Ovarian refractoriness during lactation in women: Effect of gonadotropin stimulation

Zárate, Arturo; Canales, Elías S.; Soria, Jorge; Ruíz, Francisco; MacGregor, Carlos

doi:10.1016/0002-9378(72)90192-5

Cited by 84 publications

(16 citation statements)

References 5 publications

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“…On the contrary, our results support the view that pituitary gonadotropin secretion is not inhibited by suckling and is able to respond to LH-RH administration during puerperium despite the presence of hyperprolactinemia [Canales et al, 1974;Nakano et al, 1974]. Thus the most likely mechanism involved in the anovu latory state during puerperium is the ovarian refraction into gonadotropins [ZArate et al, 1972[ZArate et al, , 1974Rolland et al, 1975], because basal pituitary FSH and LH secretions are not inhibited after the 1st week post partum and suckling does not suppress gonadotropin release.…”

Section: Discussioncontrasting

confidence: 51%

Effect of Suckling on Serum Follicle-Stimulating Hormone and Luteinizing Hormone in Nursing Women

Soria¹,

Zárate²,

Canales³

et al. 1976

Neuroendocrinology

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Section: Discussioncontrasting

confidence: 51%

Effect of Suckling on Serum Follicle-Stimulating Hormone and Luteinizing Hormone in Nursing Women

Soria¹,

Zárate²,

Canales³

et al. 1976

Neuroendocrinology

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“…In addition, no changes in prolactin levels occur when gonadotrophins are elevated in postmenopausal women (McNeilly, Ormston and Hall, unpublished observations), after clomiphene in normal men (Thorner et al, 1974) (Zarate et al, 1972), or galactorrhoea (Thorner et al, 1974) (Thorner et al, 1974a), indicating removal of a peripheral block to steroidogenesis. Since Bromocriptine specifically affects only the secretion of prolactin, it would appear that elevated levels of prolactin inhibit steroidogenesis at the site of the ovary.…”

Section: Prolactin and The Menstrual Cyclementioning

confidence: 99%

Lactation and the physiology of prolactin secretion

McNeilly

1975

Postgraduate Medical Journal

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Summary Prolactin in man appears to form an essential part of the complex of hormones necessary for milk secretion and lactation. Levels of prolactin during pregnancy gradually increase towards term, and remain elevated for up to 6 weeks post partum. The lactogenic effects of prolactin appear to be blocked at the mammary gland by the elevated levels of fetoplacental steroids secreted during pregnancy. The immediate decline in steroid levels at delivery removes this block to prolactin and milk secretion ensues. The amenorrhoea associated with both puerperal lactation and galactorrhoea appears to reflect failure of cyclical discharge of gonadotrophins and anovulation. This appears to be due to peripheral inhibition of steroidogenesis by the elevated levels of prolactin associated with these situations. No consistent changes in circulating levels of prolactin occur during the menstrual cycle, but changes in prolactin levels within the follicular fluid of the developing ovarian follicle indicate a specific and permissive role of prolactin in steroidogenesis.

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“…Serial studies proved feasible in 15 women who did not breast-feed, nine women who fully breast-fed up to or beyond the sixth-week after delivery, and three women who breast-fed for only three weeks. All had normal pregnancies and vaginal delivery of term infants and had no hormone or other drug treatment apart from analgesics in labour and in the first week after delivery.…”

Section: Methodsmentioning

confidence: 99%