Ovarian carcinoma associated with endometriosis

Boyraz, Gökhan; Selçuk, İlker; Yazıcıoğlu, Aslıhan; Tuncer, Z S

doi:10.1016/j.ejogrb.2013.06.001

Cited by 28 publications

(16 citation statements)

References 16 publications

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“…Some studies have shown better survival in patients with EAOC (Erzen et al , 2001; Melin et al , 2011), whereas it was not different between the two groups in other studies (McMeekin et al , 1995; Komiyama et al , 1999; Orezzoli et al , 2008; Kumar et al , 2011; Cuff and Longacre, 2012; Katagiri et al , 2012). For explaining better prognosis in patients with EAOC, some investigators have reported that they may have favourable characteristics such as young age, early-stage disease, a specific histology such as endometrioid or clear cell carcinoma, low-grade disease and an increase of probability of optimal debulking surgery (McMeekin et al , 1995; Ziogas et al , 2000; Erzen et al , 2001; Orezzoli et al , 2008; Rossing et al , 2008; Kumar et al , 2011; Wang et al , 2013), whereas these findings were not identified in other relevant studies (Komiyama et al , 1999; Lim et al , 2009; Boyraz et al , 2013). …”

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confidence: 98%

Risk and prognosis of ovarian cancer in women with endometriosis: a meta-analysis

et al. 2014

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Background:The risk and prognosis of ovarian cancer have not been well established in women with endometriosis. Thus, we investigated the impact of endometriosis on the risk and prognosis for ovarian cancer, and evaluated clinicopathologic characteristics of endometriosis-associated ovarian cancer (EAOC) in comparison with non-EAOC.Methods:After we searched an electronic search to identify relevant studies published online between January 1990 and December 2012, we found 20 case–control and 15 cohort studies including 444 255 patients from 1 625 potentially relevant studies. In the meta-analysis, ovarian cancer risk by endometriosis and clinicopathologic characteristics were evaluated using risk ratio (RR) or standard incidence ratio (SIR), and prognosis was investigated using hazard ratio (HR) with 95% confidence interval (CI). Heterogeneity was evaluated using Higgins I2 to select fixed-effect (I2 ⩽50%) or random effects models (I2>50%), and found no publication bias using funnel plots with Egger's test (P>0.05). Furthermore, we performed subgroup analyses based on study design, assessment of endometriosis, histology, disease status, quality of study and adjustment for potential confounding factors to minimise bias.Results:Endometriosis increased ovarian cancer risk in case–control or two-arm cohort studies (RR, 1.265; 95% CI, 1.214–1.318) and single-arm cohort studies (SIR, 1.797; 95% CI, 1.276–2.531), which were similar in subgroup analyses. Although progression-free survival was not different between EAOC and non-EAOC (HR, 1.023; 95% CI, 0.712–1.470), EAOC was associated with better overall survival than non-EAOC in crude analyses (HR, 0.778; 95% CI, 0.655–0.925). However, progression-free survival and overall survival were not different between the two groups in subgroup analyses. Stage I–II disease, grade 1 disease and nulliparity were more common in EAOC (RRs, 1.959, 1.319 and 1.327; 95% CIs, 1.367–2.807, 1.149–1.514 and 1.245–1.415), whereas probability of optimal debulking surgery was not different between the two groups (RR, 1.403; 95% CI, 0.915–2.152). Furthermore, endometrioid and clear cell carcinomas were more common in EAOC (RRs, 1.759 and 2.606; 95% CIs, 1.551–1.995 and 2.225–3.053), whereas serous carcinoma was less frequent in EAOC than in non-EAOC (RR, 0.733; 95% CI, 0.617–0.871), and there was no difference in the risk of mucinous carcinoma between the two groups (RR, 0.805; 95% CI, 0.584–1.109). These clinicopathologic characteristics were also similar in subgroup analyses.Conclusions:Endometriosis is strongly associated with the increased risk of ovarian cancer, and EAOC shows favourable characteristics including early-stage disease, low-grade disease and a specific histology such as endometrioid or clear cell carcinoma. However, endometriosis may not affect disease progression after the onset of ovarian cancer.

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confidence: 98%

Risk and prognosis of ovarian cancer in women with endometriosis: a meta-analysis

et al. 2014

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“…A transition point from an endometriotic lesion (atypical endometriosis) to a frankly ovarian invasive carcinoma has been demonstrated in 36% to 42% of cases (19)(20)(21)(22)(23)(24). In the remaining cases, the tumor simply coexists with endometriosis without a transition point.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Endometriosis and Surface Epithelial Ovarian Tumors: A Review of Pathological Data

et al. 2018

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Background: Endometriosis is a prevalent benign condition arising from female reproductive system and affects about 7% to 10% of females. The association of this disorder with epithelial ovarian tumors has been a matter of interest in gynecology. Objectives: The present study was conducted to assess the association between endometriosis and different types of surface epithelial ovarian tumor. Methods: Microscopic slides of 182 cases with the diagnosis of surface epithelial ovarian carcinoma and borderline tumor from 2007 to 2014 were reviewed for the presence of endometriosis in a tertiary gynecological center. Additional data included age, tumor size and laterality, site of endometriosis, presence of atypical endometriosis, and concomitant uterine endometrial carcinoma. Results: Endometriosis was found in 32 out of the 182 (17.58%) of reviewed ovarian epithelial tumor cases. They included endometrioid carcinoma (46.87%), clear cell carcinoma (18.75%), borderline epithelial tumor (31.25%), and low-grade serous papillary carcinoma (3.12%). Conclusions: Endometrioid and clear cell types of ovarian tumors were most frequently associated with endometriosis.

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“…In previous studies, endometriosis-associated EOC cases were typically associated with earlystage, low-grade disease that may be related to better survival results [2,[10][11][12][13]. However, the association with endometriosis remains controversial as an independent prognostic factor after calibrating related clinical situations.…”

Section: Discussionmentioning

confidence: 99%

Clinical Outcomes of Patients with Clear Cell and Endometrioid Ovarian Cancer Arising in Endometriosis

Paik

Choi

Kim

et al. 2017

Journal of Minimally Invasive Gynecology

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Ovarian carcinoma associated with endometriosis

Cited by 28 publications

References 16 publications

Risk and prognosis of ovarian cancer in women with endometriosis: a meta-analysis

Risk and prognosis of ovarian cancer in women with endometriosis: a meta-analysis

The Association Between Endometriosis and Surface Epithelial Ovarian Tumors: A Review of Pathological Data

Clinical Outcomes of Patients with Clear Cell and Endometrioid Ovarian Cancer Arising in Endometriosis

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