Ovarian Follicular Development in Prepubertal Heifers is Influenced by Level of Dietary Energy Intake1

Bergfeld, E. G. M.; Kojima, F. N.; Cupp, Andrea S.; Wehrman, M. E.; Peters, K. E.; Garcia-Winder, M.; Kinder, J. E.

doi:10.1095/biolreprod51.5.1051

Cited by 73 publications

(56 citation statements)

References 31 publications

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“…In period 2, significantly different LW gain were achieved in the two groups of heifers: 730 g/day for the restricted group versus 1300 g/day for the overfed group. Such LW gain is close to that observed in French farms (Troccon 1993, Gaboriau 2002) as well as in other studies on heifers (Bergfeld et al 1994, Saumande et al 1998, Carson et al 2000, Armstrong et al 2001, Chelikani et al 2003. The increase from 950 g/day in period 1 to 1300 g/day in period 2 for the overfed group could be due to an improvement of nutritional efficiency during the 4 months of experiment.…”

Section: Growth Rate Body Weight and Bcssupporting

confidence: 90%

Reduction of body-weight gain enhances in vitro embryo production in overfed superovulated dairy heifers

Fréret¹,

Grimard²,

Ponter³

et al. 2006

Reproduction

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The aim of our study was to test whether a reduction in dietary intake could improve in vitro embryo production in superovulated overfed dairy heifers. Cumulus-oocyte complexes of 16 Prim' Holstein heifers (14 6 1 months old) were collected by ovum pick-up (OPU), every 2 weeks following superovulation treatment with 250 mg FSH, before being matured and fertilized in vitro. Embryos were cultured in Synthetic Oviduct Fluid medium for 7 days. Heifers were fed with hay, soybean meal, barley, minerals and vitamins. From OPU 1 to 4 (period 1), all heifers received individually for 8 weeks a diet formulated for a 1000 g/day live-weight gain. From OPU 5 to 8 (period 2), the heifers were allocated to one of two diets (1000 or 600 g/day) for 8 weeks. Heifers' growth rates were monitored and plasma concentrations of metabolites, metabolic and reproductive hormones were measured each week. Mean live-weight gain observed during period 1 was 950 6 80 g/day (n 5 16). In period 2 it was 730 6 70 (n 5 8) and 1300 6 70 g/day (n 5 8) for restricted and overfed groups respectively. When comparing period 1 and period 2 within groups, significant differences were found. In the restricted group, a higher blastocyst rate, greater proportions of grade 1-3 and grade 1 embryos, associated with higher estradiol at OPU and lower glucose and b-hydroxybutyrate, were observed in period 2 compared with period 1. Moreover, after 6 weeks of dietary restriction (OPU 7), numbers of day 7 total embryos, blastocysts and grade 1-3 embryos had significantly increased. On the contrary, in the overfed group, we observed more <8 mm follicles 2 days before superovulation treatment, higher insulin and IGF-I and lower nonesterified fatty acids in period 2 compared with period 1 (no significant difference between periods for embryo production). After 6 weeks of 1300 g/day live-weight gain (OPU 7), embryo production began to decrease. Whatever the group, oocyte collection did not differ between period 1 and 2. These data suggest that following a period of overfeeding, a short-term dietary intake restriction (6 weeks in our study) may improve blastocyst production and embryo quality when they are low. However, nutritional recommendations aiming to optimize both follicular growth and embryonic development may be different.

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Section: Growth Rate Body Weight and Bcssupporting

confidence: 90%

Reduction of body-weight gain enhances in vitro embryo production in overfed superovulated dairy heifers

Fréret¹,

Grimard²,

Ponter³

et al. 2006

Reproduction

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“…The follicular development pattern observed in this study, increasing linearly in time, agrees with Bergfeld et al (1994), who demonstrated a linear increase in the DF maximum diameter of prepubertal heifers approaching puberty and also demonstrated that greater energy accelerated follicular growth. The mechanism by which energy intake infl uences follicle development is not yet fully elucidated.…”

Section: Discussionsupporting

confidence: 90%

Effect of chronic infusion of leptin and nutrition on sexual maturation of zebu heifers1

