Ovarian endometrioma—Risks factors of ovarian cancer development

Kobayashi, Hiroshi; Sumimoto, Kazuhiro; Kitanaka, Takashi; Yamada, Yoshihiko; Sado, Toshiyuki; Sakata, Mariko; Yoshida, Shozo; Kawaguchi, Ryuji; Kanayama, Seiji; Shinmoto, Hiroshi; Shoji, Hirokazu; Tsuji, Yoriko; Ueda, Sachiyo; Terao, Toshihiko

doi:10.1016/j.ejogrb.2007.06.017

Cited by 149 publications

(99 citation statements)

References 17 publications

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“…Retrograde flow of menstrual blood may lead to endometriosis (2). Individuals with endometriosis require a long follow-up, with particular attention paid not only to dysmenorrhea and infertility but also to potential malignant transformation (3). In Japan, <1% of women with endometriosis develop ovarian cancer (3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Cyst fluid hemoglobin species in endometriosis and its malignant transformation: The role of metallobiology

Iwabuchi¹,

Yoshimoto

Shinmoto

et al. 2016

Oncology Letters

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Abstract. The aim of the present study was to assess the relative concentrations of hemoglobin (Hb) species in endometriosis as a possible indicator of malignancy. Electronic absorption spectroscopy was employed to quantify the Hb species present in the cyst fluid collected from 8 patients with endometriosis-associated ovarian cancer (EAOC), and compared with those present in the cyst fluid of 35 patients with benign endometriotic cysts. The 620/580 nm ratio in the electronic absorption spectrum, which was used as a surrogate indicator of the methemoglobin (metHb)/(oxyhemoglobin+metHb) ratio, was measured in each cyst fluid by ultraviolet/visible grating spectrophotometric microplate reader. The optimal cutoff value was defined according to the analysis of receiver operating characteristic (ROC) curve. The sensitivity and specificity of detection were calculated on the basis of the cutoff value to differentiate EAOC from endometriosis. The 620/580 nm ratio of cyst fluid in EAOC patients was much lower than that measured in women with benign cysts (0.389±0.266 vs. 0.666±0.188, P=0.021). ROC curve analysis performed using 0.35 as the optimal cutoff value indicated that the 620/580 nm ratio had a sensitivity, specificity, positive predictive value (PPV) and negative predictive value of 62.5, 100.0, 100.0 and 92.1%, respectively, in the diagnosis of EAOC. In conclusion, metHb is one of the most abundant Hb species in benign cysts, and the absorption 620/580 nm ratio of cyst fluid exhibits high specificity and PPV as a surveillance test for the early detection of malignant transformation of endometriosis. Thus, metallobiology highlights diverse features involved in Hb homeostasis and the pathogenesis of malignant transformation of endometriosis.

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Section: Introductionmentioning

confidence: 99%

Cyst fluid hemoglobin species in endometriosis and its malignant transformation: The role of metallobiology

Iwabuchi¹,

Yoshimoto

Shinmoto

et al. 2016

Oncology Letters

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“…It is reported that the prevalence of ovarian cancer was 0% among women with ova-rian endometriomas that were less than 6 cm in diameter [1]. But it is recommended that patients with endometriosis, regardless of patient age or tumor size, undergo careful monitoring to detect changes in growth or the formation of solid regions for as long as the lesion is present.…”

Section: Discussionmentioning

confidence: 99%

“…It is reported that risk factors of malignant transformation are older age, postmenopausal status, and larger tumor diameter were associated with a higher prevalence of cancer development. They defined postmenopausal women with ovarian endometriosis of 9 cm or larger in diameter as a high risk group and recommended extensive therapy, including surgery [1]. This report demonstrates a case of borderline ovarian clear cell tumor arising from endometriosis, whose size was small and unchanged for 12 years.…”

Section: Introductionmentioning

confidence: 95%

“…The authors further analyzed risk factors of malignant transformation and found that older age, postmenopausal status, and larger tumor diameter were associated with a higher prevalence of cancer development. They defined postmenopausal women with ovarian endometriosis of 9 cm or larger in diameter as a high risk group and recommended extensive therapy, including surgery [1].…”

Section: Discussionmentioning

confidence: 99%

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A Case Report: Cystic Clear Cell Tumor of Borderline Malignancy of the Ovary

Matsubara¹,

Fujioka²,

Matsubara³

et al. 2014

OJOG

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Introduction: Ovarian borderline clear cell tumor is a very rare tumor accounting for less than 1% of borderline ovarian tumors. Currently, only 30 cases of borderline clear cell tumors have been reported. This borderline ovarian clear cell tumor often arises from endometriosis. But there are no definitive guidelines for the management of endometriosis with malignant transformation due to a lack of understanding of the mechanistic details that mediate the transformation of endometriosis into ovarian cancer. Case: A 52-year-old woman (G2 P2) who periodically underwent ultraso-nography over the course of 12 years in order to follow the endometrioma present in her left ovary. The diameter of the lesion was 46 mm and it remained largely unchanged. However, a solid region within the ovarian cyst was detected. After the surgery, the final pathological diagnosis was cystic clear cell tumor of borderline malignancy. Conclusion: It reported that risk factors of malignant transformation are older age, postmenopausal status, and larger tumor diameters were associated with a higher prevalence of cancer development. But it is recommended that patients with endometriosis, regardless of patient age or tumor size, undergo careful monitoring to detect changes in growth or the formation of solid regions for as long as the lesion is present.

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“…Di¤er bir görüfl de yap›lan tubal ligasyonun koruyucu faktör olmas›ndaki ana neden retrograd menstruasyon yoluyla geliflebilecek endometriozisi önleyip endometriomalarla birlikte geliflebilecek BHOK insidans›n› azaltt›¤›d›r. Literatürde endometriomalardan geliflen malign de¤iflim için risk faktörleri olarak ileri yafl, multikistik görünüm, endometrioma içerisine do¤ru geliflmifl papiller yap› ve endometrioma büyüklü¤ünün 9 cm ve üzerinde olmas› belirtilmektedir (10) . ‹mmunohistokimyasal çal›flmalar sonucunda epitelyal subtipleriyle karfl›laflt›r›ld›¤›nda Bcl2 iliflkili protein bax, p21 ve siklin E'de pozitif boyanma, p53, siklin A, ve HER2'de zay›f boyanma izlenmektedir.…”

Section: G‹r‹fiunclassified