Ovarian Leydig Cells (OLC): About their Heterotopia or Eutopia

Two Rare Cases of Paratubal Leydig Cell Nodules: Clinical Relevance and Debated Terminology of a Noteworthy Incidentaloma

“…Although these nodules are incidental, small, and benign, they are relevant to the general surgical pathologist by potentially posing a diagnostic challenge if not familiar with this rare finding. Like the current cases, Leydig cell nests or nodules may be found in the mesosalpinx or in the mid portion of the fallopian tube (1,3,4,6,12), or they may be located in the fimbriated end of the fallopian tube (5,(7)(8)(9)(10)12). Reinke crystals are an inconsistent finding in Leydig cell nodules, and several authors specifically reported not being able to find them in their cases (3,4,(8)(9)(10), whereas others were able to document them (1,5-7).…”

“…Based on Sternberg's description of extratesticular testosterone-producing Leydig cells, which he designated OHCs, these nests have been referred to as hilus cells rest (3), hilus cell hyperplasia (4,5), or hilus cell heterotopia (6)(7)(8)(9)(10). The use of the term heterotopia for nests or nodules found at extraovarian sites led to academic debate and study as to whether the term eutopia is more appropriate to use than heterotopia (1,6,7,(11)(12)(13). Case series of microscopic sex cord proliferations with sertoliform histology (14) and histologic features other than sertoliform or Leydig cell patterns (15) have also been described.…”

“…In 2017 Carrasco-Juan et al (1,12). began using the term ovarian Leydig cells (OLCs) to more accurately reflect the morphology and function of the cells forming these nodules.…”

“…began using the term ovarian Leydig cells (OLCs) to more accurately reflect the morphology and function of the cells forming these nodules. OHC/OLC nests may be found associated with nerve fibers, nerve ganglia, or blood vessels (1,6,9,11,12). Because of these associations and the epithelioid morphology of the cells, these nodules may mimic perineural or intraneural tumor invasion in specimens resected for malignant neoplasms, and could potentially lead to erroneous upstaging of a malignant tumor.…”

Features of treatment rare forms of stromal cell ovarian tumors

“…Опухоль из клеток Лейдига ТОМ 11 / VOL. 11 1' 2021 Тазовая хирургия и онкология Pelvic Surgery and Oncology о р и г и н а л ь н о е и с с л е д о в а н и е обычно поражает яичник с одной стороны и достигает в среднем около 5 см в диаметре, что позволяет проводить хирургическое лечение новообразования [10,[18][19][20]. Стромальная лютеома -другое солидное стромально-клеточное новообразование, относящееся к липидно-клеточным опухолям.…”