Carvalho

Diniz-Magalhães

Pereira

et al. 2013

Journal of Animal Science

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ABSTRACT:The amount of fat in the carcass has been proposed as a regulator of initiation of puberty in cattle. To test if changes in energy intake and in circulating leptin concentration are each capable of altering age, BW, and body composition at puberty, 36 prepubertal Nellore heifers, 18 to 20 mo old, 275.8 ± 17.2kg BW, and BCS of 5 ± 0.5 (1 to 9 scale), were randomly assigned to each of 3 treatments (n = 12): High (high energy diet), Low (low energy diet), and LL [low energy diet + ovine leptin (oLeptin)]. Diets were formulated to promote BW gain of 0.4 kg/d (groups Low and LL) or 1.2 kg/d (High group). After 14 d of adjustment to diet, heifers in LL group received subcutaneous injections of oLeptin at 4.8 μg/kg BW twice a day for 56 d. Groups High and Low received similar injections of 2 mL saline solution. Age at puberty was considered to be the age on fi rst detection of a corpus luteum, confi rmed by plasma concentrations of progesterone of >1 ng/mL. Heifers were slaughtered on the second day after fi rst corpus luteum detection. Expression of leptin gene was quantifi ed by real-time PCR using ribosomal protein-L19 (RP-L19) as a control gene. Leptin administration increased

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“…Sirois and Fortune, 1988;Sartori et al, 2002;Wolfenson et al, 2004). Significantly fewer experiments have been performed on beef heifers (Hooper et al, 1993;Bergfeld et al, 1994;Evans et al, 1994;Gasser et al, 2006) and we found no paper dealing with dual-purpose breeds of cattle. Czech Fleckvieh heifers rank among dual-purpose breeds, reaching puberty at 8-10 months, weighing 340-360 kg at 12 months, and with milk yield of 5 800 kg at the first lactation.…”

mentioning

confidence: 58%

“…There are many factors affecting the reproductive efficiency of heifers, for example body weight (Chebel et al, 2007), metabolic status (Bergfeld et al, 1994;Ferguson, 2005), BCS (Sejrsen et al, 1999), heat stress (Wilson et al, 1998a) and sufficient ovarian activity (Fortune, 1993).…”

mentioning

confidence: 99%

A comparison of the follicular dynamics in heifers of the Czech Fleckvieh and Holstein breeds

Šichtař¹,

Tolman²,

Rajmon³

et al. 2010

CZECH J ANIM SCI

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Differences in follicular development and repeatability of follicular growth pattern among Czech Fleckvieh (n = 20) and Holstein (n = 23) heifers were investigated. Follicular dynamics was evaluated by daily sonographic scanning during three interovulatory intervals. The mean duration of the interovulatory interval was 20.66 ± 0.32 days, no differences between breeds were observed. The proportion of the nonalterna-ting pattern was nearly the same as that of the alternating pattern (54% and 46%, respectively). The majority of IOIs ≤ 21 days were of the 2-wave pattern (71%) whereas only 29% of them were of the 3-wave pattern. Conversely, the majority of IOIs ≥ 22 days were of the 3-wave pattern (84%), whereas only 16% were of the 2-wave pattern. Differences could be observed in the Czech Fleckvieh heifers. Comparing 2-and 3-wave interovulatory intervals, 44.2% of the heifers exhibited 3 waves and 55.8% of the heifers exhibited 2 waves of follicular growth. The ratio of 3-to 2-wave heifers was about the same in the Holstein breed; in Czech Fleckvieh 2-wave cycles slightly dominated (11/12, 8/12; respectively). In Holstein heifers, the first follicular wave occurred 0.92 ± 0.15 days after ovulation in 2-wave interovulatory intervals, and the emergence of the first wave in 2-wave Czech Fleckvieh heifers appeared later (P < 0.05), 1.83 ± 0.3 days after ovulation. The maximal size reached by the dominant follicles in all animals and in the Czech Fleckvieh differed in the first and in the second wave of 2-wave cycles (P < 0.05). In 3-wave interovulatory intervals the dominant follicles in the second wave differed (P < 0.05) from the mean diameters of the first and the third wave in the Czech Fleckvieh. The ovulatory follicles were significantly (P < 0.05) smaller in 2-wave than in 3-wave interovulatory intervals among all animals and between the Holstein and Czech Fleckvieh heifers. In conclusion, we found a similar pattern of ovarian follicular dynamics in Czech Fleckvieh and Holstein heifers kept under identical nutritional and environmental conditions. Whether the significant difference in the emergence of the 1 st follicular wave in 2-wave IOIs between C and H heifers is of real biological significance is ambiguous.

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Ovarian Follicular Development in Prepubertal Heifers is Influenced by Level of Dietary Energy Intake1

Cited by 73 publications

References 31 publications

Reduction of body-weight gain enhances in vitro embryo production in overfed superovulated dairy heifers

Reduction of body-weight gain enhances in vitro embryo production in overfed superovulated dairy heifers

Effect of chronic infusion of leptin and nutrition on sexual maturation of zebu heifers1

A comparison of the follicular dynamics in heifers of the Czech Fleckvieh and Holstein breeds

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