Ovarian masses during adolescence: clinical, ultrasonographic and pathologic findings, serum tumor markers and endocrinological profile

Abstract

This retrospective study was undertaken to assess the epidemiological and clinical features, laboratory findings, preoperative work-up, surgical treatment and pathologic findings in adolescents with ovarian cysts. All adolescents who were referred to our institution and had been operated on because of a diagnosed ovarian mass, from January 1997 to June 2003, were included in this study. Forty-four cases of women with an ovarian mass were retrospectively analyzed. These patients, aged between 12 and 21 years, had 47 ovarian masses (three patients had bilateral lesions), of which 49% were non-neoplastic and 51% were neoplastic. Of the neoplastic lesions, 62.5% were germ cell tumors, 20.8% were epithelial and 16.7% were sex cord-stromal tumors. Of the neoplastic tumors, 95.8% were benign while 4.2% were malignant. Procedures included 30 operative laparoscopies (68.20%) and 14 exploratory laparotomies (31.8%). Simple excision of the ovarian cyst was performed in 39 cases (88.6%). According to our study, most of the adolescents with an ovarian cyst underwent an operation because of a neoplastic lesion. The majority of ovarian tumors occurring in adolescents are non-epithelial in origin, and germ cell tumors are the most common histological type. Ultrasound examination is one of the most important diagnostic tools. Preoperative diagnostic approach of these patients should always include careful history taking, physical examination, imaging and evaluation of serum assays. Gynecologists who care for young girls must be familiar with the differential diagnosis of ovarian masses whose surgical treatment should be conservative when appropriate, so that hormonal status and future fertility are not compromised in this group of patients.

Adnexal masses in adolescent girls with pelvic pain: Report on 63 cases

“…Although the series of 47 cases previously reported by Deligeoroglou et al showed 49% were functional, 51% were neoplastic and 4.2% were malignant, we did not detect malign lesions in our series [10]. Therefore, we can argue that these findings probably represent an appropriate preoperative evaluation by ultrasonography and serum tumor markers whenever necessary.…”

Value of the Platelet to Lymphocyte Ratio in the Diagnosis of Ovarian Neoplasms in Adolescents

“…The malignant cases constitute a very small number of the adolescent patients (Hassan et al, 1999). The most common presenting symptom is abdominal pain in adolescents with adnexal masses (Deligeoroglou et al, 2004). A smaller part of patients has no symptoms or complains of having irregular menstrual cycles.…”

“…Lui et al (2013) reported that 13.6% of ovarian masses were malignant or borderline in children and adolescents aged between 2 to 18 years. Deligeoroglou et al (2004) evaluated 44 patients with ovarian masses, aged between 12-21 years, 49% of them were non neoplastic and 51% were neoplastic. Of the neoplastic tumors, 95.8% were benign while 4.2% were malignant in his study.…”

“…Functional cysts, ovarian torsion, and benign neoplasms are the most common ovarian masses in young adolescents (Liu et al, 2013). Ovarian neoplasms are estimated to occur at a rate of approximately 2.6 in 100,000 girls per year (Ki et al, 2013) and malignant ovarian tumors in children and adolescents are rare, accounting for 0.9% of all malignancies (Deligeoroglou et al, 2004). Most ovarian masses are non-neoplastic or benign neoplasms; fewer than 10 percent of ovarian malignancies occur in this age Gulnur Ozaksit, Aytekin Tokmak*, Hatice Kalkan, Huseyin Yesilyurt group (Zhang et al, 2014).…”

Hasi cysták és cystosus képletek differenciáldiagnózisa gyermekkorban

“…A közleményünkben ismertetett gyermekekben benignus elváltozásokat diagnosztizál-tunk. A malignus ovariumtumorok előfordulása gyermekkorban ritka, különösen ötéves kor alatt [9]. Az ösz-szes malignus gyermekkori tumorok mindössze 0,9%-át teszik ki [10].…”