Ovarian reserve and response are associated with oocyte telomere DNA content not peripheral blood telomere DNA content

Kalmbach, Keri; Antunes, Danielle Mota Fontes; Kramer, Y.G.; McCulloh, David H.; Keefe, David L.

doi:10.1016/j.fertnstert.2015.07.616

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“…Nevertheless, similar findings were reported by Morin et al when comparing LTL and CCTL in four groups of patients differing in age and ovarian reserve (20). Likewise, it has also been reported that TL in human oocytes is not associated with the patient's age (26). Therefore, these data argue for the existence of a particular mechanism of coping with telomere attrition in the ovary, as well as for the hypothesis that decline in ovarian function might not go hand in hand with telomere biology in ovarian cells.…”

Section: Figuresupporting

confidence: 80%

Cumulus cells have longer telomeres than leukocytes in reproductive-age women

Lara-Molina¹,

Franasiak

Marín

et al. 2020

Fertility and Sterility

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To investigate whether telomere length (TL) in granulosa cells (GC) or cumulus cells (CC) correlates with TL in leukocytes (L). Design: Prospective noninterventional study. Setting: Private assisted reproductive technology center. Patient(s): Thirty-five egg donors were included in the study. Interventions(s): None. Main Outcome Measure(s): Average relative leukocyte telomere length (LTL), cumulus cell telomere length (CCTL), and granulosa cell telomere length (GCTL) measurements from each study subject. Result(s): Participants had a mean age of 25.43 AE 4.57 years, antim€ ullerian hormone level of 1.90 AE 0.92 ng/mL, antral follicle count of 23.29 AE 5.11, and the mean number of mature oocytes retrieved was 23.29 AE 9.13. No significant association between these variables and GCTL, CCTL, or LTL was found. In addition, no correlation was observed between TL measurements of L vs. CC, L vs. GC, or CC vs. GC. Interestingly, CCTL was significantly higher than LTL (1.54-fold), although no significant differences were found between GCTL vs. CCTL or GCTL vs. LTL. Conclusion(s): CC from mature follicles have significantly longer telomeres than L, suggesting that the follicular environment could possess different mechanisms to cope against telomere shortening compared with other somatic tissues. Furthermore, these data do not support the utility of telomere DNA measurement in L as an estimate of TL in follicular cells. (Fertil Steril Ò 2020;113:217-23. Ó2019 by American Society for Reproductive Medicine.) El resumen está disponible en Español al final del artículo.

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Section: Figuresupporting

confidence: 80%