Ovarian fibrothecoma with minor sex cord elements: a case report

Abstract

Ovarian fibroma is the most common sex cord stromal tumour of ovary accounting to 1-5% of all ovarian tumours. Minor sex cord elements in ovarian fibroma are a rare entity occupying less than 10% of tumour area. To the best of our knowledge only 20 cases has been reported till date. This case is presented because of its rarity. Authors reported a case of fibrothecoma with minor sex cord elements in a 70yr old postmenopausal women who presented with postmenopausal bleeding with abdominal mass.

Ovarian fibroma: A diagnostic dilemma

“…Macroscopically, ovarian fibromas are firm, white masses with smooth lobulated appearance, sometimes cystic degeneration or stromal edema is also noted. This generally resembles a uterine leiomyoma [9] . Microscopically, intersecting bundles of spindle cells producing collagen are seen.…”

“…Surgery is the mainstay of treatment which can be performed by laparotomy or laparoscopically. Salpingo-ovariotomy should be performed in perimenopausal or postmenopausal women while cystectomy should be considered in younger patients [9] . In our case, conservation of the ovary was not possible as no ovarian tissue could be separated from the large solid mass and there was high index of suspicion for malignancy.…”

“…Minor sex cord elements are seen which are defined as sex cord elements occupying no more than 10% of the area of the tumor on any slide. These are seen as small nests of cells resembling cells of sex cord type, granulosa cells or sertoli cells [9] . These minor sex cord elements are positive for inhibin, calretinin, CD99, CD56, antikeratin antibody KL1 and MIC on immunohistochemical analysis of ovarian fibroma [9] .…”

“…These are seen as small nests of cells resembling cells of sex cord type, granulosa cells or sertoli cells [9] . These minor sex cord elements are positive for inhibin, calretinin, CD99, CD56, antikeratin antibody KL1 and MIC on immunohistochemical analysis of ovarian fibroma [9] .…”