Ovarian preservation during the surgical treatment of early stage endometrial cancer: A nation-wide study conducted by the Korean Gynecologic Oncology Group

Lee, Taek Sang; Kim, Jae Weon; Kim, Tae Jin; Cho, Chi Heum; Ryu, Sang Young; Ryu, Hee Sug; Kim, Byoung Gie; Lee, Keun Ho; Kim, Yong Man; Kang, Soon‐Beom

doi:10.1016/j.ygyno.2009.06.041

Cited by 44 publications

(21 citation statements)

References 23 publications

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“…Thus, gynecological oncologists face a difficult choice in the management of young patients with endometrial cancer. Although a few reports have demonstrated the same survival rate of ovarian preservation in young women with endometrial cancer in the United States and Korea (7)(8)(9), the issue is highly controversial and requires further consideration.…”

mentioning

confidence: 99%

Safety of ovarian preservation in young patients with early-stage endometrial cancer: a retrospective study and meta-analysis

Sun

Chen

Yang

et al. 2013

Fertility and Sterility

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mentioning

confidence: 99%

Safety of ovarian preservation in young patients with early-stage endometrial cancer: a retrospective study and meta-analysis

Sun

Chen

Yang

et al. 2013

Fertility and Sterility

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“…A total of 107 patients were eligible for these criteria and finally included. In this study population, 10 patients who have already been reported in a recent study by the KGOG 14 were included. Table 1 shows the clinico-pathological characteristics of the 107 patients.…”

Section: Methodsmentioning

confidence: 99%

Premenopausal early-stage endometrial carcinoma patients with low CA-125 levels and low tumor grade may undergo ovary-saving surgery

et al. 2009

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Objective: The purpose of this study was to determine the possible predicting factors of coexisting adnexal malignancies, and to evaluate the safety of ovary-saving surgery for early-stage endometrial carcinoma in premenopausal patients. Methods: A retrospective review of 107 patients with endometrial carcinoma who underwent surgical treatment at our institution was conducted. All patients were younger than 50 years of age and premenopausal status. Statistical analysis was performed. Results: Of the 107 patients, 78 patients had stage I to II disease and both preoperative CA-125 levels were measured and tumor grades evaluated. On multivariate analysis, preoperative CA-125 levels (p=0.018) and preoperative tumor grade (p=0.029) were independent predicting factors of adnexal diseases. The risk of coexisting ovarian malignancy was 1.8% in patients with preoperative CA-125 levels less than or equal to 34.5 U/ml and preoperative tumor grade 1 or 2. The risk increases to 20% for low CA-125 and grade 3, 13.3% for high CA-125 and grade 1 or 2, and 100% for high CA-125 and grade 3. Between patients who underwent unilateral salpingo-oophorectomy and those who underwent bilateral salpingo-oophorectomy, there was no statistically significant difference in terms of BMI, preoperative CA-125 levels, FIGO stage, histology, tumor grade, lymphadenectomy, and adjuvant treatment. Conclusion: Ovary-saving surgery for premenopausal, early-stage endometrial cancer patients may be considered as a treatment option in those with low preoperative CA-125 and low tumor grade.

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“…In the case of grade 1, stage 1A endometrial carcinoma with macroscopic normal ovaries, the risk of occult ovarian tumour is about 1%. 35,36 The prognosis for young women with endometrial cancer is good (i.e. well-differentiated lesion with minimal or absent myometrial invasion), resulting in a favourable 5-year, disease-specific survival rate.…”

Section: Endometrial Cancermentioning

confidence: 99%

Fertility-preserving surgical procedures, techniques

Martinez

Poilblanc

Ferron

et al. 2012

Best Practice & Research Clinical Obstetrics & Gynaecol

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Ovarian preservation during the surgical treatment of early stage endometrial cancer: A nation-wide study conducted by the Korean Gynecologic Oncology Group

Cited by 44 publications

References 23 publications

Safety of ovarian preservation in young patients with early-stage endometrial cancer: a retrospective study and meta-analysis

Safety of ovarian preservation in young patients with early-stage endometrial cancer: a retrospective study and meta-analysis

Premenopausal early-stage endometrial carcinoma patients with low CA-125 levels and low tumor grade may undergo ovary-saving surgery

Fertility-preserving surgical procedures, techniques

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