Ovarian carcinomas: at least five different diseases with distinct histological features and molecular genetics

Prat, Jaime; D’Angelo, Emanuela; Espinosa, Íñigo

doi:10.1016/j.humpath.2018.06.018

Cited by 194 publications

(225 citation statements)

References 121 publications

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“…The protocol for sectioning and extensively examining the fimbriated end (SEE‐FIM protocol) (Fig. ) was developed for processing risk‐reducing salpingo‐oophorectomy specimens . The entire tube is initially fixed for at least 4 hours to prevent denuding of the mucosal epithelial cells.…”

Section: Fallopian Tubementioning

confidence: 99%

“…Approximately 80% of ovarian tumors are benign. Almost 90% of malignant and borderline tumors are diagnosed after the age of 40 years …”

Section: Ovarymentioning

confidence: 99%

“…Common epithelial tumors account for about 90% of ovarian malignancies, high‐grade serous adenocarcinoma being the most common (70%). Some cases of high‐grade serous carcinomas may arise in the fallopian tubes …”

Section: Ovarymentioning

confidence: 99%

“…Recently, it has been hypothesized that cytokeratin7‐positive embryonic/stem cells would give rise to immunophenotypically distinct neoplastic progeny, which would support the old concept of “mullerian neometaplasia.” Besides the mesothelial origin, there is now compelling evidence that a number of what have been thought to be primary ovarian cancers actually originate in other pelvic organs and involve the ovary secondarily. In fact, it has been shown that some high‐grade serous carcinomas arise from precursor epithelial lesions in the distal fimbriated end of the fallopian tube, whereas endometrioid and clear cell carcinomas originate from ovarian endometriosis …”

Section: Ovarymentioning

confidence: 99%

“…Interestingly, carcinomas arising in patients with germline BRCA1 or BRCA2 mutations (hereditary ovarian cancers) are almost invariably the high‐grade serous type and commonly have TP53 mutations. An undetermined number of BRCA1‐ or BRCA2‐ related tumors arise from the epithelium of the fimbriated end of the fallopian tube, suggesting that at least some sporadic high‐grade ovarian and “primary” peritoneal serous carcinomas may actually develop from the distal fallopian tube and “spill over” onto the adjacent tissues (Table ) …”

Section: Ovarymentioning

confidence: 99%

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Pathology of cancers of the female genital tract including molecular pathology

Prat

Mutch

2018

Intl J Gynecology & Obste

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To better understand pathology reports, gynecologic oncologists must be familiar with the terminology used in gynecologic pathology. This chapter of the FIGO Cancer Report 2018 summarizes the clinical and pathological features of the most common cancers of the female genital tract, as well as their main molecular genetic alterations. In selected cases, an approach for processing surgical specimens is also included.

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Section: Fallopian Tubementioning

confidence: 99%

“…Approximately 80% of ovarian tumors are benign. Almost 90% of malignant and borderline tumors are diagnosed after the age of 40 years …”

Section: Ovarymentioning

confidence: 99%

Section: Ovarymentioning

confidence: 99%

Section: Ovarymentioning

confidence: 99%

Section: Ovarymentioning

confidence: 99%

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Pathology of cancers of the female genital tract including molecular pathology

Prat

Mutch

2018

Intl J Gynecology & Obste

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Angiogenesis inhibitors for the treatment of epithelial ovarian cancer

Gaitskell

Rogozińska

Platt

et al. 2023

Cochrane Database of Systematic Reviews

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Cytological features of ovarian or tubal high‐grade serous carcinoma: A retrospective study of 12 cases with abnormal cervical liquid‐based smear

Liu

Zhang

et al. 2021

Diagnostic Cytopathology

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Background: High-grade serous carcinoma (HGSC) is the most common epithelial carcinoma of the tubo-ovarian region, with a poor prognosis, which presents with an advanced stage at the time of diagnosis. This study summarizes the cytological features of cervical liquid-based cytological examination in order to diagnose ovarian or tubal HGSC at an early stage by cervical cytology smear.Methods: A total of 12 patients who were diagnosed with atypical glandular cell (AGC) and above lesions by cervical cytological examination and ovarian or tubal HGSC by histopathology were enrolled in this study. The cytological characteristics, including the arrangement and shape of the neoplastic cells, nuclear and cytoplasmic features, and the presence of tumor diathesis were reviewed.Results: Nine cases were determined to be AGC, and three cases were determined to be AGC favor neoplastic (AGC-FN) in the 12 cervical cytological diagnoses. The glandular cells showed significant atypia and proliferated actively with a threedimensional structure. Increased nuclear-to-cytoplasmic ratios, prominent nucleoli, and hyperchromasia were common. Vacuole-like changes were observed in the cytoplasm. Tumor diathesis was observed in only one case (1/12, 8.30%). Conclusion:Ovarian or tubal HGSC can occasionally be detected using cervical liquid-based cytology. It has distinct cytological characteristics. Primary ovarian or tubal HGSC with positive cervical cytology was accompanied by tumor cells in ascites, which suggested that the patient had progressed to an advanced stage.

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Ovarian carcinomas: at least five different diseases with distinct histological features and molecular genetics

Cited by 194 publications

References 121 publications

Pathology of cancers of the female genital tract including molecular pathology

Pathology of cancers of the female genital tract including molecular pathology

Angiogenesis inhibitors for the treatment of epithelial ovarian cancer

Cytological features of ovarian or tubal high‐grade serous carcinoma: A retrospective study of 12 cases with abnormal cervical liquid‐based smear

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