateral Ovarian huge Benign Papillary Serous tumor in a teenage girl: A Case Report

“…Omental cysts can affect people of all ages, but they are more common in children and adolescents. Pancreatic pseudo cysts, mesenteric cysts, urinary retention, bladder diverticulum, hydronephrosis, cystic lymphangiomas, choledochalcysts, splenic cysts, multicystic dysplastic kidney, gastrointestinal duplication cysts, and broad uterine tumour are all possible diagnoses [5] .…”

Ovarian mucinous and seromucinous neoplasms: problematic aspects and modern diagnostic approach

“…has recently reported the first sizeable series of these benign tumours. 110 Of 22 cases reported, the mean patient age was 62 (range = 32-83). The mean tumour size was 9 cm (0.7-30 cm) and both unilocular and multilocular examples were encountered; four of 22 cases included an adenofibromatous component.…”

“…107 Very rarely, an extra-ovarian seromucinous borderline tumour may arise in association with endometriosis. 24 In line with the reclassification of seromucinous carcinomas as variants of endometrioid carcinoma, it could be argued that seromucinous borderline tumours represent morphological variants of endometrioid borderline tumour, 110 particularly given the common association with endometriosis and shared molecular characteristics with other endometriosis-associated tumours. 105 However, the term 'seromucinous borderline tumour' is retained in the WHO 2020 Classification.…”

“…One of us (W.G.M.) has recently reported the first sizeable series of these benign tumours 110 . Of 22 cases reported, the mean patient age was 62 (range = 32–83).…”

“…The association of benign seromucinous tumours with endometriosis raises several additional points. First, it is probable that some of these tumours may, in fact, represent benign endometrioid cystadenomas/adenofibromas with ciliated and/or mucinous metaplasia 110 . It follows that the distinction between an endometriotic cyst with mucinous and/or ciliated metaplasia and a seromucinous cystadenoma may be subjective and arbitrary; in the presence of extensive endometrial‐type stroma, we recommend a diagnosis of endometriosis.…”