Ovarian Influence on the Content of Norepinephrine Transmitter in Guinea Pig and Rat Uterus

Falck, B.; Gårdmark, S.; Nybell, G.; Owman, Ch.; Rosengren, E.; Sjöberg, Nils‐Otto

doi:10.1210/endo-94-5-1475

Cited by 30 publications

(11 citation statements)

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“…Our results showing no variations of the autonomic innervation between dioestrus and oestms, are in marked contrast with previous data (Adham & Schenk, 1969), but agree with biochemical studies (Falck et al, 1974). Accordingly, the uterus of prepubertal animals exhibited an adult pattern of innervation.…”

Section: Discussionsupporting

confidence: 76%

“…innervation of the rat uterine musculature (Sj6berg, 1967;Adham & Schenk, 1969;Kanerva e~ al., 1972;Hervonen et aI., 1973;Falck et al, 1974;Hollingsworth, 1974;Garfield, 1986;Mustafa e~ al., 1987) may be explained on technical grounds. Except for Garfield (1986), all these authors used formaldehyde-induced fluorescence methods for demonstrating monoamines.…”

Section: Discussionmentioning

confidence: 99%

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Noradrenergic and acetylcholinesterase-positive nerve fibres of the uterus in sexually immature and cycling rats

Melo

Machado

1993

Histochem J

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The distribution and density of the noradrenergic and acetylcholinesterase-positive nerve fibres were histochemically studied in different uterine regions of prepubertal and cycling rats in dioestrus and oestrus. Besides the rich and double innervation of blood vessels, both types of nerve fibre were found in the myometrium and cervical musculature. The non-vascular noradrenergic network looked denser at the tubal end of the horns and at the cervix, whereas the acetylcholinesterase-positive innervation was poor at the tubal end, increasing toward the cervix. Contrasting with the middle third of the uterine horn, at the tubal end, the myometrial longitudinal layer was much more innervated than the circular one, especially by the noradrenergic nerve fibres. The prepubertal rats presented an adult pattern of uterine autonomic innervation. In the cycling animals, this innervation was nearly the same during oestrus and dioestrus regarding both the density of nerve fibres and intensity of the histochemical reactions.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Noradrenergic and acetylcholinesterase-positive nerve fibres of the uterus in sexually immature and cycling rats

Melo

Machado

1993

Histochem J

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“…The adrenergic innervation of the uterus consists mainly of short postganglionic ter minals, in contrast to the oviduct [1][2][3]. The difference in the function of short postgan glionic terminals in comparison with long terminals may also explain the greater inacti vation of 'H-NA by uptake in the fallopian tubes.…”

Section: Discussionmentioning

confidence: 99%

“…Functionally, these short adrenergic nerves are different from the or dinary long adrenergic neurons [1,2], The adrenergic innervation of the uterine artery and oviduct consists mainly of long postgan glionic terminals and only to a lesser extent of short terminals, in contrast to the uterine adrenergic terminals, which are mainly short [3][4][5][6], At the beginning of pregnancy the adren ergic transmitter concentration increases in many species but decreases toward the end of pregnancy [3,4,7]. The uterine tissue of the pregnant patients has also lower uptake capacity for 3H-noradrenaline (3H-NA) than the corresponding tissue of nonpregnant women [8].…”

Section: Introductionmentioning

confidence: 99%

“…The uterine tissue of the pregnant patients has also lower uptake capacity for 3H-noradrenaline (3H-NA) than the corresponding tissue of nonpregnant women [8]. The neuronal levels of NA in the uterus can be elevated by the treatment of nonpregnant animals with oestrogens [2], 17(3-Oestradiol was also able to decrease the uptake of 3H-NA in the myometrium in vi tro [9]. These findings suggest that ovarian and placental steroids might exert some con trol over the adrenergic mechanisms in the uterus both in pregnant and nonpregnant subjects.…”

Section: Introductionmentioning

confidence: 99%

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Adrenoceptor Function in Female Genital Tract

Saarikoski¹

1988

Gynecol Obstet Invest

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The function of adrenoceptors in the female genital tract was tested estimating the uptake of ³H-noradrenaline (³H-NA) in vitro in oviductal, uterine arterial and myome-trial tissue samples obtained from 74 women. The highest ³H-NA value, 64 ± 5 ng/g, was in the oviduct (p < 0.001 vs. uterine artery and myometrium). The uterine isthmus showed some higher uptake capacity for ³H-NA than did the uterine fundus: 24 ± 2 vs. 20 ± 1 ng/g, respectively (p < 0.05). No difference was found between the 3H-NA values for the proliferative and the secretory phase in tissues examined. High concentrations of oestradiol and progesterone effectively inhibited the ³H-NA uptake (p < 0.05–0.001). Inhibition was greatest in the oviduct and lowest in the uterine fundus and weaker at the lower concentrations of oestradiol and progesterone.

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The autonomic innervation of the interstitial gland of the rat ovary during pregnancy

Lawrence

Burden

1976

Am. J. Anat.

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The autonomic innervation of the interstitial gland of the rat ovary was studied on days 4, 6, 10, 14 and 18 of pregnancy with the acetylcholinesterase procedure, the Falck-Hillarp technique and electron microscopy after 5-hydroxydopamine treatment. Acetylcholinesterase-positive nerves were present as perivascular plexuses at all stages studied. Adrenergic nerves were present in the interstitial gland in all stages studied. The number and intensity of interstitial fluorescent adrenergic nerves increased as pregnancy progressed. Measurement of norepinephrine with the fluorometric procedure showed a highly significant (p less than 0.05) increase in the neurotransmitter in the ovary on days 14 and 18 as compared to day 4. Fine-structural studies after administration of the false transmitter, 5-hydroxydopamine, showed that the innervation of the steroidogenic cells of the interstitial gland is adrenergic.

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Ovarian Influence on the Content of Norepinephrine Transmitter in Guinea Pig and Rat Uterus

Cited by 30 publications

References 0 publications

Noradrenergic and acetylcholinesterase-positive nerve fibres of the uterus in sexually immature and cycling rats

Noradrenergic and acetylcholinesterase-positive nerve fibres of the uterus in sexually immature and cycling rats

Adrenoceptor Function in Female Genital Tract

The autonomic innervation of the interstitial gland of the rat ovary during pregnancy

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