Ovarian function in adult rats treated with antithymocyte serum

Bukovský, Antonín; Presl, J; Krabec, Z; Bednarík, T

doi:10.1007/bf02124112

Cited by 28 publications

(11 citation statements)

References 4 publications

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“…This study implicates TNFα as a critical regulator of luteal regression. These results are supported indirectly by an earlier study in which anti-thymocyte antiserum was injected in rats to inhibit immune function [68]. Similar to the TNFRI -/- mice these rats failed to progress past the diestrous phase.…”

Section: Mutant Mice Models With Luteal Regression Defects/anomaliessupporting

confidence: 57%

Mutant mouse models and their contribution to our knowledge of corpus luteum development, function and regression

Henkes

Davis

Rueda

2003

Reprod Biol Endocrinol

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The corpus luteum is a unique organ, which is transitory in nature. The development, maintenance and regression of the corpus luteum are regulated by endocrine, paracrine and autocrine signaling events. Defining the specific mediators of luteal development, maintenance and regression has been difficult and often perplexing due to the complexity that stems from the variety of cell types that make up the luteal tissue. Moreover, some regulators may serve dual functions as a luteotropic and luteolytic agent depending on the temporal and spatial environment in which they are expressed. As a result, some confusion is present in the interpretation of in vitro and in vivo studies. More recently investigators have utilized mutant mouse models to define the functional significance of specific gene products. The goal of this mini-review is to identify and discuss mutant mouse models that have luteal anomalies, which may provide some clues as to the significance of specific regulators of corpus luteum function.

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Section: Mutant Mice Models With Luteal Regression Defects/anomaliessupporting

confidence: 57%

Mutant mouse models and their contribution to our knowledge of corpus luteum development, function and regression

Henkes

Davis

Rueda

2003

Reprod Biol Endocrinol

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“…Leukocyte recruitment and activation within the ovary are thought to play important roles in follicular atresia, ovulation, and luteal function [1-6]. Consequently, many studies concerning ovarian function within the past several years have focused on characterizing leukocyte populations within the ovary, understanding further the importance of leukocyte-ovarian cell interactions, and more recently, discerning the mechanisms of ovarian leukocyte recruitment.…”

Section: Introductionmentioning

confidence: 99%

Chemokines in the corpus luteum: Implications of leukocyte chemotaxis

Townson

Liptak

2003

Reprod Biol Endocrinol

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Chemokines are small molecular weight peptides responsible for adhesion, activation, and recruitment of leukocytes into tissues. Leukocytes are thought to influence follicular atresia, ovulation, and luteal function. Many studies in recent years have focused attention on the characterization of leukocyte populations within the ovary, the importance of leukocyte-ovarian cell interactions, and more recently, the mechanisms of ovarian leukocyte recruitment. Information about the role of chemokines and leukocyte trafficking (chemotaxis) during ovarian function is important to understanding paracrine-autocrine relationships shared between reproductive and immune systems. Recent advances regarding chemokine expression and leukocyte accumulation within the ovulatory follicle and the corpus luteum are the subject of this mini-review.

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“…We have been investigating the IMS involvement in the control of ovarian structures development and demise in the rat and human females for 40 years[7,10,18,42-45]. Recent proposal suggests to use transfer of circulating mononuclear cells from young fertile mammalian females, including humans, to aged females by a partial blood volume replacement to promote the fertility of females with aged or otherwise functionally affected ovaries, and to improve male infertility and some other functional tissue disorders as well[46].…”

Section: Ovarian Model Of Tissue Morphostasismentioning

confidence: 99%

“…Next, Burwell[5] indicated that the immune components play an essential function by managing self-tissue morphostasis and Fidler[6] proposed that the immunity is one of the many functions of lymphocytes. We have been investigating an involvement of immune components in the rat and human female reproduction since 1977[7]. Observation of immune components in the ovary resulted in the definition of the morphostatic “Tissue Control System” (TCS)[8,9].…”

Section: Introductionmentioning

confidence: 99%

Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment

Bukovský

2016

WJSC

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Blood mononuclear cells consist of T cells and monocyte derived cells. Beside immunity, the blood mononuclear cells belong to the complex tissue control system (TCS), where they exhibit morphostatic function by stimulating proliferation of tissue stem cells followed by cellular differentiation, that is stopped after attaining the proper functional stage, which differs among various tissue types. Therefore, the term immune and morphostatic system (IMS) should be implied. The TCS-mediated morphostasis also consists of vascular pericytes controlled by autonomic innervation, which is regulating the quantity of distinct tissues in vivo. Lack of proper differentiation of tissue cells by TCS causes either tissue underdevelopment, e.g., muscular dystrophy, or degenerative functional failures, e.g., type 1 diabetes and age-associated diseases. With the gradual IMS regression after 35 years of age the gonadal infertility develops, followed by a growing incidence of age-associated diseases and cancers. Without restoring an altered TCS function in a degenerative disease, the implantation of tissue-specific stem cells alone by regenerative medicine can not be successful. Transfused young blood could temporarily restore fertility to enable parenthood. The young blood could also temporarily alleviate aging diseases, and this can be extended by substances inducing IMS regeneration, like the honey bee propolis. The local and/or systemic use of honey bee propolis stopped hair and teeth loss, regressed varicose veins, improved altered hearing, and lowered high blood pressure and sugar levels. Complete regression of stage IV ovarian cancer with liver metastases after a simple elaborated immunotherapy is also reported.

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Ovarian function in adult rats treated with antithymocyte serum

Cited by 28 publications

References 4 publications

Mutant mouse models and their contribution to our knowledge of corpus luteum development, function and regression

Mutant mouse models and their contribution to our knowledge of corpus luteum development, function and regression

Chemokines in the corpus luteum: Implications of leukocyte chemotaxis

Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment

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