Ovarian Leydig cell hyperplasia as a rare cause of hair loss in a postmenopausal female patient: a case report and diagnostic approach toward postmenopausal hyperandrogenism

Koeneman, Margot M.; Heiligers-Duckers, Connie; Velde, Robert van der; Wouda, S.; Rooij, M.J.M. de; Janssen, Marcel J.W.; Boskamp, Dieuwke

doi:10.1016/j.ejogrb.2016.01.024

Cited by 2 publications

(4 citation statements)

References 3 publications

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“…Our first case provides a classic example of the typical LCH presentation with symptoms and laboratory findings consistent with excess androgen production. Some level of hyperandrogenism can be considered a normal physiologic response to a menopause-induced drop in estrogen with a lagging concomitant decline in androgen production [ 1 ]. Symptomatic patients should undergo an evaluation of the adrenal glands, pituitary gland, and ovaries.…”

Section: Discussionmentioning

confidence: 99%

“…Symptomatic patients should undergo an evaluation of the adrenal glands, pituitary gland, and ovaries. The differential is broad for these patients, including androgen-producing tumors of the ovary or adrenals, Cushing's syndrome, obesity, congenital adrenal hyperplasia, and iatrogenic causes [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…Evaluation of symptomatic patients often starts with quantification of androgen levels and testing for hypercortisolism. This is traditionally followed by imaging of the adrenal glands, pituitary gland, and ovaries, with additional tests as warranted based on results [ 1 ]. The extent of testing for postmenopausal women with symptoms of hyperandrogenism has been contested by some authors.…”

Section: Discussionmentioning

confidence: 99%

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Varying Phenotypes of Leydig Cell Hyperplasia of the Ovary: Two Case Reports

Caulkins

Ricciuti

Desouki

et al. 2023

Case Reports in Obstetrics and Gynecology

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Leydig cell hyperplasia (LCH) is a rare cause of hyperandrogenism that has been described only in case reports. The cases presented herein contrast the traditional presentation of LCH with an affected asymptomatic individual. The first case involves a 74-year-old woman presenting with symptomatic hyperandrogenism, whose symptoms resolved after bilateral salpingo-oophorectomy (BSO). The second patient presented with postmenopausal bleeding and an abdominal mass. Following total abdominal hysterectomy (TAH) and BSO, pathology showed ovarian LCH with concomitant endometrial cancer. The diagnosis of LCH is complex and requires careful investigation of many differential diagnoses. Incidentally discovered LCH may shed light on evolution and disease progression. Cases of LCH found in the setting of endometrial pathology may have implications on other states of testosterone excess.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Varying Phenotypes of Leydig Cell Hyperplasia of the Ovary: Two Case Reports

Caulkins

Ricciuti

Desouki

et al. 2023

Case Reports in Obstetrics and Gynecology

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“…4 Obesity, androgen producing adrenal tumors, congenital adrenal hyperplasia, and Cushing's syndrome are some of the disease entities that might also result in female hyperandrogenism. 5 Although virilization is the key feature of suspecting the presence of SLCTs, other symptoms such as hyperestrogenism or abdominal pain and distention due to the sheer size of the mass also occur. 6 In the study involving 11 SLCTs from a single institution, all of the cases presented with an adnexal mass varying from 5cm to 20cm.…”

Section: Discussionmentioning

confidence: 99%

Incidental finding of a Sertoli-Leydig cell tumor in a postmenopausal woman with complex endometrial hyperplasia

Kim

Lee

Chung

2018

Int J Reprod Contracept Obstet Gynecol

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Sertoli-Leydig cell tumors (SLCTs) arise from the non-germ cell component of the ovary and typically present in young women with evidence of hyperandrogenism such as precocious puberty, amenorrhea, hirsutism and virilization. It is very rare accounting for less than 0.2% of all ovarian tumors, and because of the rarity, no standardized treatment approach has reached a consensus. The prognosis is generally good with complete reversion of symptoms after surgery, although some cases have been reported to be malignant. Recently the need for DICER1 mutations testing in paediatric patients has been emphasized for the surveillance of possible synchronous tumors and affected family members. Authors present here a case of Sertoli-Leydig cell tumor incidentally found while performing a hysterectomy with bilateral salpingo-oophorectomy in a postmenopausal woman with endometrial hyperplasia that caused intractable vaginal bleeding.

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Ovarian Leydig cell hyperplasia as a rare cause of hair loss in a postmenopausal female patient: a case report and diagnostic approach toward postmenopausal hyperandrogenism

Cited by 2 publications

References 3 publications

Varying Phenotypes of Leydig Cell Hyperplasia of the Ovary: Two Case Reports

Varying Phenotypes of Leydig Cell Hyperplasia of the Ovary: Two Case Reports

Incidental finding of a Sertoli-Leydig cell tumor in a postmenopausal woman with complex endometrial hyperplasia

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