Ovarian function after autotransplantation of frozen-thawed human ovarian tissue: an experience of human ovarian grafting into two heterotopic sites

Kim, S.Samuel; Hwang, In Taek; Lee, Hoi-Chang; Kim, Dong Hoon

doi:10.1016/s0015-0282(03)02053-3

Cited by 6 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However all cases of successful postreimplantation pregnancy reported to date have utilised a whole ovary. To date, fewer than 15 patients worldwide have had their thawed ovarian tissue reimplanted via either orthotopic or heterotopic transplantation 56,68–73 . Within the last 18 months, two live births have been reported following the grafting of thawed ovarian tissue onto the native atrophic ovary following chemotherapy and radiation.…”

Section: Preservation Of Ovarian Tissuementioning

confidence: 99%

Fertility preservation in female oncology patients

Stern

Toledo

Gook

et al. 2006

Aust NZ J Obst Gynaeco

View full text Add to dashboard Cite

Survival rates for patients treated for the majority of childhood and young adult cancers have improved dramatically in recent years. Despite the high probability of survival, and often good quality of life in female survivors, until recently the concept of fertility preservation has not been seen to be an important component of the overall management of these patients. Over the last few years, various protection and preservation strategies have been developed, which may address potential reproductive concerns. Gametes or embryos may be frozen prior to potentially gonadotoxic cancer therapy, and ovarian tissue may be frozen and stored, with several pregnancies described after subsequent grafting. There is also increasing interest in the possibility of ovarian protection using gonadotrophin-releasing hormone analogues during chemotherapy, despite the lack of randomised controlled trials. Additionally, there are reports of novel protective strategies, including therapeutic alteration or manipulation of the sphingomyelin pathways. This review summarises methods of fertility protection and preservation currently available, as well as the emergence of promising new strategies.

show abstract

Section: Preservation Of Ovarian Tissuementioning

confidence: 99%

Fertility preservation in female oncology patients

Stern

Toledo

Gook

et al. 2006

Aust NZ J Obst Gynaeco

View full text Add to dashboard Cite

show abstract

Ovarian Tissue Cryopreservation: Ovarian Cortical Tissue Vitrification

Sugishita

Hashimoto²,

Yamochi³

et al. 2016

Gonadal Tissue Cryopreservation in Fertility Preservation

View full text Add to dashboard Cite

Effects of vitrification solutions and equilibration times on the morphology of cynomolgus ovarian tissues

Hashimoto¹,

Suzuki

Yamanaka³

et al. 2010

Reproductive BioMedicine Online

View full text Add to dashboard Cite

This study assessed the effects of vitrification solutions and equilibration times on morphology of cynomolgus ovarian tissues. Ovarian cortical sections (0.1-0.2 cm thickness) of seven cynomolgus monkeys were randomly allocated to either a control group or one of six vitrification groups. Ovarian tissue sections were vitrified ultra-rapidly by placing them directly into liquid nitrogen using two different vitrification solutions (VSEGP: 5.64 mol/l ethylene glycol+5% (w/v) polyvinylpyrrolidone+0.5 mol/l sucrose; and VSED: 3.22 mol/l ethylene glycol+2.56 mol/l dimethylsulphoxide+0.5 mol/l sucrose) after three different exposure times (5-20 min). After warming, follicle morphology was analysed using light and transmission electron microscopy. The proportion of morphologically normal follicles vitrified using VSED after a 5-min exposure was lower (P<0.05) than those vitrified by other conditions. The proportion of normally structured mitochondria in oocytes of preantral follicles vitrified after a 5-min exposure to VSED (56%) was lower (P<0.01) than those vitrified by other conditions (78-88%). Following tissue vitrification with VSED, the surface ratio of lysosome was increased compared with non-vitrified oocytes (1.64% versus 1.11%; P<0.05). These results indicate that VSEGP can support the morphology of vitrified preantral follicles and oocytes.

show abstract

Ovarian function after autotransplantation of frozen-thawed human ovarian tissue: an experience of human ovarian grafting into two heterotopic sites

Cited by 6 publications

References 0 publications

Fertility preservation in female oncology patients

Fertility preservation in female oncology patients

Ovarian Tissue Cryopreservation: Ovarian Cortical Tissue Vitrification

Effects of vitrification solutions and equilibration times on the morphology of cynomolgus ovarian tissues

Contact Info

Product

Resources

About