Ovarian failure and polycystic ovary syndrome

Petríková, Jana; Lazúrová, Ivica

doi:10.1016/j.autrev.2011.11.010

Cited by 54 publications

(43 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been speculated that this association may be the consequence of the relative predominance of estrogen over progesterone, a characteristic of PCOS that triggers an exacerbated immune response, hence the appearance of autoimmune diseases [2,22,23].…”

Section: Discussionmentioning

confidence: 99%

Polycystic ovary syndrome and chronic autoimmune thyroiditis

Novais

Benetti‐Pinto

Garmes

et al. 2014

Gynecological Endocrinology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Polycystic ovary syndrome and chronic autoimmune thyroiditis

Novais

Benetti‐Pinto

Garmes

et al. 2014

Gynecological Endocrinology

View full text Add to dashboard Cite

show abstract

“…Polymorphisms of susceptibility genes in the first disorder, HT, may influence the occurrence and characteristics of the second disorder, PCOS, and vice versa. Such possible connections will be Anovulatory infertility, gestational diabetes mellitus, pregnancyinduced hypertension, and preterm delivery risk (66,122) Clomiphene citrate resistance risk (123) reviewed in more detail. Furthermore, HT is the most prevalent autoimmune disorder (16), and, in PCOS, a possible role of autoimmune phenomena in the etiology has been implied (27,33).…”

Section: Joint Etiology and Pathogenesismentioning

confidence: 99%

“…Inadequate vitamin D intake is linked to a higher incidence of autoimmune disorders (66,67). Vitamin D exerts its action via VDR which is expressed in a wide variety of tissues, also on lymphocytes, monocytes, and dendritic cells (65,68).…”

Section: The Role Of Vitamin D Deficiencymentioning

confidence: 99%

See 1 more Smart Citation

MECHANISMS IN ENDOCRINOLOGY: Thyroid and polycystic ovary syndrome

Gaberšček

Zaletel

Schwetz

et al. 2015

European Journal of Endocrinology

View full text Add to dashboard Cite

Thyroid disorders, especially Hashimoto's thyroiditis (HT), and polycystic ovary syndrome (PCOS) are closely associated, based on a number of studies showing a significantly higher prevalence of HT in women with PCOS than in controls. However, the mechanisms of this association are not as clear. Certainly, genetic susceptibility contributes an important part to the development of HT and PCOS. However, a common genetic background has not yet been established. Polymorphisms of the PCOS-related gene for fibrillin 3 (FBN3) could be involved in the pathogenesis of HT and PCOS. Fibrillins influence the activity of transforming growth factor beta (TGFb). Multifunctional TGFb is also a key regulator of immune tolerance by stimulating regulatory T cells (Tregs), which are known to inhibit excessive immune response. With lower TGFb and Treg levels, the autoimmune processes, well known in HT and assumed in PCOS, might develop. In fact, lower levels of TGFb1 were found in HT as well as in PCOS women carrying allele 8 of D19S884 in the FBN3 gene. Additionally, vitamin D deficiency was shown to decrease Tregs. Finally, high estrogen-to-progesterone ratio owing to anovulatory cycles in PCOS women could enhance the immune response. Harmful metabolic and reproductive effects were shown to be more pronounced in women with HT and PCOS when compared with women with HT alone or with controls. In conclusion, HT and PCOS are associated not only with respect to their prevalence, but also with regard to etiology and clinical consequences. However, a possible crosstalk of this association is yet to be elucidated.

show abstract

“…The etiologies include genetic causes, enzymatic and gonadotropin defects, ovarian insults, and autoimmunity. Approximately 20-30% of the cases with POI have associated autoimmune disorders [1]. A variety of auto-immune conditions such as endocrinopathy, thyroid diseases, addision’s disease, rheumatoid arthritis and polyglandular syndrome have been found in POI women.…”

Section: Introductionmentioning

confidence: 99%

Serologic autoimmunologic parameters in women with primary ovarian insufficiency

Zhang

Qiao

et al. 2014

BMC Immunol

View full text Add to dashboard Cite

BackgroundPrimary ovarian insufficiency (POI) is heterogeneous disease defined by amenorrhea or premature depletion of ovarian follicles before the age of 40 years. The etiology of POI is still unclear. The purpose of this study is to evaluate whether women with POI have an elevated serum levels of autoimmunologic parameters.MethodsThe serum from peripheral blood samples which come from 96 POI patients and 100 age-matched health women were analyzed for a series of autoimmune antibodies using protein microarray. The antibodies to double-stranded DNA (ds-DNA), histone (HIS), nuclear ribonucleoprotein (RNP), Sjogren’s syndrome A (SSA/Ro), Sjogren’s syndrome B (SSB/La) and Smith antigen, Jo-1, scleroderma-associated antigen (Scl-70) and centromere (CEN), zona pellucid (ZP), adrenocortical antibodies (ACA),Rheumatoid factor (RF), glomerular basement membrane (GBM), proliferating cell nuclear antigen (PCNA), myeloperoxidase (MPO), proteinase 3 (PR3), thyroid microsomal antibody and antinuclear antibody (ANA)were analyzed.ResultsAmong the 96 women with POI and 100 age-matched health controls, women with POI had significantly elevated circulation levels of Jo-1 and PR3 (p = 0.010 and p = 0.001) whereas circulation levels of ANAs, dsDNA, histone, RNP, Sm, Scl-70, SSA, SSB, CEN, ZP, ACA, RF, GBM, PCNA, MPO and TM antibodies were similar between the two groups.ConclusionsThis study shows that the autoimmune antibodies JO-1 and PR3 were significantly higher in POI women group which suggested that these antibodies may have played special role in POI, but the evaluation of the exact pathways of them remains to be determined.

show abstract

Ovarian failure and polycystic ovary syndrome

Cited by 54 publications

References 86 publications

Polycystic ovary syndrome and chronic autoimmune thyroiditis

Polycystic ovary syndrome and chronic autoimmune thyroiditis

MECHANISMS IN ENDOCRINOLOGY: Thyroid and polycystic ovary syndrome

Serologic autoimmunologic parameters in women with primary ovarian insufficiency

Contact Info

Product

Resources

About