Ovarian Mature Cystic Teratoma is an Independent Risk Factor for the Premature Rupture of Membranes in Pregnancy: A Single-Center Retrospective Study

Abstract

Background: Ovarian mature cystic teratomas (MCTs) are the most common tumors in pregnant women. The premature rupture of membranes (PROM) is a typical complication of pregnancy; however, the relationship between MCT and PROM is unknown. Therefore, we aimed to determine whether MCT is associated with the occurrence of PROM during pregnancy. Methods: The data of patients with adnexal masses during pregnancy between January 2017 and August 2021 were retrospectively analyzed. Ovarian cystectomy was performed during cesarean delivery or after vaginal delivery. Univariate and multivariate logistic regression models were used for statistical analysis. Results: A total of 234 patients with histopathological results were included. Among these patients, 21 occurred PROM during pregnancy, of which 11 were diagnosed with MCT. Compared with other subtypes, MCT (p=0.025) showed a stronger correlation with PROM and was an independent risk factor for PROM (odds ratio [OR], 2.811; 95% confidence interval [CI], 1.096-7.215; p=0.032). Furthermore, we found that MCT with a diameter >5 cm (p=0.0037) was more likely to promote the development of PROM than those that with a diameter <5 cm. Conclusion: MCT was an independent risk factor for PROM during pregnancy. Positive actions and preventative clinical treatments should be fully taken into consideration by clinicians for pregnant women with MCTs, especially those ≥5 cm in diameter, to reduce the clinical complications related to MCT-associated PROM.

Editorial: Diagnosis and treatment of gynecologic malignancies during pregnancy

“…There is evidence that combined PCDHGB7 methylation detection may help in screening for cervical tumors during pregnancy ( 4 ). Malignant ovarian tumors were reported in 0.85 per 10,000 deliveries, ranging from 0.44 to 1.71 per 10,000 pregnancies ( 5 ), with mature cystic teratoma being the most common benign ovarian tumor in patients with adnexal masses; this was an independent risk factor for premature rupture of membranes ( 6 ). We further explored the risk factors for gynecological tumors and the clinical prognostic benefits of adjuvant chemotherapy and investigated the impact of malignant tumors on the outcomes of assisted reproductive pregnancy.…”