Ovarian influence on adrenal androgen secretion in polycystic ovary syndrome

Fruzzetti, Franca; Lorenzo, Daniele De; Ricci, Cabiria; Teti, G

doi:10.1016/s0015-0282(16)57474-3

Cited by 21 publications

(10 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adrenal androgen secretion is not controlled solely by ACTH, an extra-adrenal mechanism other than ACTH is most probably involved additionally [14]. An ovarian messenger was suggested to mediate the crosstalk between adrenals and ovaries [15,16]. Suppression of the ovarian activity with GnRH agonist decreases DHEAS, but the messenger regulating this cross-talk between the ovaries and adrenal glands is unknown [17,18].…”

Section: Discussionmentioning

confidence: 99%

“…We only included patients aged between 16 [2] when at least two of the following criteria were present: oligomenorrhea-amenorrhea (menstrual dysfunction with a duration of more than six cycles and with a length of more than 35 days), clinical or biochemical signs of hyperandrogenism and the presence of polycystic ovaries (PCO) on transabdominal, transvaginal or transrectal ultrasonography (the presence of an ovary with 12 or more follicles measuring 2-9 mm in diameter). Clinical hyperandrogenism was defined as the presence of a Ferriman-Gallwey score 48.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

High DHEAS/free testosterone ratio is related to better metabolic parameters in women with PCOS

Güdücü

Kutay

Görmüş

et al. 2015

Gynecological Endocrinology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

High DHEAS/free testosterone ratio is related to better metabolic parameters in women with PCOS

Güdücü

Kutay

Görmüş

et al. 2015

Gynecological Endocrinology

View full text Add to dashboard Cite

show abstract

“…The exact etiology of adrenal androgen excess is not known. Increased adrenocorticotropic hormone (ACTH) production, increased adrenal sensitivity to ACTH, altered steroidogenic enzyme activity (17–20 lyase, 3-beta-hydroxysteroid dehydrogenase activity), and an overproduction of androgens in response to hyperprolactinemia have all been implicated as potential mechanisms [32]. …”

Section: Discussionmentioning

confidence: 99%

“…The induction of hypoestrogenism with gonadotropin-releasing hormone agonist reduces DHEAS levels. On the other hand, some of these metabolic characteristics may have a genetic background [32]. …”

Section: Discussionmentioning

confidence: 99%

Association between Hypoadiponectinemia and Low Serum Concentrations of Calcium and Vitamin D in Women with Polycystic Ovary Syndrome

et al. 2012

View full text Add to dashboard Cite

Objective. To investigate the possible association of calcium and vitamin D deficiency with hypoadiponectinemia in women with PCOS. Subjects and Methods. In this case-control study, 103 PCOS cases and 103 controls included. The concentrations of calcium, 25-OH-vitamin D (25OHD), adiponectin, insulin, glucose, total cholesterol, HDL-cholesterol, triglyceride (TG), and androgens were measured in fasting blood samples. Results. Adiponectin (8.4 ± 2.7 ng/mL versus 13.6 ± 5 ng/mL in control group, P : 0.00), calcium (2 ± 0.1 mmol/L versus 2.55 ± 0.17 mmol/L in controls, P : 0.00), and 25-OH-Vit D (30 ± 2.99 nmol/L versus 43.7 ± 5.2 nmol/L in control group, P : 0.00) levels were decreased in women with PCOS. Subjects with PCOS had higher concentrations of TG (1.4 ± 0.77 mmol/L versus 1.18 ± 0.75 mmol/L in control group, P : 0.019) and dehydroepiandrosterone sulfate (DHEA-S) (10.7 ± 11 mmol/L versus 9.7 ± 10.4, P : 0.02 in control group). There were significant correlations between adiponectin concentrations with calcium (r : 0.78, P : 0.00) and 25OHD levels (r : 0.82, P : 0.00). The association of hypoadiponectinemia and PCOS was not significant considering 25OHD as a confounding factor. Conclusion. The present findings indicate that the association of hypoadiponectinemia with PCOS is dependent on vitamin D. A possible beneficiary effect of vitamin D on the metabolic parameters in PCOS may be suggested.

show abstract

“…18,19 Con versely, there is data to suggest that in PCOS, the ovary plays a role in promoting excess adrenal an drogen production. [20][21][22][23][24] Therefore, in PCOS, the ovary and the adrenal may be capable of influenc ing each other in a bidirectional fashion aside from the traditional modulation exerted on either pe ripheral gland by the hypothalamus and the pitu itary.…”

mentioning

confidence: 99%

Adrenal Involvement in Polycystic Ovary Syndrome

González

1997

Semin Reprod Med

View full text Add to dashboard Cite

The etiology of hyperandrogenic chronic anovulation is heterogeneous and relatively unknown in the majority of cases. Affected individuals in this latter segment are considered to have polycystic ovary syndrome (PCOS) of which 50 to 60% exhibit androgen excess of adrenal origin. An understanding of normal adrenal function provides insight into the factors that contribute to adrenal androgen excess in PCOS. Since pituitary ACTH secretion promotes developmental growth and overall steroidogenic efficiency within the adrenal cortex, it is probable that these actions of ACTH along with the adrenal's unique centripetal circulation play a major role in the induction of adrenarche. This latter phenomenon is characterized by alterations in adrenocortical morphology and steroidogenic enzyme activities culminating in increases in adrenal androgens to normal circulating adult levels. Thus, it is not surprising that adrenal dynamic testing has revealed increased 17,20 lyase activity or adrenal androgen hyper-responsiveness to ACTH as the two abnormalities leading to adrenal androgen excess in PCOS. Whereas 17,20 lyase hyperactivity diagnosed by defined criteria in response to pharmacological ACTH may be an intrinsic genetic defect, increases in 17,20 lyase activity and adrenal androgen hyper-responsiveness to ACTH in response to physiological ACTH may be promoted by the functional elevation of estrogen of ovarian origin in PCOS. The latest in vitro data suggest the estrogen may elicit its effect on the adrenal cortex through a receptor mediated mechanism. Therefore, the currently available data indicate that adrenal androgen excess in PCOS is also heterogeneous in etiology.

show abstract

Ovarian influence on adrenal androgen secretion in polycystic ovary syndrome

Cited by 21 publications

References 24 publications

High DHEAS/free testosterone ratio is related to better metabolic parameters in women with PCOS

High DHEAS/free testosterone ratio is related to better metabolic parameters in women with PCOS

Association between Hypoadiponectinemia and Low Serum Concentrations of Calcium and Vitamin D in Women with Polycystic Ovary Syndrome

Adrenal Involvement in Polycystic Ovary Syndrome

Contact Info

Product

Resources

About