Ovarian Fibroma: A Clinico-pathological Study of 23 Cases with Review of Literature

Abstract

About the Author AbstractPurpose The purpose of this study was to correlate the clinical findings, RMI-4 index and frozen section, in cases of ovarian fibroma with the final histopathology.

Calcified Bilateral Ovarian Fibroma in a 15 Year Old Female: Case Report and Literature Review

“…The pressure effects on surrounding structures may give lower gastro-intestinal and urinary symptoms. However it can be asymptomatic and may only be an incidental finding on routine gynecologic examination and evaluation, therefore a high index of suspicion is required for accurate pre-operative diagnosis [13,14]. In this case report the patient had an incidental ultrasound scanning finding of an ovarian mass as a pre-pubertal girl, which had progressively increased in size and become symptomatic overtime.…”

“…Ovarian fibromas can be associated with ascites especially in large tumors in which about 40-50% of tumors >5 cm in widest diameter present with ascites, the fluid usually escapes from its edematous surface [13,14]. The Ovarian cortex, from which the fibroma arises, does not have lymphatic vessels, this makes large amount of fluid to escape from large tumors [13].…”

“…The diagnosis can only be confirmed on histology. Microscopically these tumors consist of fibroblastic cells that are spindle shaped with cytoplasm producing abundant collagen [8,9,14] however fibrothecoma contains a small proportion of theca cells containing intracellular lipids in addition to the spindle shaped fibroblastic cells and this may show estrogenic activity [17].…”

“…Fibromas can occur as an isolated lesion or as part of a syndrome. These syndromes include Meig Syndrome, where the benign ovarian fibroma is associated with ascites and unilateral right sided pleural effusion and this is seen in 1% of ovarian fibromas [14]. Others include; Gorlin-Golt syndrome is an uncommon multi-systemic autosomal dominant disorder also known as Nevoid basal cell carcinoma and its features includes Bilateral Calcified Ovarian fibromas, multiple basal cell carcinoma of the skin, keratocystic odontogenic tumours, anomalies of the vertebral and skull, calcified dural fold, hypertelorism, cardiac fibromas, fetal rhabdomyomas and rhabdomyosarcomas [7,12].…”

A Case Report of Ovarian Fibrothecoma in a Premenopausal Women with Recurrent Menorrhagia

“…The comas resemble theca interna cells of the ovary and are composed of lipids. There is a large histological and immunohistochemical overlap between the two structures that resulted in the term "fibrothecoma" [6]. These tumors affect all age groups and in 70% of the cases, the patients are diagnosed as having Stage I lesions at presentation, contrary to the epithelial ovarian tumors where patients present with Stage III or IV disease [7].…”