Ovarian conservation for young women with clinical stage IB–IIB cervical cancer in Japan

Matsuo, Koji; Shimada, Muneaki; Mikami, Mikio

doi:10.3802/jgo.2017.28.e60

Cited by 9 publications

(12 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, it is paramount to proactively identify the patients who do not have an increased risk of ovarian metastasis . This is particularly applicable to the Japanese population where ovarian conservation is substantially low (0.5% for stage IB–IIB in Japan versus ∼40% for stage IB in the United States) …”

Section: Discussionmentioning

confidence: 99%

“…18,20 This is particularly applicable to the Japanese population where ovarian conservation is substantially low (0.5% for stage IB-IIB in Japan versus 40% for stage IB in the United States). 26,41 In this study, women without risk factors for ovarian metastasis represented nearly half of the study population of age <50 years with stage IB-IIB cervical cancer (ovarian metastasis risk, 0.14%). In addition, women aged <50 years with adenocarcinoma alone represented nearly one fifth of the study population (ovarian metastasis risk, 0.17%).…”

Section: Cancer Therapy and Preventionmentioning

confidence: 99%

See 1 more Smart Citation

Identifying a candidate population for ovarian conservation in young women with clinical stage IB–IIB cervical cancer

Matsuo

Shimada

Yamaguchi

et al. 2017

Intl Journal of Cancer

Self Cite

View full text Add to dashboard Cite

This study seeks to identify risk factors associated with ovarian metastasis and to characterize a population with minimum risk of ovarian metastasis in young women with stage IB-IIB cervical cancer. This was a nation-wide multicenter retrospective study in Japan examining consecutive cases of surgically-treated women with clinical stage IB-IIB cervical cancer who had oophorectomy at radical hysterectomy (n = 5,697). Multivariable analysis was performed to identify independent risk factors for ovarian metastasis. Ovarian metastasis was seen in 70 (1.2%, 95% confidence interval 0.9-1.5) cases. In the entire cohort, adenocarcinoma, lympho-vascular space invasion, uterine corpus tumor invasion, and pelvic/para-aortic nodal metastases remained independent risk factors for ovarian metastasis (all, adjusted-p< 0.05). In a sensitivity analysis of 3,165 women aged <50 years (ovarian metastasis, 1.0%), adenocarcinoma, parametrial tumor involvement, uterine corpus tumor involvement, and pelvic/para-aortic nodal metastases remained independent risk factors for ovarian metastasis (all, adjusted-P < 0.05). In the absence of these five risk factors (representing 46.1% of women aged <50 years), the incidence of ovarian metastasis was 0.14%. With the presence of adenocarcinoma alone (representing 18.9% of women aged <50 years), the incidence of ovarian metastasis was 0.17% and was not associated with increased risk of ovarian metastasis compared to the subgroup without any risk factors (p = 0.87). In conclusion, nearly two thirds of women aged <50 years with clinical stage IB-IIB cervical cancer had no risk factor for ovarian metastasis or had adenocarcinoma alone: these subgroups had ovarian metastasis rates of around 0.1% and may be a candidate population for ovarian conservation at surgical treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Cancer Therapy and Preventionmentioning

confidence: 99%

Identifying a candidate population for ovarian conservation in young women with clinical stage IB–IIB cervical cancer

Matsuo

Shimada

Yamaguchi

et al. 2017

Intl Journal of Cancer

Self Cite

View full text Add to dashboard Cite

show abstract

“…This is a secondary analysis of a prior nationwide multicenter retrospective study conducted in Japanese Gynecologic Oncology Group (JGOG)-designated institutions [18][19][20][21][22][23][24][25]. The study concept and participation call for this landmark collaborator study was initially announced to all JGOG-designated institutions (182 sites), and 116 (63.7%) of these sites voluntarily participated in this study (JGOG-1072S).…”

Section: Data Sourcementioning

confidence: 99%

“…Detail of the utilized methodology was previously described [18][19][20][21][22][23][24][25]. Briefly, data collection took place at each study site by deploying a universal data entry form for the collection of clinical, tumor, treatment and survival information from archived medical records.…”

Section: Data Sourcementioning

confidence: 99%

See 1 more Smart Citation

Significance of Malignant Peritoneal Cytology on the Survival of Women with Early-Stage Cervical Cancer: A Japanese Gynecologic Oncology Group Study

Matsuo

Shimada

Matsuzaki

et al. 2019

JCM

Self Cite

View full text Add to dashboard Cite

This study examined the association between peritoneal cytology and survival in early-stage cervical cancer. This is a nationwide multicenter retrospective study, examining consecutive women with clinical stage IB1-IIB cervical cancer who underwent radical hysterectomy with available peritoneal cytology results from 2004–2008. Propensity score inverse probability of treatment weighting was used to assess the impact of malignant peritoneal cytology on survival. Among 1409 analyzed cases, 88 (6.2%) had malignant peritoneal cytology. On weighted models, malignant peritoneal cytology was associated with decreased disease-free survival (hazard ratio (HR) 1.78, 95% confidence interval (CI) 1.36–2.32) and overall survival (OS, HR 1.93, 95% CI 1.44–2.59). On sensitivity analyses, malignant peritoneal cytology was associated with decreased OS in adenocarcinoma/adenosquamous carcinoma, high-risk early-stage disease and those who received concurrent chemo-radiotherapy. However, among women who received postoperative systemic chemotherapy, malignant peritoneal cytology was not associated with OS (HR 1.21, 95% CI 0.72–2.04). A systematic review, including our results, showed that malignant peritoneal cytology was associated with decreased OS (HR 4.03, 95% CI 1.81–8.99) and increased recurrence in squamous carcinoma (odds ratio 1.89, 95% CI 1.05–3.39) and adenocarcinoma (odds ratio 4.30, 95% CI 2.30–8.02). In conclusion, the presence of malignant cells in peritoneal cytology is associated with decreased survival in early-stage cervical cancer. The possible benefit of systemic chemotherapy in this subgroup merits further investigation.

show abstract

Analyses of the association between cervical cancer and osteoporosis/osteoporotic fracture: a cross-sectional study using KoGES HEXA data

et al. 2021

View full text Add to dashboard Cite

Ovarian conservation for young women with clinical stage IB–IIB cervical cancer in Japan

Cited by 9 publications

References 10 publications

Identifying a candidate population for ovarian conservation in young women with clinical stage IB–IIB cervical cancer

Identifying a candidate population for ovarian conservation in young women with clinical stage IB–IIB cervical cancer

Significance of Malignant Peritoneal Cytology on the Survival of Women with Early-Stage Cervical Cancer: A Japanese Gynecologic Oncology Group Study

Analyses of the association between cervical cancer and osteoporosis/osteoporotic fracture: a cross-sectional study using KoGES HEXA data

Contact Info

Product

Resources

About