Ovarian mature cystic teratoma with malignant transformation: two case reports

Tehranian, Afsaneh; Ghahghaei-Nezamabadi, Akram; Seifollahi, Akram; Kasraei, Sara; Dehghani-Nejad, Hamideh; Maleki‐Hajiagha, Arezoo

doi:10.1186/s13256-020-02594-4

Cited by 18 publications

(25 citation statements)

References 13 publications

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“…GCTs rank the second most common ON with a total number of 115 cases (29.48%) [ 3 ], out of which mature cystic teratoma was the most common (108 (27.6%)) as illustrated in Figures 3 , 4 . These findings were consistent with the previous studies [ 2 , 17 , 18 ]. No case of mixed germ cell tumor, embryonal carcinoma, choriocarcinoma, or gonadoblastoma was found.…”

Section: Discussionsupporting

confidence: 94%

Histopathological Spectrum of Ovarian Neoplasms: A Single-Center Study

Batool¹,

Rathore²,

Jahangir³

et al. 2022

Cureus

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Section: Discussionsupporting

confidence: 94%

Histopathological Spectrum of Ovarian Neoplasms: A Single-Center Study

Batool¹,

Rathore²,

Jahangir³

et al. 2022

Cureus

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“…14 The diagnostic value of CT and MRI examinations are essential when identifying malignant manifestations, such as necrosis, nodules, cyst wall growth, invasion of surrounding structures, or pelvic and abdominal metastases. 4,20 Unfortunately, MRI or CT scan was not performed in this case.…”

Section: Discussionmentioning

confidence: 97%

A rare case of squamous cell carcinoma transformation in a mature cystic teratoma of the ovary

Sibarani,

Permata,

Martiana

et al. 2023

SAGE Open Medical Case Reports

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Mature cystic teratoma of the ovary is the most common ovarian neoplasm (10%–20%). These tumors are generally benign but may undergo malignant transformation, 80% of which is squamous cell carcinoma, in postmenopausal women (1%–2%). Due to nonspecific findings, the preoperative diagnosis is challenging; most patients are detected at an advanced stage and have poor outcomes. A 40-year-old female, P2A0, complained of worsening lower abdominal pain and palpable abdominal mass. She had not been having menstrual periods for almost 4 months. For the last 3 months, she had asthenia, anorexia, and lost 10 kg. Abdominal examination was notable for an immobile, well-defined cystic mass measuring 12 × 8 × 8 cm with an irregular surface in the lower abdomen. Its overlying skin appeared reddish. A bimanual examination confirmed the adnexal origin of the cystic mass. Laboratory examination was notable for leukocytosis, thrombocytosis, increased neutrophil-to-lymphocyte ratio, and reduced absolute lymphocyte count. There was an increase in her cancer antigen 125. An abdominal ultrasonography examination showed bilateral mature cystic teratoma. A bilateral salpingo-oophorectomy was performed. A postoperative diagnosis of bilateral dermoid ovarian cysts was then established. The patient histopathology examination concluded squamous cell carcinoma (malignant transformation from benign cystic teratoma) in bilateral ovaries. The patient was referred to a gynecology oncology center for further examination and management. However, she missed the appointment for an unknown reason. The patient passed away 4 months after surgery. Clinicians should be aware of the possibility of malignant transformation of teratoma if a tumor has been present for a long time, its diameter is greater than 10 cm, there is a thickening of the cyst wall with papillary growth, there is an increase in tumor markers, and the patient is postmenopause. Malignant transformation of mature cystic teratoma remains a diagnostic and therapeutic puzzle and the prognosis is poor despite extensive initial surgery and optimal debulking.

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“…Tehranian A, et al en el año 2021, describieron dos casos de teratoma inmaduro, el caso número 1, a pesar de la etapa temprana (Ia) de las enfermedades y de buen pronóstico, los niveles séricos de CA125 y CEA estaban por encima del rango normal, mientras que en el caso número 2, que se encontraba en el estadio IIIc de la enfermedad, los niveles séricos de CEA, CA19-9 y HE4 eran normales, y solo CA125 y ROMA estaban ligeramente elevados por encima del rango normal. Por lo que los marcadores tumorales solo sirven para el seguimiento y pronóstico, pero no es directamente proporcional al estadio o tamaño del tumor (27). Referente al caso presentado en este artículo, se trató de una mujer joven de 31 años de edad con Carrera de Medicina.…”

Section: Discussionunclassified

Teratoma gigante de ovario. Presentación de caso clínico

et al. 2023

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El teratoma gigante de ovario, es una neoplasia que puede ser benigna o maligna de acuerdo a su tipo histológico. Estos tumores se van a clasificar en maduros o benigno e inmaduros o malignos, y de esto, va a depender su tratamiento y también su pronóstico. El objetivo de este trabajo es presentar un caso clínico de teratoma gigante de ovario, su diagnóstico y tratamiento. Materiales y métodos: se realizó un estudio cualitativo, descriptivo; presentación de caso clínico de un teratoma gigante de ovario. Se describen aspectos relevantes de esta neoplasia y la importancia del diagnóstico oportuno. Se obtuvo autorización del departamento de docencia e investigación del Hospital Alfredo G Paulson, permitiendo la revisión de historia clínica e imágenes, para la publicación del presente caso. Resultados: se presentó el caso de una paciente femenina de 31 años de edad, que presenta gran masa palpable a nivel abdominal, acompañado de dolor en fosa iliaca izquierda, que se irradia a miembro inferior del mismo lado. Se brinda tratamiento quirúrgico realizándose histerectomía abdominal total, salpingooforectomía izquierda, resección en cuña de ovario derecho, omentectomia y adhesiolisis; se obtiene un tumor anexial izquierdo de 26 x 20 x 15 cm, cuyo diagnóstico histopatológico reporto: teratoma inmaduro grado 2 en ovario izquierdo. Conclusiones: el teratoma de ovario debe ser diagnosticado precozmente, pese a sus signos y síntomas inespecíficos; si se trata de un teratoma maduro en jóvenes o adolescentes se recomienda tratamiento quirúrgico conservador con cistectomía y seguimiento periódico anual no obstante, si se trata de un teratoma inmaduro de acuerdo a su estadio, se procederá a acompañar el tratamiento quirúrgico de salpingo ooforectomía total con quimioterapia adyuvante. Por lo general el pronóstico del teratoma es bueno, ya que el 80 % de los casos son de origen benigno, sin embargo, existe un pequeño porcentaje de riesgo de trasformación a malignos, por lo que es una patología de sumo cuidado, control e interés.

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Ovarian mature cystic teratoma with malignant transformation: two case reports

Cited by 18 publications

References 13 publications

Histopathological Spectrum of Ovarian Neoplasms: A Single-Center Study

Histopathological Spectrum of Ovarian Neoplasms: A Single-Center Study

A rare case of squamous cell carcinoma transformation in a mature cystic teratoma of the ovary

Teratoma gigante de ovario. Presentación de caso clínico

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