Ovarian reserve and oocyte maturity in women with malignancy undergoing in vitro maturation treatment

Moria, Anwar; Das, Mausumi; Shehata, Fady; Holzer, Hananel; Son, Weon‐Young; Tulandi, Togas

doi:10.1016/j.fertnstert.2010.12.041

Cited by 36 publications

(22 citation statements)

References 14 publications

(15 reference statements)

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“…The majority of published studies regarding ovarian reserve have not demonstrated significant differences between patients with malignancy and their age-matched controls [18][19][20][21], although some authors have reported significantly lower AMH levels in patients with lymphoma [22] and lower AFC in women with cancer than in healthy controls [23]. Analyzing the ovarian reserve status was not the main goal of the current study but the observed data do not seem to reveal diminished ovarian reserve ( Table 1).…”

Section: Discussionmentioning

confidence: 64%

Ovarian response to controlled ovarian hyperstimulation in women with cancer is as expected according to an age-specific nomogram

Devesa

Martínez

Coroleu

et al. 2014

J Assist Reprod Genet

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Purpose To evaluate the ovarian response to controlled ovarian hyperstimulation (COH) in cancer patients according to an age-specific nomogram for the number of retrieved oocytes. Methods Retrospective observational study carried out in a University affiliated fertility clinic. Forty-eight patients with cancer underwent ovarian stimulation for oocyte cryopreservation. An age -specific nomogram for the number of retrieved oocytes was built with 1536 IVF cycles due to male factor exclusively, oocyte donation and age related fertility preservation. The number of oocytes retrieved in cancer patients was compared to the expected response according to the nomogram using the Z-score. Results The mean number of total retrieved oocytes in patients with cancer was 14.04±8.83. After applying the Z-score to compare the number of retrieved oocytes between women with cancer and the expected response according to the agespecific nomogram, we did not observe a statistically significant difference (Z-score 0.23; 95 % CI [−0.13-0.60]). Conclusion(s) According to our results, patients with cancer exhibit an ovarian response as expected by age. Despite the limitation of the sample size, the obtained results should encourage oncologists for early referral of women with cancer to fertility specialists.

show abstract

Section: Discussionmentioning

confidence: 64%

Ovarian response to controlled ovarian hyperstimulation in women with cancer is as expected according to an age-specific nomogram

Devesa

Martínez

Coroleu

et al. 2014

J Assist Reprod Genet

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show abstract

“…In general, breast cancer patients tended to need higher doses and longer administration of fsh 3 , to show reduced maximal levels of estradiol on betahuman chorionic gonadotropin administration day, and to have a reduced number of oocytes 6,9 . Those observations might be explained by the relatively older age of patients diagnosed with breast cancer (Quintero et al found a higher degree of poor response among breast cancer patients).…”

Section: Discussionmentioning

confidence: 97%

“…Moria et al 6 reported lower baseline levels of fsh for patients with hematologic malignancy, but similar levels of fsh in control subjects and in patients with breast cancer and other types of cancer. The younger age of patients with hematologic malignancies (mostly Hodgkin lymphoma) in all probability explains the statistical difference.…”

Section: Levin Md* and B Almog Md*mentioning

confidence: 89%

“…Das et al and Moria et al 2,6 used the afc to assess ovarian reserve. Both groups found no significant difference between cancer patients and control subjects.…”

Section: Levin Md* and B Almog Md*mentioning

confidence: 99%

“…Other studies, with significantly larger series of patients, reported no difference in quality or quantity or in the fertilization rates of oocytes for patients with cancers other than breast cancer. As in the case of the stimulation protocol, Moria et al found that significantly fewer oocytes were retrieved in breast cancer patients 6 . Their work used in vitro maturation, and so no stimulation protocol was given.…”

Section: Effect Of Cancer On Number and Quality And Quantity Of Oocytesmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Cancer on Ovarian Function in Patients Undergoing In Vitro Fertilization for Fertility Preservation: A Reappraisal

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2013

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Fertility Preservation

Jadoul¹,

Dolmans²,

Donnez³

2012

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Ovarian reserve and oocyte maturity in women with malignancy undergoing in vitro maturation treatment

Cited by 36 publications

References 14 publications

Ovarian response to controlled ovarian hyperstimulation in women with cancer is as expected according to an age-specific nomogram

Ovarian response to controlled ovarian hyperstimulation in women with cancer is as expected according to an age-specific nomogram

Effect of Cancer on Ovarian Function in Patients Undergoing In Vitro Fertilization for Fertility Preservation: A Reappraisal

Fertility Preservation

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