Ovarian follicular function is not altered by SARS–CoV-2 infection or BNT162b2 mRNA COVID-19 vaccination

Bentov, Yaakov; Beharier, Ofer; Moav-Zafrir, Arbel; Kabessa, Maor; Godin, Miri; Greenfield, Caryn; Ketzinel-Gilad, Mali; Broder, E Ash; Holzer, Hananel; Wolf, Dana; Oiknine‐Djian, Esther; Barghouti, Iyad; Goldman‐Wohl, Debra; Yagel, Simcha; Walfisch, Asnat; Klement, Anat Hersko

doi:10.1093/humrep/deab182

Cited by 113 publications

(127 citation statements)

References 12 publications

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“…The serum level of progesterone on the day of the trigger was lower in unexposed women, but the level measured on the retrieval day both in blood and follicular fluid was not different. Estradiol level was similar in both groups [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

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The Effects of SARS-CoV-2 Infection on Female Fertility: A Review of the Literature

Carp-Velişcu

Mehedințu

Frîncu

et al. 2022

IJERPH

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As the coronavirus pandemic is far from ending, more questions regarding the female reproductive system, particularly fertility issues, arise. The purpose of this paper is to bring light upon the possible link between COVID-19 and women’s reproductive health. This review emphasizes the effect of SARS-CoV-2 on the hormones, endometrium and menstrual cycle, ovarian reserve, follicular fluid, oocytes, and embryos. The results showed that endometrial samples did not express SARS-CoV-2 RNA. Regarding the menstrual cycle, there is a large range of alterations, but they were all reversible within the following months. The ovarian reserve was not significantly affected in patients recovering from both mild and severe infection in most cases, except one, where the levels of AMH were significantly lower and basal follicle-stimulating hormone (FSH) levels were increased. All COVID-19 recovered patients had positive levels of SARS-CoV-2 IgG in the follicular fluid. The amount of retrieved and mature oocytes and the fertilization rate were unharmed in three studies, except for one study, where the quantity of retrieved and mature oocytes was reduced in patients with higher levels of SARS-CoV-2 antibodies. The numbers of blastocysts, top-quality embryos, and euploid embryos were affected in most of the studies reviewed.

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Section: Resultsmentioning

confidence: 99%

“…They discovered that patients with positive serum levels of anti-COVID IgG also had levels of antibodies in the follicular fluid, and the results were similar between the two groups: infected and vaccinated. Anti-SARS-CoV-2 IgG after vaccination was present in the serum and follicular fluid starting with day 13 after the first dose [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

The Effects of SARS-CoV-2 Infection on Female Fertility: A Review of the Literature

Carp-Velişcu

Mehedințu

Frîncu

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…Fortunately, two studies have shown that both BNT162b2 and mRNA-1273 vaccination have no influence on sperm parameters, including sperm concentration, semen volume, sperm motility, sperm volume and total number of motile sperm ( Gonzalez et al , 2021 ; Safrai et al , 2021 ). Similarly, an assessment of follicular steroidogenesis and oocyte quality did not show any measurable difference when compared with unvaccinated women ( Bentov et al , 2021 ). Moreover, Orvieto et al (2021) reported that many IVF treatment parameters, such as the number of oocytes and mature oocytes retrieved, fertilization rate and the ratio of top-quality embryos (TQEs) per fertilized oocyte, did not significantly differ between the pre- and post-BNT162b2 vaccination groups ( Orvieto et al , 2021 ): these researchers had also found that COVID-19 infection could lead to a significantly lower proportion of TQEs ( Orvieto et al , 2021 ).…”

Section: Impact Of Mrna Vaccination On Human Fertilitymentioning

confidence: 83%

Effects of COVID-19 and mRNA vaccines on human fertility

et al. 2021

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The coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has precipitated a global health crisis of unprecedented proportions. Because of its severe impact, multiple COVID-19 vaccines are being rapidly developed, approved and manufactured. Among them, mRNA vaccines are considered as ideal candidates with special advantages to meet this challenge. However, some serious adverse events have been reported after their application, significantly increasing concerns about the safety and efficacy of the vaccines and doubts about the necessity of vaccination. Although several fertility societies have announced that COVID-19 mRNA vaccines are unlikely to affect fertility, there is no denying that the current evidence is very limited, which is one of the reasons for vaccine hesitancy in the population, especially in pregnant women. Herein, we provide an in-depth discussion on the involvement of the male and female reproductive systems during SARS-CoV-2 infection or after vaccination. On one hand, despite the low risk of infection in the male reproductive system or fetus, COVID-19 could pose an enormous threat to human reproductive health. On the other hand, our review indicates that both men and women, especially pregnant women, have no fertility problems or increased adverse pregnancy outcomes after vaccination, and, in particular, the benefits of maternal antibodies transferred through the placenta outweigh any known or potential risks. Thus, in the case of the rapid spread of COVID-19, although further research is still required, especially a larger population-based longitudinal study, it is obviously a wise option to be vaccinated instead of suffering from serious adverse symptoms of virus infection.

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“…Recently, an increased concern regarding COVID-19 vaccine and fertility has been reported as major cause for hesitancy in vaccine uptake [ 103 ]. Although no study has demonstrated an impact of SARS-CoV-2 infection and COVID-19 vaccination on ovarian function [ 104 ] or on sperm parameters [ 105 ], counselling with patients should be undertaken to help mitigate these concerns.…”

Section: Prevention Of Covid-19 In Pregnant Women With Vaccinesmentioning

confidence: 99%

Is the Immunization of Pregnant Women against COVID-19 Justified?

Principi

Esposito

2021

Vaccines

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Maternal immunization against some infectious diseases can offer significant advantages for women, preventing maternal morbidity and mortality, or for offspring, preventing fetal disease and conferring passive immunity to neonates. Recently, clinical trials specifically to evaluate the immunogenicity, safety, and tolerability of some of the available coronavirus disease 2019 (COVID-19) vaccines in pregnant and lactating women have been planned, initiated and, in some cases, completed. This paper discusses whether the immunization of pregnant women against COVID-19 is justified and presents knowledge about the immunogenicity and safety of mRNA COVID-19 vaccines for these subjects. The results of recent studies indicate that pregnant women are at increased risk of developing severe disease compared with nonpregnant women of the same age. Studies carried out with mRNA vaccines indicate that the immunogenicity, safety and tolerability of these preventive measures in pregnant women are not different from those in nonpregnant women of the same age. Moreover, antibodies are efficiently transferred through the placenta and can be detected in breastmilk, suggesting a potential prevention of infection in the child. All these findings authorize the use of mRNA vaccines in pregnant women to protect both the mother and the child. However, further studies with larger sample size and with follow-up of the pregnant women vaccinated during different periods of pregnancy and their children are needed to better characterize the immune response of pregnant women, to define when these vaccines should be administered to obtain the best protection, and to measure vaccine efficacy against virus variants in both mothers and infants. COVID-19 vaccines based on different technological platforms cannot presently be used, and their role in pregnant women should be clarified.

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Ovarian follicular function is not altered by SARS–CoV-2 infection or BNT162b2 mRNA COVID-19 vaccination

Cited by 113 publications

References 12 publications

The Effects of SARS-CoV-2 Infection on Female Fertility: A Review of the Literature

The Effects of SARS-CoV-2 Infection on Female Fertility: A Review of the Literature

Effects of COVID-19 and mRNA vaccines on human fertility

Is the Immunization of Pregnant Women against COVID-19 Justified?

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