Ovarian mucinous tumour with a focus of anaplastic carcinoma: A case report

Hayman, John; Östör, Andrew G.

doi:10.3109/00313028509084758

Cited by 20 publications

(11 citation statements)

References 4 publications

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“…Similar features were reported by Chen et al 9 and Nichols et al 11 To date, less than 30 cases of foci of anaplastic carcinoma within a mucinous carcinoma have been reported, and incidence in an adolescent is exceptional. 8,[10][11][12][13]15,16,[18][19][20][21] This case illustrates that, although rare, persistent abdominal pain in an adolescent female may represent an ovarian epithelial malignancy. The question arises as to whether to subject every adolescent with abdominal pain to a pelvic examination and/or ultrasound.…”

Section: Discussionmentioning

confidence: 98%

“…Results of CEA staining have been equivocal 8,13 and vimentin has been shown to be negative in some nodules, 8,13,15 while weakly positive in others. 8,11,[13][14][15][16] Little has been written about distinguishing anaplastic carcinoma from true sarcoma, possibly because the distinction has little if any prognostic significance. 1 Careful histological examination and immunohistochemical technique, however, can prove useful in making such distinctions.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anaplastic Carcinoma Arising in an Ovarian Mucinous Cystadenocarcinoma in a 17-Year-Old Female

Vella

Cracchiolo

Heller

2006

Journal of Pediatric and Adolescent Gynecology

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Anaplastic Carcinoma Arising in an Ovarian Mucinous Cystadenocarcinoma in a 17-Year-Old Female

Vella

Cracchiolo

Heller

2006

Journal of Pediatric and Adolescent Gynecology

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“…19 That publication highlighted their unfavorable prognosis and morphology, typically that of large cells with abundant eosinophilic cytoplasm. Subsequently, about 16 additional examples have been reported in the literature, [2][3][4][6][7][8]14,15,21,24,25 most as individual cases and we included 11 examples in a prior report on ovarian mucinous tumors. 20 In this new report, we wish to highlight the relatively favorable prognosis of the tumors, when stage Ia, based on those 11 and others accrued since.…”

mentioning

confidence: 99%

Anaplastic Carcinoma in Mucinous Ovarian Tumors

Provenza

Young

Prat

2008

American Journal of Surgical Pathology

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Several types of mural nodules may develop in the wall of mucinous tumors of the ovary. The histopathologic features and prognosis of foci/nodules of anaplastic carcinoma are not well known. Although they were first thought to carry an invariably unfavorable prognosis, recent data indicate that this does not necessarily apply to stage Ia tumors. Slides from 34 consultation cases of mucinous ovarian tumors with foci/nodules of anaplastic carcinoma were reviewed and classified on the basis of their morphologic features. Cytokeratin stains were done in selected cases. Staging, treatment, and follow-up information were obtained. The foci/nodules of anaplastic carcinoma were classified histologically into 3 groups: (a) rhabdoid (n=12) having a diffuse arrangement of cells with large, bright, eosinophilic cytoplasms, eccentric nuclei, and one or more prominent nucleoli; (b) sarcomatoid (n=10) characterized by a spindle cell proliferation, with atypical and vesicular nuclei often with herringbone pattern; and (c) pleomorphic (n=12) exhibiting overlapping features of the first 2 categories. International Federation of Gynecology and Obstetrics (FIGO) stage was available in 31 cases: 15 were stage Ia, 6 stage Ic, 2 stage II, 7 stage III, and 1 stage IV. Follow-up was obtained in 21 cases. Seven patients died of the disease after a median time of 8 months: 3 stage IC, 1 stage II, 1 stage III, 1 stage IV, and the other was unstaged. Ten patients were alive and clinically free of disease after a median follow-up of 5 years: they were all stage Ia. Three patients (2 stages III and 1 stage IV) were alive with disease at 3 years, 9 months, and 7 months. The other patient (stage Ia) died of an unrelated cause. Thus, only 1 patient with stage Ia disease died, and she died of causes other than ovarian cancer. The presence of foci/nodules of anaplastic carcinoma in unruptured stage I mucinous tumors of the ovary does not necessarily carry an adverse prognosis. These foci/nodules may exhibit rhabdoid, sarcomatoid (spindle cell), or pleomorphic features.

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“…Malignant transformation in a dermoid, although exceptional, has been reported in ovarian [2,3,4] and intracerebral sites [5], and also in a lumbosacral subcutaneous cyst [6], but not in a lumbar vertebra.…”

Section: Introductionmentioning

confidence: 99%