Ovarian Dysgerminomas in Two Mountain Chicken Frogs (Leptodactylus Fallax)

Fitzgerald, Scott D.; Duncan, Ann E.; Tabaka, Chris; Garner, Michael M.; Dieter, April; Kiupel, Matti

doi:10.1638/06-015.1

Cited by 17 publications

(12 citation statements)

References 9 publications

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“…7,8,11,14,16 Ovarian tumors in domestic species are classified into three categories based on the type of prevailing neoplastic cell: sex cord tumors that include granulosa cell tumors, epithelial cell tumors, including adenomas and adenocarcinomas, and germ cell tumors that include dysgerminomas and teratomas. 7 In human females, germ cell tumors account for 30% of ovarian tumors, but malignant germ cell tumors account for only 1-3% of all ovarian tumors.…”

Section: Brief Communicationmentioning

confidence: 99%

PRESUMPTIVE DYSGERMINOMA IN AN ORANGE-SPOT FRESHWATER STINGRAY (POTAMOTRYGON MOTORO)

Jafarey¹,

Berlinski²,

Hanley³

et al. 2015

Journal of Zoo and Wildlife Medicine

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A captive-born, 13-yr-old female orange-spot freshwater stingray, (Potamotrygon motoro), presented with an acute caudodorsal swelling. Ultrasonography revealed an intracoelomic mass of mixed echogenicity containing fluid pockets. The ray was euthanatized and gross postmortem examination confirmed the presence of a fluid-filled coelomic mass in the region of the reproductive tract. The mass was identified histologically as a malignant round cell tumor of the ovary. Although immunohistochemistry for protein gene product 9.5 (PGP9.5), octamer-3/4 (OCT-3/4), and inhibin was attempted, antibodies that had been validated in mammalian species did not cross-react with stingray control tissues and did not label neoplastic cells. The final diagnosis was a presumptive dysgerminoma.

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Section: Brief Communicationmentioning

confidence: 99%

PRESUMPTIVE DYSGERMINOMA IN AN ORANGE-SPOT FRESHWATER STINGRAY (POTAMOTRYGON MOTORO)

Jafarey¹,

Berlinski²,

Hanley³

et al. 2015

Journal of Zoo and Wildlife Medicine

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“…Other spontaneous neoplasias in X. laevis include tumors of the digestive track [77], melanophoromas, and more rarely, renal carcinoma and nephroblastoma [75, 78]. We have recently described a type of ovarian tumor in X. laevis [2]; a similar tumor was also described in another anuran species ( Leptodactylus fallax ; [79]).…”

Section: Evidence Of Neoplasia In Metazoanmentioning

confidence: 99%

Comparative study of tumorigenesis and tumor immunity in invertebrates and nonmammalian vertebrates

Robert

2010

Developmental & Comparative Immunology

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Despite intense study in mammals, the different roles played by the immune system in detecting (immunosurveillance), controlling and remodeling (immunoediting) neoplasia, and perhaps in metastasis are not fully understood. In this review, I will present evidence of neoplasia and invasive malignancy, as well as tumor immunity in invertebrates and nonmammalian vertebrates. I will also present a comparative and evolutionary view of the complex interactions between neoplasia and the host immune system. Overall, I wish to go beyond the too simplistic dichotomy between invertebrates with innate immunity that are only affected with benign neoplasia and vertebrates with adaptive immunity that are affected by metastatic malignancies or cancer.

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“…Cells within the tumor nodules resembled seminoma cells of the testis but since the sex of the frog was female, the equivalent tumor in females is ovarian dysgerminoma, one of the three main types of ovarian tumors. Until recently (28), this neoplasm had never been reported in amphibians. Slides of these tumors were submitted to the Registry of Tumors in Lower Animals in May of 2000.…”

Section: Tumor Occurrence In Xenopusmentioning

confidence: 99%

Tumorigenesis and anti-tumor immune responses in Xenopus

Goyos

Robert²

2009

Front Biosci

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Despite intense study, the role of the immune system in detecting (immunosurveillance), controlling and remodeling (immunoediting) neoplasia remains elusive. We present here a comparative view of the complex interactions between neoplasia and the host immune system. We provide evidence, in the amphibian Xenopus laevis, consistent with an evolutionarily conserved and crucial role of the immune system in controlling neoplasia, which involves a striking variety of anti-tumoral immune effectors including conventional CTLs, classical MHC class Ia unrestricted CTLs (CCU-CTLs) that interact with nonclassical MHC class Ib molecules, CD8 NKT-like cells and NK cells. We also review the tumors found in X. laevis with an emphasis on thymic lymphoid tumors and a rare ovarian dysgerminoma. Finally, we consider the use of X. laevis for in vivo study of tumorigenesis. Given our current knowledge, the experimental systems already established in X. laevis, and the rapid accumulation of genetic resources for the sister species Silurana (Xenopus) tropicalis, it is our conviction that these species provide an ideal alternative to the murine system for studying tumorigenesis and tumor immunity.

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Ovarian Dysgerminomas in Two Mountain Chicken Frogs (Leptodactylus Fallax)

Cited by 17 publications

References 9 publications

PRESUMPTIVE DYSGERMINOMA IN AN ORANGE-SPOT FRESHWATER STINGRAY (POTAMOTRYGON MOTORO)

PRESUMPTIVE DYSGERMINOMA IN AN ORANGE-SPOT FRESHWATER STINGRAY (POTAMOTRYGON MOTORO)

Comparative study of tumorigenesis and tumor immunity in invertebrates and nonmammalian vertebrates

Tumorigenesis and anti-tumor immune responses in Xenopus

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